Polarized far i.r. spectra of potassium hydrogen maleate monocrystals recorded at 295 and 10 K are reported and tentative assignments of bands are given.

The polarized infrared spectra of single crystals for potassium hydrogen maleate (KHM) and its deuterated analogue (KDM) have been measured at room and low (approximately 15 K) temperature. The hydrogen bond and internal vibrations of the maleate ion are discussed. The antisymmetric stretching v...

The aim of this study was to develop a new gastro-retentive formulation that has the capability to maintain the release of rosiglitazone in the gastric medium. For this purpose, we have used formulation by design approach and predicted the formulation characteristics of the final formulation by ...

The use of gelatin has been gaining recognition in ocular delivery for its safety profile and biocompatible properties. Timolol Maleate (TM) is an anti-glaucoma drug possessing poor corneal penetration while causing eye irritation making it an ideal candidate for novel nanoparticulate systems. T...

The pathway for the electrochemical formation of 2-benzhydrylidene-4,4-diphenyl-[1,3]oxathiolan-5-one (2), in dichloromethane tetraethylammonium bromide on graphite cathode is proposed. It involves reaction between electrogenerated diphenylketene (3), 2-bromo-2,2-diphenylacetyl bromide (1) and s...

Optimization of benzoic acid derivatives by introducing substituents into the diphenyl urea moiety led to the identification of compound 20l as a potent VLA-4 antagonist. Compound 20l inhibited eosinophil infiltration into bronchial alveolar lavage fluid in a murine asthma model by oral dosing a...

Searching for an effective and safer alternative to the citrus fruit preservative 2,4-dichlorophenoxyacetic acid (2,4-d) is an issue of common concern in citrus-producing countries. In this study, 27 structural and functional analogues of 2,4-d were preliminarily selected from ZINC database by c...

Three new silver complexes based on 2,6-dichlorophenylacetate (dcpa), namely [Ag2(dcpa)2]n (1), [Ag(NH3)2](dcpa) (2), and [Ag3(N,N-eten)(dcpa)3]2 (3) (N,N-eten = N,N-diethylethylenediamine), were synthesized and structurally characterized. The dcpa ligand adopts a µ2-η1:η1 bridging coordinati...

The diphthamide modification of translation elongation factor 2 is highly conserved in eukaryotes and archaebacteria. Nevertheless, cells lacking diphthamide can carry out protein synthesis and are viable. We have analyzed the phenotypes of diphthamide deficient cells and found that diphthamide ...

SummaryMammalian selenocysteine (Sec)-containing proteins, selenoproteins, are important to (patho)physiological processes, including redox homeostasis. Sec residues have been recalcitrant to mass spectrometry-based chemoproteomic methods that enrich for reactive cysteine (Cys) residues with ele...

A novel fluorescent probe O-hNRSel based on tetralin-xanthene fused dye O-hNR was designed and synthesized by introducing 2,4-dinitrobenzenesulfonate functionality. This probe is able to detect selenocysteine (Sec) with rapid response time (2 min) and a large fluorescence enhancement at 624 nm (...

BackgroundMethylation driven by thiopurine S-methylatransferase (TPMT) is crucial for deactivation of cytostatic and immunosuppressant thiopurines. Despite its remarkable integration into clinical practice, the endogenous function of TPMT is unknown.

ABSTRACTSelenium is included in selenoprotein sequences, which participate in enzymatic processes necessary to preserve optimal health. Some lactic acid bacteria carry out the biotransformation of inorganic selenium in their metabolism. The complete biochemical mechanism of selenium biotransform...

In this work, a novel enzyme-mimicking nanocomposite of Mn(II)-poly-L-histidine (PLH) functionalized carboxylated multi walled carbon nanotubes (CMWCNTs) was designed and synthesized. Based on the catalase-like activity of the nanocomposite, a non-enzymatic hydrogen peroxide (H2O2) biosensor was...

Organisms, in general, respond to environmental stress by altering their pattern of protein expression (proteome), as an alternative to growing in stressful conditions. A strain of Meyerozyma guilliermondii resistant to manganese was isolated from a sample of water collected from mine drainage i...

A natural clinoptilolite zeolite (Z–N) and its hybrid form (Z–Mn) prepared by impregnation with hydrated manganese oxide have been evaluated for the simultaneous removal of ammonium and phosphate. The ammonium sorption capacity reported by Z–Mn was 23 ± 2 mg N–NH4+/g; while the phosphate up...

Amorphous biodegradable metal phosphate nanomaterials are considered to possess great potential in cancer theranostic application due to their promise in providing ultra-sensitive pH-responsive therapeutic benefits and diagnostic functions simultaneously. Here we report the synthesis of photosen...

A Fe–Mn oxide adsorbent (FMO) with the Fe/Mn molar ratio of 5:1 was combined to remove phosphate in aqueous solution. An apparently irregular surface and heterogeneous porous structure were found in the SEM images of FMO. XPS spectra showed that manganese and iron existed mainly in the +IV and ...

Mn(III) has great potential for the oxidation of organic pollutants. In permanganate/bisulfite system, Mn(III) would form and react with target organics within seconds. Fast reaction makes revealing the reaction mechanisms difficult. In comparison, Fe2+/Mn2+/sulfite system can slowly release Mn(...

Environmental pollution by industrial effluents polluted with hazardous heavy metals has great concern. A novel microemulsion system (sodium dodecanoate/pentan-1-ol/heptane/NaCl) was prepared for the treatment of cobalt (Co) and manganese (Mn) wastewater. The effects of the batch extraction cond...