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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

good price,good quality,good service Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaos

Bicalutamide

Cas:90357-06-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Hubei Vanz Pharm Co.,Ltd

ISO Factory/Good qualityAppearance:off white Storage:dry and cool place Package:10G/BAG; 1KG/BAG ;25KG/DRUM Application:Active pharaceutical ingredients Transportation:BY SEA,AIR,EXPRESS Port:shenzhen/shanghai

Bicalutamide

Cas:90357-06-5

Min.Order:0

Negotiable

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Bicalutamide Manufacturer/High quality/Best price/In stock

Cas:90357-06-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

We are very compeitive on Bicalutamide.Our mfr with DMF document. Product Name: Bicalutamide CAS: 90357-06-5 MF: C18H14F4N2O4S MW: 430.37 EINECS: 200-001-8 Product Categories:

factory supply DMF Bicalutamide

Cas:90357-06-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Bicalutamide supplier in China

Cas:90357-06-5

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

Bicalutamide 1.CAS RN: 90357-06-5 2.English Name:Bicalutimide Chemical name: N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxyl-2- methylpropanemide Synonyms: Bicalutamide (Subject to

CAS:90357-06-5 Bicalutamide low price

Cas:90357-06-5

Min.Order:1 Kilogram

Negotiable

Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Bicalutamide Cas 90357-06-5 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white powder Storage:cool dry place Package:1kg/foil bag;25kg

Manufacturer high quality Bicalutamide Cas 90357-06-5 with good price

Cas:90357-06-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Bicalutamide

Cas:90357-06-5

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Bicalutamide 90357-06-5 GMP Manufacturer

Cas:90357-06-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan

Bicalutamide

Cas:90357-06-5

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Bicalutamide

Cas:90357-06-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Bicalutamide

Cas:90357-06-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Bicalutamide CAS NO:90357-06-5 Grade:Medical scientific research and export Molecular formula:C18H14F4N2O4S   Molecular weight:430.37 Product Quality 12 years of chemical raw materials Mature operation of the industry System stabi

Bicalutamide /cas:90357-06-5 /Raw material spot

Cas:90357-06-5

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Bicalutamide

Cas:90357-06-5

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Bicalutamide

Cas:90357-06-5

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 90357-06-5 with best quality

Cas:90357-06-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Payment methods: bitcoin,T/T,LTC,ETH,USDT,Western Union,Wire transfer,Monero; Shipping Express:DHL,FedEx,UPS,TNT,EMS; How to make an order: after our clients confirm the payment,then the tracking number and parcel pictures will be sent to our clients

Bicalutamide

Cas:90357-06-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Bicalutamide CAS90357-06-5

Cas:90357-06-5

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Items Result Appearance Powder Content 99.0%min Moisture <0.04% Brand

Bicalutamide 90357-06-5

Cas:90357-06-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to off-white powder Storage:R.T Package:25kg/Barrel Application:Antiandrogens Transportation:Express/Sea/Air Port:Any port in China

China factory Bicalutamide cas:90357-06-5

Cas:90357-06-5

Min.Order:1 Kilogram

FOB Price: $489.0 / 665.0

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White crystal Storage:Store in sealed containers at cool & d

99% Content Bicalutamide CAS 90357-06-5 Anti-Prostate Cancer Drug

Cas:90357-06-5

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Manufacturers Supply High Quality Bicalutamide Raw Material with Best Price CAS No. 90357-06-5

Cas:90357-06-5

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:white powder Storage:storage in a dr

top quality Bicalutamide 90357-06-5

Cas:90357-06-5

Min.Order:100 Gram

FOB Price: $10.0

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

High Quality API bicalutamide Powder Anti-cancer raw materials

Cas:90357-06-5

Min.Order:10 Gram

FOB Price: $0.5

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Good quality 90357-06-5

Cas:90357-06-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Bicalutamide CAS:90357-06-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Bicalutamide CAS:90357-06-5

Cas:90357-06-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Bicalutamide

Cas:90357-06-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Bicalutamide

Cas:90357-06-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

factory Bicalutamide 90357-06-5 in China Bicalutamide Chemical Properties Melting point 191-193°C storage temp. Store at RT solubility

factory Bicalutamide 90357-06-5 in China

Cas:90357-06-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Bicalutamide 90357-06-5

