good price,good quality,good service Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaos
ISO Factory/Good qualityAppearance:off white Storage:dry and cool place Package:10G/BAG; 1KG/BAG ;25KG/DRUM Application:Active pharaceutical ingredients Transportation:BY SEA,AIR,EXPRESS Port:shenzhen/shanghai
DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:90357-06-5
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryWe are very compeitive on Bicalutamide.Our mfr with DMF document. Product Name: Bicalutamide CAS: 90357-06-5 MF: C18H14F4N2O4S MW: 430.37 EINECS: 200-001-8 Product Categories:
Cas:90357-06-5
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:90357-06-5
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inquiryBicalutamide 1.CAS RN: 90357-06-5 2.English Name:Bicalutimide Chemical name: N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxyl-2- methylpropanemide Synonyms: Bicalutamide (Subject to
Cas:90357-06-5
Min.Order:1 Kilogram
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Type:Other
inquiryUnique advantages of Bicalutamide Cas 90357-06-5 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white powder Storage:cool dry place Package:1kg/foil bag;25kg
Cas:90357-06-5
Min.Order:1 Kilogram
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Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:90357-06-5
Min.Order:1 Gram
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inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:90357-06-5
Min.Order:1 Kilogram
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Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Bicalutamide CAS NO:90357-06-5 Grade:Medical scientific research and export Molecular formula:C18H14F4N2O4S Molecular weight:430.37 Product Quality 12 years of chemical raw materials Mature operation of the industry System stabi
Cas:90357-06-5
Min.Order:25 Kilogram
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inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Cas:90357-06-5
Min.Order:1 Kilogram
FOB Price: $0.9 / 1.0
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Type:Trading Company
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Min.Order:1 Kilogram
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Type:Trading Company
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Type:Trading Company
inquiryItems Result Appearance Powder Content 99.0%min Moisture <0.04% Brand
Appearance:White to off-white powder Storage:R.T Package:25kg/Barrel Application:Antiandrogens Transportation:Express/Sea/Air Port:Any port in China
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Min.Order:1 Kilogram
FOB Price: $489.0 / 665.0
Type:Lab/Research institutions
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Cas:90357-06-5
Min.Order:100 Gram
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Type:Other
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
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Min.Order:1 Kilogram
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inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:white powder Storage:storage in a dr
Cas:90357-06-5
Min.Order:100 Gram
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Type:Lab/Research institutions
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Min.Order:10 Gram
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Type:Trading Company
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Bicalutamide CAS:90357-06-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
Cas:90357-06-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
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Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
factory Bicalutamide 90357-06-5 in China Bicalutamide Chemical Properties Melting point 191-193°C storage temp. Store at RT solubility
Cas:90357-06-5
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:90357-06-5
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryN-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide
Bicalutamide
Conditions | Yield |
---|---|
