It is over 30 years since the regulatory peptide galanin was discovered by Professor Mutt and co-workers. Galanin exerts its effects by binding to three galanin G-protein coupled receptors, namely GAL1R, GAL2R and GAL3R. Each galanin receptor has a different distribution in the central nervous s...

It has been demonstrated previously that central administration of the N-terminal galanin fragment (1–15) elicits hypertension and tachycardia and antagonizes the hypotensive effect of the parent molecule galanin-(1–29). In order to further clarify the role of galanin in central cardiovascular...

The efferent pathways involved in the tachycardia induced by intracisternal injections of the N-terminal galanin fragment (1–15) (GAL (1–15)) and galanin (GAL (1–29)) has been evaluated in rats pretreated with the cholinergic antagonist atropine or the β-antagonist propranolol. The pretreatm...

The title compound (S)-α-methylserinal acetonide has been efficiently prepared from (S)-α-methylserine, which is readily available in enantiomerically pure form by Curtius rearrangement of α,α-dialkyl 2-cyanoesters obtained by diastereoselective alkylation of (1S,2R,4R)-10-dicyclohexylsulfam...

A novel efficient synthetic approach to 4-amino-2-trifluormethyl quinoline derivatives is described via palladium-catalyzed cascade reactions of isocyanides with readily available N-(ortho-iodo)aryl enamines under mild conditions. The target heterocycles can be found in many natural products or ...

4-Amino-N-adamantylphthalimide (1) is a dye with moderate absorptivity (in CH3CN ε363 = 4200 M−1 cm−1) and high quantum yield of fluorescence (ΦF = 0.15–0.80) that exhibits fluorosolvatochromic properties. The dye can be excited at 405 nm and the position of fluorescence maximum and the Stoke...

Novel series of amphiphilic monoazo dyes were synthesized using 4-amino-N-decyl-1, 8-naphthalimide by coupling with different substituted anilines and naphthalenes in appropriate reaction condition. The intermediates and the dyes were purified by recrystallization methods. The structures of the ...

Copolymers containing 2-(N,N-diethylamino)ethyl methacrylate (DEAEMA) and poly(ethylene glycol) methyl ether methacrylate with Mn = 500 g mol−1 (PEGMA500) are one of the most promising combinations of smart polymers with biocompatibility character for uses in medical applications. The homo and t...

Catalyst-free one-pot CN and CC bond formation is described as a simple and ecofriendly method for the synthesis of pyrazole-aniline linked coumarin derivatives. Employing this protocol, a series of derivatives were synthesized in good to excellent yields and tested against different bacterial s...

Aim of the study was to evaluate the effect of quercetin and enrofloxacin with/without quercetin on elimination of pathogen Escherichia coli O78/H12 in infected chickens. Effect of quercetin on disposition of enrofloxacin was investigated and Pharmacokinetic-pharmacodynamic indices were calculat...

Veterinary antibiotics are available for uptake by the plants through sources such as manure, irrigation, and atmospheric interaction. The present study was conducted to estimate the half-lives of three veterinary antibiotics, chlortetracycline (CTC), enrofloxacin (ENR), and sulphathiazole (STZ)...

The use of chitosan microparticles as chromatographic support has received much attention. In this study, the effects of process parameters, namely, chitosan molecular weight, chitosan concentration, molar ratio of amino group to aldehyde group, volume ratio of water to oil phase and stirring sp...

Specific ssDNA aptamers for the antibiotic enrofloxacin (ENR) were isolated from an enriched nucleotide library by SELEX (Systematic Evolution of Ligands by EXponential enrichment) method with high binding affinity. After seven rounds, five aptamers were selected and identified. Apt58 with highe...

Current treatment options for snake infections are straightforward for experienced veterinarians, but are less so for non-veterinarian snake owners. In this study, we analysed the in-vitro permeation of an antibiotic, enrofloxacin, administered percutaneously to the shed skin of a snake (Python ...

Two approaches to set up a functional protein chip platform for the detection of enrofloxacin in milk have been carried out: (A) the functionalization of enrofloxacin with either large carrier proteins (BSA, ALP, KLH, HRP) or bifunctional crosslinkers (adipic acid dihydrazide) and subsequent imm...

Enrofloxacin (ENR) is the most commonly used antibiotic in crustacean farming in China. Diet supplementation with lactic acid (LA) may, however, affect the efficacy and safety of ENR-based drugs. The aims of this study were to investigate the effects of LA on drug residues and elimination of ora...

In this study, the blood concentrations of enrofloxacin administered transdermally to 3 different reptilian species, Python regius, Acrantophis dumerili, and Boa constrictor imperator, at 50 mg/kg was determined. The formulation used was a transdermal commercial vehicle, Pentravan cream, a hydro...

Enrofloxacin (ENR) is one of the environmental pollutants need to remove in many wastewater treatment processes. Traditional methods for measuring ENR are often complex and time-consuming. Due to their low cost and high efficiency, fluorescent carbon dots can be used for detecting many pharmaceu...

Magnetic imprinted TiO2 photocatalyst (MITP) with excellent transparency was prepared via a microwave heating method based on enrofloxacin hydrochloride (ENRH) as the template molecule, methyl methacrylate (MMA) as the functional monomer, and TiO2@SiO2@Fe3O4 (TSF) as the matrix material. TSF was...

The n-butyl quaternary salt of the 5-HT4 receptor agonist and 5-HT3 receptor antagonist, renzapride, is reported to be a potent and selected 5-HT4 receptor agonist.