Cas:90357-06-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide
90356-78-8

N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Stage #1: N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide With potassium permanganate; tetra(n-butyl)ammonium hydrogensulfate In water; ethyl acetate at 25 - 30℃; for 2.5h;
Stage #2: With sodium metabisulfite In water; ethyl acetate for 1h;
100%
With (dimethyl dioctadecylammonium)3[PW12O40]; dihydrogen peroxide In dichloromethane at 25℃; for 0.416667h; Catalytic behavior; Temperature; Reagent/catalyst;99.1%
Stage #1: N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide With dihydrogen peroxide; sodium tungstate; methanesulfonic acid In water; ethyl acetate at 25 - 32℃; for 6h;
Stage #2: With sodium thiosulfate In water; ethyl acetate for 0.5h; Product distribution / selectivity;
98%
4-Fluorothiophenol
371-42-6

4-Fluorothiophenol

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide
90357-51-0

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Stage #1: 4-Fluorothiophenol; N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In water; ethyl acetate at 25 - 30℃; for 3h;
Stage #2: With potassium permanganate In water; ethyl acetate for 2.5h;
Stage #3: With sodium metabisulfite In water; ethyl acetate at 50℃; for 1h; Product distribution / selectivity;
97.3%
N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide
90356-78-8

N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide

A

N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfinyl-2-hydroxy-2-methyl-propanamide
945419-64-7

N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfinyl-2-hydroxy-2-methyl-propanamide

B

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
With urea hydrogen peroxide adduct In tetrahydrofuran; formic acid; water at 27 - 35℃; for 1h;A 0.08 %Chromat.
B 96%
1-(methylsufonyl)-4-fluorobenzene
455-15-2

1-(methylsufonyl)-4-fluorobenzene

N-(4-cyano-3-(trifluoromethyl)phenyl)-2-oxo propanamide
87310-69-8

N-(4-cyano-3-(trifluoromethyl)phenyl)-2-oxo propanamide

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Stage #1: 1-(methylsufonyl)-4-fluorobenzene With n-butyllithium In tetrahydrofuran at -78℃; for 0.333333h;
Stage #2: N-(4-cyano-3-trifluoromethyl-phenyl)-2-oxo-propionamide In tetrahydrofuran at -78 - 20℃; Further stages.;
95%
Stage #1: 1-(methylsufonyl)-4-fluorobenzene With n-butyllithium In tetrahydrofuran for 1h;
Stage #2: N-(4-cyano-3-trifluoromethyl-phenyl)-2-oxo-propionamide In tetrahydrofuran for 0.333333h;
90%
With n-butyllithium In tetrahydrofuran1.67 g (90%)
3-chloro-benzenecarboperoxoic acid
937-14-4

3-chloro-benzenecarboperoxoic acid

N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide
90356-78-8

N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
In dichloromethane94%
(((tert-butyldimethylsilyl)oxy)methyl)(4-fluorophenyl)sulfone

(((tert-butyldimethylsilyl)oxy)methyl)(4-fluorophenyl)sulfone

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide
90357-51-0

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
With cesium fluoride In water at 90℃; for 15h;93%
With cesium fluoride In water at 90℃; for 15h; Inert atmosphere;93%
4-Fluorothiophenol
371-42-6

4-Fluorothiophenol

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide
90357-53-2

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Stage #1: 4-Fluorothiophenol; N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide With oxygen In acetonitrile at 45℃; for 10h;
Stage #2: With oxone In acetonitrile for 18h; Temperature; Reagent/catalyst;
88%
Stage #1: 4-Fluorothiophenol; N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide With oxygen In ethanol at 45℃; Green chemistry;
Stage #2: With Oxone In ethanol at 45℃; Green chemistry;
68%
4-cyano-3-(trifluoromethyl)phenylisocyanide
1067225-62-0

