The reaction of bis(lithiomethyl)dimethylsilane with dimethyldichlorosilane in diethyl ether has served in the preparation of 1,1,3,3-tetramethyl-1,3-disilacyclobutane in 24% yield and 1,1,3,3-tetramethyl-1-sila-3-germacyclobutane has been prepared in 21% yield by the Barbier reaction between bi...

The molecular structures of 1,1-dimethylsilacyclobutane (DMSICB) and 1,1,3,3-tetramethyl-1,3-disilacyclobutane (TMDSICB) have been studied by gas-phase electron diffraction at room temperature. Both molecules exist in a puckered conformation. The major geometrical parameters obtained are as foll...

Gas electron diffraction data are applied to determine the geometrical parameters of the 1,1,3,3-tetramethyl-1,3-disilacyclobutane molecule using a dynamic model where the ring puckering was treated as a large amplitude motion. The structural parameters and parameters of the potential function w...

Several homogeneous and heterogeneous catalysts have been used for the metathesis of functionalized olefins. The homogeneous catalyst WCl6- (or WOCl4-) 1,1,3,3-tetramethyl-1,3-disilacyclobutane allows the metathesis of various functionalized olefins with short chain length (esters of fatty acids...

Telomerization of 1,1,3,3-tetramethyl-1,3-disilacyclobutane with hydrosilanes is facilitated by UV irradiation in the presence of Pt(acac)2. When olefin is also present, photoactivated hydrosilylation competes with telomerization. The dependence of product distribution on the reactivity of the h...

The gas-phase chemical species produced from both the direct decomposition of 1,1,3,3-tetramethyl-1,3-disilacyclobutane (TMDSCB) on a tungsten filament and the secondary reactions in the HWCVD reactor were identified by vacuum ultraviolet laser single-photon ionization coupled with time-of-fligh...

3-(Triethoxysilyl)propionitrile (TESPN) sol–gel has been prepared under different conditions. It was employed for coating the surfaces of quartz and aluminum. Infrared (IR) and Raman spectra of TESPN and TESPN sol–gels have been recorded in the study of the sol–gel process. Transmission and r...

The 5-HT1AR partial agonist PET radiotracer, [11C]CUMI-101, has advantages over an antagonist radiotracer as it binds preferentially to the high affinity state of the receptor and thereby provides more functionally meaningful information. The major drawback of C-11 tracers is the lack of cyclotr...

The present study investigated the passive transdermal delivery of 3-fluoroamphetamine hydrochloride (PAL-353) and evaluated the effects of chemical and physical enhancement techniques on its permeation through human skin. In vitro drug permeation studies through dermatomed human skin were perfo...

A novel series of substituted 1,2,3-benzotriazines and pyrido[3,2-d]-1,2,3-triazines were synthesized. The abilities of these compounds to inhibit the VEGFR-2 kinase activity and the proliferation of human microvascular endothelial cells (MVECs) were determined. 6-Methoxy-4-substituted-1,2,3-ben...

The electrochemical behaviour of triphenylgermanium bromide has been thoroughly investigated using various electrochemical techniques including polarography, cyclic voltammetry and controlled potential coulometry. It has been found that in non-aqueous solvents triphenylgermanium bromide gives on...

Condensation of d-fructose with pentane-2,4-dione in mildly alkaline aqueous solution generates a novel sugar-based scaffold: a 2-C-fructosyl-propanone compressed by formation of a cycloacetal into a 2,7-dioxabicyclo[3.2.1]octane framework.

The synthesis of new polyhydroxylated 8-oxabicyclo[3.2.1]octanes and 2,7-dioxatricyclo[4.2.1.03,8]nonanes is described. These structures is an interesting synthetic blocks for potential bioactive molecules. The precursor, 3-chloro-8-oxabicyclo[3.2.1]oct-6-ene-2,4-dione was obtained from reaction...

Carbon-13 NMR chemical shifts are reported for three series of Group IV aromatics p-XC6H4Y(CH3)3 where Y = C, Si and Ge. The shifts for the C(1), C(2), CH3 and C(α) carbons correlate with the substituent parameters σ, and σoR, and the slopes of the CH3 correlations suggest roughly equal trans...

The reaction of Me3GeC6H5 and Me3GeC6H4Me with Me2CH+, Me3C+, and Me2Cl+ has been studied in the gas phase at pressures spanning from 1 Torr (chemical ionization mass spectrometry) to 1 atm (radiolytic technique). The reactions conform to the general model of electrophilic aromatic substitution ...

The oxidation of 2,6-di-tert-butylphenol (DTBP) with tert-butylhydroperoxide (ButOOH) catalyzed by cobalt(II) phthalocyanine tetrasulfonate ([CoPcTS]4−) in a 4:1 methanol–water mixture gave predominantly the coupled products 3,3′,5,5′-tetra-tert-butyl-4,4′-diphenoquinone (DPQ) and 4,4′-dihy...

The standard massic energies of compounds of 4-tert-butylbiphenyl and 4,4′-di-tert-butylbiphenyl were measured at T = 298.15 K by static-bomb combustion calorimetry. The standard enthalpies of vaporization, fusion and sublimation were measured in a Calvet microcalorimeter, or by differential sc...

The diiron bisakyl complex of 9,10-ethanoanthracene-trans- 11,12-dicarboxyIic acid was obtained from the corresponding acid dichloride and Na[Fe(CO)2Cp]. Its crystal structure was determined. Photo- and thermolysis reactions were studied, giving not the expected bisalkyl complexes but eliminatio...

The fungus Nodulisporium sp. (No. 65-12-7-1), which can produce a rare class of steroids (4-methyl-progesteroids) in rice solid medium, was subjected to a one strain-many compounds (OSMAC) approach. It was found to produce ten new 4-methyl-progesteroid derivatives named nodulisporisteroids C–L ...

The conversion of pregna-4,9(11)-diene-17α,21-diol-3,20-dione 21-acetate (I) and 17,21-diacetate (VI) by Nocardioides simplex VKM Ac-2033D was studied. The major metabolites formed from I were identified as pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate (II) and pregna-1,4,9(11)-tri...