Stage #1: N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide With potassium permanganate; tetra(n-butyl)ammonium hydrogensulfate In water; ethyl acetate at 25 - 30℃; for 2.5h; Stage #2: With sodium metabisulfite In water; ethyl acetate for 1h; | 100% |
With (dimethyl dioctadecylammonium)3[PW12O40]; dihydrogen peroxide In dichloromethane at 25℃; for 0.416667h; Catalytic behavior; Temperature; Reagent/catalyst; | 99.1% |
Stage #1: N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide With dihydrogen peroxide; sodium tungstate; methanesulfonic acid In water; ethyl acetate at 25 - 32℃; for 6h; Stage #2: With sodium thiosulfate In water; ethyl acetate for 0.5h; Product distribution / selectivity; | 98% |
4-Fluorothiophenol
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide
Bicalutamide
Conditions | Yield |
---|---|
Stage #1: 4-Fluorothiophenol; N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In water; ethyl acetate at 25 - 30℃; for 3h; Stage #2: With potassium permanganate In water; ethyl acetate for 2.5h; Stage #3: With sodium metabisulfite In water; ethyl acetate at 50℃; for 1h; Product distribution / selectivity; | 97.3% |
N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide
A
N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfinyl-2-hydroxy-2-methyl-propanamide
B
Bicalutamide
Conditions | Yield |
---|---|
With urea hydrogen peroxide adduct In tetrahydrofuran; formic acid; water at 27 - 35℃; for 1h; | A 0.08 %Chromat. B 96% |
1-(methylsufonyl)-4-fluorobenzene
N-(4-cyano-3-(trifluoromethyl)phenyl)-2-oxo propanamide
Bicalutamide
Conditions | Yield |
---|---|
Stage #1: 1-(methylsufonyl)-4-fluorobenzene With n-butyllithium In tetrahydrofuran at -78℃; for 0.333333h; Stage #2: N-(4-cyano-3-trifluoromethyl-phenyl)-2-oxo-propionamide In tetrahydrofuran at -78 - 20℃; Further stages.; | 95% |
Stage #1: 1-(methylsufonyl)-4-fluorobenzene With n-butyllithium In tetrahydrofuran for 1h; Stage #2: N-(4-cyano-3-trifluoromethyl-phenyl)-2-oxo-propionamide In tetrahydrofuran for 0.333333h; | 90% |
With n-butyllithium In tetrahydrofuran | 1.67 g (90%) |
3-chloro-benzenecarboperoxoic acid
N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide
Bicalutamide
Conditions | Yield |
---|---|
In dichloromethane | 94% |
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide
Bicalutamide
Conditions | Yield |
---|---|
With cesium fluoride In water at 90℃; for 15h; | 93% |
With cesium fluoride In water at 90℃; for 15h; Inert atmosphere; | 93% |
4-Fluorothiophenol
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide
Bicalutamide
Conditions | Yield |
---|---|
Stage #1: 4-Fluorothiophenol; N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide With oxygen In acetonitrile at 45℃; for 10h; Stage #2: With oxone In acetonitrile for 18h; Temperature; Reagent/catalyst; | 88% |
Stage #1: 4-Fluorothiophenol; N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide With oxygen In ethanol at 45℃; Green chemistry; Stage #2: With Oxone In ethanol at 45℃; Green chemistry; | 68% |
4-cyano-3-(trifluoromethyl)phenylisocyanide
1-(4-fluorophenylsulfonyl)propan-2-one
Bicalutamide
Conditions | Yield |
---|---|
Stage #1: 4-cyano-3-(trifluoromethyl)phenylisocyanide With titanium tetrachloride In dichloromethane for 1h; Passerini reaction; Cooling with ice; Stage #2: 1-(4-fluorophenylsulfonyl)propan-2-one In dichloromethane for 3h; Passerini reaction; Stage #3: With water In dichloromethane for 0.333333h; | 66% |
sodium 4-fluorobenzenesulfinate
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide
Bicalutamide
Conditions | Yield |
---|---|
With tetrabutylammomium bromide In chloroform; water for 96h; Heating / reflux; | 48% |
With sulfuric acid In ethanol for 6h; Heating / reflux; |
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-3-iodo-2-methylpropanamide
sodium 4-fluorobenzenesulfinate
Bicalutamide
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 60℃; for 8h; | 23% |
Bicalutamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 87 percent / tetrabutylammonium fluoride / dimethylsulfoxide / 0.5 h / 90 °C 2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C 2.2: 95 percent / tetrahydrofuran / -78 - 20 °C View Scheme |
(4-methanesulfonylphenyl)-N,N-dimethyl-amine
Bicalutamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 31 percent / CH2Cl2 / 20 h / Heating 2.1: 87 percent / tetrabutylammonium fluoride / dimethylsulfoxide / 0.5 h / 90 °C 3.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C 3.2: 95 percent / tetrahydrofuran / -78 - 20 °C View Scheme |
4-Fluorothiophenol
Bicalutamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydride / tetrahydrofuran / 2 h / 20 °C 2: 255.2 g / hydrogen peroxide; trifluoroacetic anhydride / CH2Cl2 / 16 h / 20 °C View Scheme |
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide
Bicalutamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 98.6 percent / hydrogen peroxide; trifluoroacetic anhydride / CH2Cl2 / 1.67 h / 20 °C 2: sodium hydride / tetrahydrofuran / 2 h / 20 °C 3: 255.2 g / hydrogen peroxide; trifluoroacetic anhydride / CH2Cl2 / 16 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: m-chloroperbenzoic acid, 2,6-di-tert-butyl-4-methylphenol / 1,1,1-trichloro-ethane / 6 h / Heating 2: 1.) NaH / 1.) THF, 0 deg C, 15 min, 2.) room temperature, 16 h 3: 90 percent / m-chloroperbenzoic acid / CH2Cl2 / 16 h / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 1.1: dihydrogen peroxide; trifluoroacetic anhydride / dichloromethane / 24 h / 20 °C / Inert atmosphere 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 - 20 °C / Inert atmosphere 2.2: 24 h / 20 °C / Inert atmosphere 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 25 °C / Inert atmosphere View Scheme |
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide
Bicalutamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydride / tetrahydrofuran / 2 h / 20 °C 2: 255.2 g / hydrogen peroxide; trifluoroacetic anhydride / CH2Cl2 / 16 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 1.) NaH / 1.) THF, 0 deg C, 15 min, 2.) room temperature, 16 h 2: 90 percent / m-chloroperbenzoic acid / CH2Cl2 / 16 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 - 20 °C / Inert atmosphere 1.2: 24 h / 20 °C / Inert atmosphere 2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 25 °C / Inert atmosphere View Scheme |
4-fluoro-2-(trifluoromethyl)benzonitrile
Bicalutamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 97 percent / sodium hydride / dimethylformamide / 4 h / 20 °C 2: 98.6 percent / hydrogen peroxide; trifluoroacetic anhydride / CH2Cl2 / 1.67 h / 20 °C 3: sodium hydride / tetrahydrofuran / 2 h / 20 °C 4: 255.2 g / hydrogen peroxide; trifluoroacetic anhydride / CH2Cl2 / 16 h / 20 °C View Scheme |
4-amino-2-trifluoromethylbenzonitrile
Bicalutamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 81 percent / SOCl2 / N,N-dimethyl-acetamide / 0.17 h / 20 °C 2.1: BuLi / tetrahydrofuran / 1 h 2.2: 90 percent / tetrahydrofuran / 0.33 h View Scheme | |
Multi-step reaction with 4 steps 1: N,N-dimethylacetamide / 4 h / Ambient temperature 2: m-chloroperbenzoic acid, 2,6-di-tert-butyl-4-methylphenol / 1,1,1-trichloro-ethane / 6 h / Heating 3: 1.) NaH / 1.) THF, 0 deg C, 15 min, 2.) room temperature, 16 h 4: 90 percent / m-chloroperbenzoic acid / CH2Cl2 / 16 h / Ambient temperature View Scheme | |
Multi-step reaction with 4 steps 1.1: N,N-dimethyl acetamide / 3 h / 20 °C / Inert atmosphere 2.1: dihydrogen peroxide; trifluoroacetic anhydride / dichloromethane / 24 h / 20 °C / Inert atmosphere 3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 - 20 °C / Inert atmosphere 3.2: 24 h / 20 °C / Inert atmosphere 4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 25 °C / Inert atmosphere View Scheme |
4-Fluorothiophenol
Bicalutamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) NaH / 1.) THF, 0 deg C, 15 min, 2.) room temperature, 16 h 2: 90 percent / m-chloroperbenzoic acid / CH2Cl2 / 16 h / Ambient temperature View Scheme |
N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide
Bicalutamide
Conditions | Yield |
---|---|
With dihydrogen peroxide In dichloromethane; ethyl acetate; Petroleum ether |
N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide
Bicalutamide
Conditions | Yield |
---|---|
In methanol; water; ethyl acetate; Petroleum ether |
4-fluorobenzenesulfinic acid
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide
Bicalutamide
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 50℃; pH=10; Kinetics; aq. buffer; |