4-cyano-3-(trifluoromethyl)phenylisocyanide

1-(4-fluorophenylsulfonyl)propan-2-one
432-98-4

1-(4-fluorophenylsulfonyl)propan-2-one

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Stage #1: 4-cyano-3-(trifluoromethyl)phenylisocyanide With titanium tetrachloride In dichloromethane for 1h; Passerini reaction; Cooling with ice;
Stage #2: 1-(4-fluorophenylsulfonyl)propan-2-one In dichloromethane for 3h; Passerini reaction;
Stage #3: With water In dichloromethane for 0.333333h;
66%
sodium 4-fluorobenzenesulfinate
824-80-6

sodium 4-fluorobenzenesulfinate

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide
90357-51-0

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
With tetrabutylammomium bromide In chloroform; water for 96h; Heating / reflux;48%
With sulfuric acid In ethanol for 6h; Heating / reflux;
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-3-iodo-2-methylpropanamide
216665-25-7

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-3-iodo-2-methylpropanamide

sodium 4-fluorobenzenesulfinate
824-80-6

sodium 4-fluorobenzenesulfinate

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
In dimethyl sulfoxide at 60℃; for 8h;23%
(4-methanesulfonyl-phenyl)-N,N,N-trimethyl-ammonium trifluoromethanesulfonate

(4-methanesulfonyl-phenyl)-N,N,N-trimethyl-ammonium trifluoromethanesulfonate

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 87 percent / tetrabutylammonium fluoride / dimethylsulfoxide / 0.5 h / 90 °C
2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C
2.2: 95 percent / tetrahydrofuran / -78 - 20 °C
View Scheme
(4-methanesulfonylphenyl)-N,N-dimethyl-amine
33599-22-3

(4-methanesulfonylphenyl)-N,N-dimethyl-amine

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 31 percent / CH2Cl2 / 20 h / Heating
2.1: 87 percent / tetrabutylammonium fluoride / dimethylsulfoxide / 0.5 h / 90 °C
3.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C
3.2: 95 percent / tetrahydrofuran / -78 - 20 °C
View Scheme
4-Fluorothiophenol
371-42-6

4-Fluorothiophenol

o-CHO-C6H4-X (X=NO2 or F)

o-CHO-C6H4-X (X=NO2 or F)

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride / tetrahydrofuran / 2 h / 20 °C
2: 255.2 g / hydrogen peroxide; trifluoroacetic anhydride / CH2Cl2 / 16 h / 20 °C
View Scheme
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide
90357-53-2

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 98.6 percent / hydrogen peroxide; trifluoroacetic anhydride / CH2Cl2 / 1.67 h / 20 °C
2: sodium hydride / tetrahydrofuran / 2 h / 20 °C
3: 255.2 g / hydrogen peroxide; trifluoroacetic anhydride / CH2Cl2 / 16 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: m-chloroperbenzoic acid, 2,6-di-tert-butyl-4-methylphenol / 1,1,1-trichloro-ethane / 6 h / Heating
2: 1.) NaH / 1.) THF, 0 deg C, 15 min, 2.) room temperature, 16 h
3: 90 percent / m-chloroperbenzoic acid / CH2Cl2 / 16 h / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
1.1: dihydrogen peroxide; trifluoroacetic anhydride / dichloromethane / 24 h / 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 - 20 °C / Inert atmosphere
2.2: 24 h / 20 °C / Inert atmosphere
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 25 °C / Inert atmosphere
View Scheme
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide
90357-51-0

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride / tetrahydrofuran / 2 h / 20 °C
2: 255.2 g / hydrogen peroxide; trifluoroacetic anhydride / CH2Cl2 / 16 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 1.) NaH / 1.) THF, 0 deg C, 15 min, 2.) room temperature, 16 h
2: 90 percent / m-chloroperbenzoic acid / CH2Cl2 / 16 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 - 20 °C / Inert atmosphere
1.2: 24 h / 20 °C / Inert atmosphere
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 25 °C / Inert atmosphere
View Scheme
4-fluoro-2-(trifluoromethyl)benzonitrile
194853-86-6

