Effects of demethylchlortetracycline on cellular action of antidiuretic hormone in vitro. Demethylchlortetracycline (DMC) can induce a syndrome of nephrogenic diabetes insipidus in man without affecting other renal functions. Because this pathologic change might be due to interference with the c...

6-Demethyltetracycline, when heated with nitric acid, forms a stable colored derivative having an absorption maximum at 425 mμ. 6-Demethylchlortetracycline under the same condition is unstable. When 6-demethylchlortetracycline is heated with nitric acid, the color produced by the 6-demethyltetr...

The ultrafiltration of fermentation broths of demethylchlortetracycline (DMCT) produced at an industrial scale at CIPAN SA, has been carried out, using two ultrafiltration systems of different module geometries: a tubular module (B1 from Paterson Candy International Ltd.) and a plate-and-frame m...

A series of [4-(aryloxy)phenyl]cyclopropyl methanones were synthesized by reaction of different benzyl alcohols with 4-chloro-4′-fluorobutyrophenone in DMF in the presence of NaH/TBAB. The methanones were further reduced to respective methanols. The antitubercular activity of these compounds wa...

The pharmacological properties of T-2328 were evaluated as an antagonist of the tachykinin neurokinin 1 (NK1) receptor. T-2328 inhibited the specific binding of [3H][Sar9,Met(O2)11]substance P to tachykinin NK1receptors in human lymphoblastic IM9 cells with Kiof 0.08 nM. In the same assay, Kifor...

The present work uses DFT calculations to characterize the conformational and hydrogen-bonding properties of O6-[4-oxo-4-(3-pyridyl)butyl]guanine (POB-G), a DNA adduct caused by tobacco. POB-G is found to adopt many isoenergetic conformations that allow for discrete interactions between the bulk...

BackgroundAccording to the European Drug Report, the use of novel psychoactive substances (NPS) is constantly growing. NPS are widely abused by human adolescent subjects. 5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is one of the most frequently used hallucinogenic NPS. 5-MeO-DIPT intoxicati...

ABSTRACTThe coupled reaction of methyl acetate and n-hexane was carried out over a HZSM-5 catalyst. In addition to a thermal coupling effect, systematic variations in the product distribution were also observed in the coupled system. The bezene-toluene-xylene (BTX) selectivity was remarkably imp...

A systematic study on sulfonamide derivatives with salicylamide core is presented for possible use in pharmaceutical applications. The molecular structure of eight different compounds has been investigated by FTIR in the frequency range 4000–400 cm−1 to recognize the possible geometrical shape ...

H-ZSM-5 and Cu-HZSM-5 composite zeolites with a medium SiO2/AL2O3 ratio was successfully synthesized using a incipient-wetness impregnation method and characterized via physico-chemical analysis, such as X-ray diffraction (XRD), scanning electron microscope (SEM),N2-physisorption, BET, and tempe...

Porous carbons with high adsorption capacity of n-hexane were developed by carbonization of MOF-5 with green carbon sources (glucose or sucrose) and activation with KOH. The effects of the additions of carbon sources and KOH activator on the porosity of porous carbon were discussed. The porous c...

The kinetics of n-butane conversion over HZSM-5 zeolites at low temperature were studied. The results show that n-butane conversion mainly occurs via monomolecular pathway under low n-butane pressure (

The objective of this work is to investigate the catalytic effect of a series of modified HZSM-5 zeolites on n-decane cracking at 500 °C and atmospheric pressure. The zeolite catalysts were prepared with phosphorus and/or mesopore modification by excessive impregnation and/or hydrothermal treat...

Green synthesis of nanosized AlPO-n and SAPO-n (n = 5 and 18) crystals with AFI- and AEI-type structures from non-reacted precursor suspensions with an essential chemical compensation is presented. The crystallization of both materials was accomplished within few minutes (5–18 min) instead of s...

Interaction between azelnidipine and bovine serum albumin (BSA) was investigated by fluorescence spectroscopy and circular dichroism (CD). Azelnidipine effectively quenched the intrinsic fluorescence of BSA via a combination of static and dynamic quenching, forming azelnidipine–BSA complex with...

A sensitive and simple method was developed for determination of the enantiomers of azelnidipine, (R)-(−)-azelnidipine and (S)-(+)-azelnidipine, in human plasma using chiral liquid chromatography with positive ion atmospheric pressure chemical ionization tandem mass spectrometry. Plasma samples ...

Azelnidipine and amlodipine are dihydropyridine-type Ca2+ channel blockers for the treatment of hypertension. Although these drugs have high vasoselectivity and small negative inotropic effects in vivo, little is known regarding their direct effects on cellular contractility without humoral regu...

AimsTo assess the acute effects of intravenous azelnidipine, a third-generation L-type calcium channel blocker, on sympathetic outflow from the central nervous system and to compare the effects of intravenous azelnidipine with those of intravenous nifedipine.

The aim of the present study was to compare the effects of olmesartan combined with azelnidipine versus olmesartan combined with trichlormethiazide, on home blood pressure (BP) and pressure variability in type II diabetes mellitus patients using home BP telemonitoring system. We performed an ope...

In present study, based on the two polymorphs (α and β form) of azelnidipine (AZE), 12 complexes of AZE and oxalic acid (OXA) were prepared by solvent-assisted grinding (SG) and neat powder grinding (NG) methods at the AZE/OXA molar ratios of 2:1, 1:1, and 1:2. The effect of the different poly...