N-[4-cyano-3-(trifluoromethyl)-phenyl]-2,3-dihydroxy-2-methyl-propionamide
Bicalutamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dichloromethane; triethylamine / 0 - 20 °C 2: sodium iodide / acetone / 48 h / Heating / reflux 3: dimethyl sulfoxide / 8 h / 60 °C View Scheme | |
Multi-step reaction with 3 steps 1: dichloromethane; triethylamine / 0.5 h / 0 - 20 °C 2: sodium iodide / acetone / 21 h / Heating / reflux 3: dimethyl sulfoxide / 8 h / 60 °C View Scheme |
N-[4-cyano-3-(trifluoromethyl)phenyl]-2,2,4-trimethyl-1,3-dioxolane-4-carboxamide
Bicalutamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: toluene-4-sulfonic acid / methanol / 18 h / 20 °C 2: dichloromethane; triethylamine / 0 - 20 °C 3: sodium iodide / acetone / 48 h / Heating / reflux 4: dimethyl sulfoxide / 8 h / 60 °C View Scheme | |
Multi-step reaction with 4 steps 1: toluene-4-sulfonic acid / methanol / 18 h / 20 °C 2: dichloromethane; triethylamine / 0.5 h / 0 - 20 °C 3: sodium iodide / acetone / 21 h / Heating / reflux 4: dimethyl sulfoxide / 8 h / 60 °C View Scheme |
N-[4-cyano-3-trifluoromethyl-phenyl]-2-hydroxy-3-methanesulfonyloxy-2-methyl-propionamide
Bicalutamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium iodide / acetone / 21 h / Heating / reflux 2: dimethyl sulfoxide / 8 h / 60 °C View Scheme |
(+/-)-N-[4-cyano-3-trifluoromethyl-phenyl]-2-hydroxy-3-[4-methylphenyl-sulfonyloxy]-2-methyl-propionamide
Bicalutamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium iodide / acetone / 48 h / Heating / reflux 2: dimethyl sulfoxide / 8 h / 60 °C View Scheme |
4-Chlorophenylboronic acid
Bicalutamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: nickel(II) bromide dimethoxyethane; 3,4,7,8-Tetramethyl-o-phenanthrolin; 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate; lithium tert-butoxide / 16 h / 100 °C 2: N-ethyl-N,N-diisopropylamine / water / 48 h / 100 °C View Scheme |
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide
Bicalutamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In water at 100℃; for 48h; |
bis(4-fluorophenyl)iodonium triflate
Bicalutamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: copper diacetate; ammonia / 1,2-dimethoxyethane; methanol / 1 h / 20 °C 2: cesium fluoride / water / 15 h / 90 °C View Scheme |
4-fluoro-1-iodobenzene
Bicalutamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: (2S,4R)-N-(2,6-dimethylphenyl)-4-hydroxypyrrolidine-2-carboxamide; copper(l) iodide; potassium phosphate / dimethyl sulfoxide / 24 h / 35 °C 2: cesium fluoride / water / 15 h / 90 °C View Scheme |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 25℃; for 17h; | 82% |
silver(I) hexafluorophosphate
Bicalutamide
Conditions | Yield |
---|---|
In methanol for 12h; Reflux; Darkness; | 61.3% |
Conditions | Yield |
---|---|
With C10H12O2NiC8H12-1,5-cyclo; triphenylborane; diphenyl(methyl)phosphine In 1-methyl-pyrrolidin-2-one at 80℃; for 18h; Inert atmosphere; Glovebox; Sealed tube; | 57% |
silver(I) hexafluorophosphate
Bicalutamide
Conditions | Yield |
---|---|
In methanol for 12h; Reflux; Darkness; | 52.3% |
cis-dichlorobis(2,2′-bipyridine)ruthenium(II)
silver(I) hexafluorophosphate
Bicalutamide
Conditions | Yield |
---|---|
In methanol for 12h; Reflux; Darkness; | 50.6% |
Bicalutamide
Conditions | Yield |
---|---|
With 2,2,6,6-tetramethyl-piperidine; 1,2,2,6,6-pentamethylpiperidine; 4-sulfanylphenol; 1,3-dicyano-2,4,5,6-tetrakis(N,N-diphenylamino)-benzene In 1,2-dichloro-ethane at 25℃; for 12h; Sealed tube; Irradiation; Inert atmosphere; Overall yield = 50 percentSpectr.; | A 43% B n/a |
Bicalutamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: n-butyllithium / tetrahydrofuran / 3 h / -78 - 0 °C 2: hydrogen / palladium 10% on activated carbon / methanol / 20 °C 3: sodium hydroxide / di-isopropyl ether; methanol / 3.5 h / 0 - 20 °C View Scheme |
Bicalutamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: n-butyllithium / tetrahydrofuran / 3 h / -78 - 0 °C 2: hydrogen / palladium 10% on activated carbon / methanol / 20 °C 3: potassium hydroxide / methanol / 2 h / 0 - 20 °C View Scheme |
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