4-fluoro-2-(trifluoromethyl)benzonitrile

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 97 percent / sodium hydride / dimethylformamide / 4 h / 20 °C
2: 98.6 percent / hydrogen peroxide; trifluoroacetic anhydride / CH2Cl2 / 1.67 h / 20 °C
3: sodium hydride / tetrahydrofuran / 2 h / 20 °C
4: 255.2 g / hydrogen peroxide; trifluoroacetic anhydride / CH2Cl2 / 16 h / 20 °C
View Scheme
4-amino-2-trifluoromethylbenzonitrile
654-70-6

4-amino-2-trifluoromethylbenzonitrile

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 81 percent / SOCl2 / N,N-dimethyl-acetamide / 0.17 h / 20 °C
2.1: BuLi / tetrahydrofuran / 1 h
2.2: 90 percent / tetrahydrofuran / 0.33 h
View Scheme
Multi-step reaction with 4 steps
1: N,N-dimethylacetamide / 4 h / Ambient temperature
2: m-chloroperbenzoic acid, 2,6-di-tert-butyl-4-methylphenol / 1,1,1-trichloro-ethane / 6 h / Heating
3: 1.) NaH / 1.) THF, 0 deg C, 15 min, 2.) room temperature, 16 h
4: 90 percent / m-chloroperbenzoic acid / CH2Cl2 / 16 h / Ambient temperature
View Scheme
Multi-step reaction with 4 steps
1.1: N,N-dimethyl acetamide / 3 h / 20 °C / Inert atmosphere
2.1: dihydrogen peroxide; trifluoroacetic anhydride / dichloromethane / 24 h / 20 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 - 20 °C / Inert atmosphere
3.2: 24 h / 20 °C / Inert atmosphere
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 25 °C / Inert atmosphere
View Scheme
4-Fluorothiophenol
371-42-6

4-Fluorothiophenol

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) NaH / 1.) THF, 0 deg C, 15 min, 2.) room temperature, 16 h
2: 90 percent / m-chloroperbenzoic acid / CH2Cl2 / 16 h / Ambient temperature
View Scheme
sodium tungstate

sodium tungstate

sodium thiosulfate

sodium thiosulfate

N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide
90356-78-8

N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
With dihydrogen peroxide In dichloromethane; ethyl acetate; Petroleum ether
[2KHSO5·KHSO4·K2SO4 salt]

[2KHSO5·KHSO4·K2SO4 salt]

sodium thiosulfate

sodium thiosulfate

N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide
90356-78-8

N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
In methanol; water; ethyl acetate; Petroleum ether
4-fluorobenzenesulfinic acid
369-51-7

4-fluorobenzenesulfinic acid

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide
90357-51-0

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
In dimethyl sulfoxide at 50℃; pH=10; Kinetics; aq. buffer;
N-[4-cyano-3-(trifluoromethyl)-phenyl]-2,3-dihydroxy-2-methyl-propionamide
316373-92-9

N-[4-cyano-3-(trifluoromethyl)-phenyl]-2,3-dihydroxy-2-methyl-propionamide

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dichloromethane; triethylamine / 0 - 20 °C
2: sodium iodide / acetone / 48 h / Heating / reflux
3: dimethyl sulfoxide / 8 h / 60 °C
View Scheme
Multi-step reaction with 3 steps
1: dichloromethane; triethylamine / 0.5 h / 0 - 20 °C
2: sodium iodide / acetone / 21 h / Heating / reflux
3: dimethyl sulfoxide / 8 h / 60 °C
View Scheme
N-[4-cyano-3-(trifluoromethyl)phenyl]-2,2,4-trimethyl-1,3-dioxolane-4-carboxamide
512776-91-9

N-[4-cyano-3-(trifluoromethyl)phenyl]-2,2,4-trimethyl-1,3-dioxolane-4-carboxamide

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: toluene-4-sulfonic acid / methanol / 18 h / 20 °C
2: dichloromethane; triethylamine / 0 - 20 °C
3: sodium iodide / acetone / 48 h / Heating / reflux
4: dimethyl sulfoxide / 8 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1: toluene-4-sulfonic acid / methanol / 18 h / 20 °C
2: dichloromethane; triethylamine / 0.5 h / 0 - 20 °C
3: sodium iodide / acetone / 21 h / Heating / reflux
4: dimethyl sulfoxide / 8 h / 60 °C
View Scheme
N-[4-cyano-3-trifluoromethyl-phenyl]-2-hydroxy-3-methanesulfonyloxy-2-methyl-propionamide
316373-95-2

