The linear viscoelastic behavior of molten hybrid nanocomposites poly [(propylmethacryl-heptaisobutyl-POSS)-co-methyl methacrylate], denoted POSSn-MMA, was investigated; POSS content varied up to n = 45 wt%. The nanocomposites were amorphous and ΔTg ≈ −20 K. The melts exhibited linear viscoela...

Novel polymers containing polyhedral oligomeric silsesquioxane (POSS) pendant groups have been synthesized and evaluated as components of resist formulations. Random copolymers of polymerizable ethyl-POSS containing monomers with various acrylate type monomers including tert-butyl methacrylate a...

An extensive number of aliphatic diphenyl esters, C6H5OOC(CH2)nCOOC6H5 (n=0,...,8,10,11,12,14), have been prepared in pure form. The crystalline melting points of these esters exhibit an odd-even temperature behaviour, with the higher-melting even series (n even) displaying a minimum for n = 8 w...

With the aim of discovering a novel class of non-phosphorus-based fructose-1,6-bisphosphatase (FBPase) inhibitors, a series of 2,5-diphenyl-1,3,4-oxadiazoles were synthesized based on the hit compound (1) resulting from a high-throughput screening (HTS). Structure–activity relationship (SAR) st...

Density Functional Theory methods (BLYP, B3PW91, and B3LYP) with the 6-311G (d,p) basis set were used to calculate the molecular structure, vibrational frequencies and infrared intensities of the title compound. A comparison between the calculated geometric parameters and the corresponding singl...

The reference standard N-(3-(4-methylpiperazin-1-yl)−1-(5-methylpyridin-2-yl)−1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide (9) and its demethylated precursor N-(1-(5-methylpyridin-2-yl)−3-(piperazin-1-yl)−1H-pyrazol-5-yl)pyrazolo[1,5-α]pyrimidine-3-carboxamide (8) were synthesized fr...

To study the effect of mineral supplementation on 2,3-DHP toxicity, 16 mature Angora wethers were randomly allocated to four treatment groups (M, DM, D and C). Two hours after the morning feeding; group M received a mineral mixture of 2 g of Fe2(SO4)3 · 7H20, 2 g of MgSO4 · 7H20 and 2 g of ZnS...

SummaryA Gram-positive sporeforming bacterium isolated from the rumen of sheep in Venezuela is described. The isolated strain (162) degraded the toxic amino acid mimosine, a component of the forage legume Leucaena. Strain 162 also degraded two products of mimosine metabolism, 3(hydroxy)-4-(1H)-p...

Despite its structural similarity to catechol, 2,3-dihydroxypyridine is not a substrate but a “dead-end” inhibitor of purified pig liver catechol-O-methyltransferase. It inhibits the methylation of 3,4-dihydroxyphenylacetic acid competitively with an inhibitor constant of 15 μM. Against the m...

A polyurethane-containing pyridinium moiety was prepared by chain extension of the isocyanate terminated prepolymer based on poly(tetramethylene oxide) glycol and tolylene diisocyanate with 2,3-dihydroxypyridine. This was converted into zwitterionomer by the reaction with 1,3-propane sultone. Th...

The kinetics of the Rose Bengal (RB)-sensitized photooxidation of 2,3-dihydroxypyridine (2,3-DHP) and 2,4-dihydroxypyridine (2,4-DHP), two compounds profusely employed in multiple fields such as pesticides design, pharmacology, and clinical therapeutics have been studied in water at pH 5, 11 and...

Two new one-dimensional oxalato-bridged copper(II) compounds of formula [Cu(ox)L2]n (1) and {[Cu2(ox)2L′3]·L′}n (2) [ox=oxalate dianion, L=3-hydroxypyridine (pyOH) and L′=2-amino-4-methylpyridine (ampy)] have been synthesized and characterized by FT-IR spectroscopy, variable-temperature magn...

The oxidative polycondensation reaction conditions of 2-amino-3-hydroxypyridine (AHP) and 2-[benzilydeneimino] pyridine-3-ol (BIP) were studied by oxidants such as with air O2, NaOCl and H2O2. Oligo-2-amino-3-hydroxypyridine (OAHP) was synthesized from the oxidative polycondensation of AHP with ...

The popularity of hair dyes use has been increasing regularly throughout the world as per the demand of hair coloring fashion trends and other cosmetic products. 2-Amino-3-hydroxypyridine (A132) is widely used as a hair dye ingredient around the world. We are reporting first time the phototoxici...

The synthesis of N-benzyl-2-chloroindole-3-carboxylic acids related to indomethacin is reported. These compounds were tested on in vitro human neutrophil activation. Some of them, more soluble in water, were tested to define the influence on prostaglandin biosynthesis via inhibition of cyclooxyg...

Reaction of 2-chloroindole-3-carbaldehyde with epibromohydrin gives the expected 1-(oxiran-2-ylmethyl) derivative. However the analogous reaction with epichlorohydrin leads to the formation of the oxazolo[3,2-a]indole skeleton. Some chemical properties of this tricyclic system were investigated....

One of the hallmarks of Alzheimer's disease (AD) in the brain are amyloid-β (Aβ) plaques, and metal ions such as copper(II) and zinc(II) have been shown to play a role in the aggregation and toxicity of the Aβ peptide, the major constituent of these extracellular aggregates. Metal bindin...

Two new organic compounds composed of 8-hydroxyquinoline and benzimidazol-2-one units have been successfully prepared, and identified by different spectroscopic methods (IR, NMR and Elemental analysis). The synthesized heterocyclic namely 1-((8-hydroxyquinolin-5-yl)methyl)-3-(prop‑1-en-2-yl)-1H-...

Two newly substituted 8-Hydroxyquinoline derivatives, namely 5-((2-(4-bromophenyl)-5, 6-dimethyl-1H-benzimidazol-1-yl) methyl) quinolin-8-ol (BQM) and 5-((2-(4-bromophenyl)-1H-benzimidazol-1-yl) methyl) quinolin-8-ol (BQ) were synthesized and identified by elemental analysis, IR, 1H NMR and 13C ...

In the present investigation, three 5-amino-8-hydroxyquinolines derivatives namely, 5-aminomethyl-8-hydroxyquinoline (AMHQ), 5-N-acethylaminomethyl-8-hydroxyquinoline (ACAMHQ), 5-N,N′-dimethylaminomethyl-8-hydroxyquinoline (DMHQ) were prepared and characterized by IR, 1H NMR, 13C NMR, Elemental...