N-[4-cyano-3-trifluoromethyl-phenyl]-2-hydroxy-3-methanesulfonyloxy-2-methyl-propionamide

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium iodide / acetone / 21 h / Heating / reflux
2: dimethyl sulfoxide / 8 h / 60 °C
View Scheme
(+/-)-N-[4-cyano-3-trifluoromethyl-phenyl]-2-hydroxy-3-[4-methylphenyl-sulfonyloxy]-2-methyl-propionamide
316373-98-5

(+/-)-N-[4-cyano-3-trifluoromethyl-phenyl]-2-hydroxy-3-[4-methylphenyl-sulfonyloxy]-2-methyl-propionamide

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium iodide / acetone / 48 h / Heating / reflux
2: dimethyl sulfoxide / 8 h / 60 °C
View Scheme
4-Chlorophenylboronic acid
1679-18-1

4-Chlorophenylboronic acid

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: nickel(II) bromide dimethoxyethane; 3,4,7,8-Tetramethyl-o-phenanthrolin; 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate; lithium tert-butoxide / 16 h / 100 °C
2: N-ethyl-N,N-diisopropylamine / water / 48 h / 100 °C
View Scheme
C6H4ClO2S(1-)*Li(1+)

C6H4ClO2S(1-)*Li(1+)

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide
90357-51-0

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In water at 100℃; for 48h;
bis(4-fluorophenyl)iodonium triflate
732306-64-8

bis(4-fluorophenyl)iodonium triflate

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper diacetate; ammonia / 1,2-dimethoxyethane; methanol / 1 h / 20 °C
2: cesium fluoride / water / 15 h / 90 °C
View Scheme
4-fluoro-1-iodobenzene
352-34-1

4-fluoro-1-iodobenzene

Bicalutamide
90357-06-5

Bicalutamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (2S,4R)-N-(2,6-dimethylphenyl)-4-hydroxypyrrolidine-2-carboxamide; copper(l) iodide; potassium phosphate / dimethyl sulfoxide / 24 h / 35 °C
2: cesium fluoride / water / 15 h / 90 °C
View Scheme
pent-4-enoic acid
591-80-0

pent-4-enoic acid

Bicalutamide
90357-06-5

Bicalutamide

C23H20F4N2O5S

C23H20F4N2O5S

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 25℃; for 17h;82%
Ru(2,2'-biquinoline)dichlorid

Ru(2,2'-biquinoline)dichlorid

silver(I) hexafluorophosphate
26042-63-7

silver(I) hexafluorophosphate

Bicalutamide
90357-06-5

Bicalutamide

C72H52F8N8O8RuS2(2+)*2F6P(1-)

C72H52F8N8O8RuS2(2+)*2F6P(1-)

Conditions
ConditionsYield
In methanol for 12h; Reflux; Darkness;61.3%
2(13)CN(1-)*Zn(2+)

2(13)CN(1-)*Zn(2+)

Bicalutamide
90357-06-5

Bicalutamide

C17(13)CH14F4N2O4S

C17(13)CH14F4N2O4S

Conditions
ConditionsYield
With C10H12O2NiC8H12-1,5-cyclo; triphenylborane; diphenyl(methyl)phosphine In 1-methyl-pyrrolidin-2-one at 80℃; for 18h; Inert atmosphere; Glovebox; Sealed tube;57%
[Ru(1,10-phenanthroline)2Cl2]

[Ru(1,10-phenanthroline)2Cl2]

silver(I) hexafluorophosphate
26042-63-7

silver(I) hexafluorophosphate

Bicalutamide
90357-06-5

Bicalutamide

C60H44F8N8O8RuS2(2+)*2F6P(1-)

C60H44F8N8O8RuS2(2+)*2F6P(1-)

Conditions
ConditionsYield
In methanol for 12h; Reflux; Darkness;52.3%
cis-dichlorobis(2,2′-bipyridine)ruthenium(II)
345911-20-8, 19542-80-4, 158060-65-2, 34795-02-3, 15746-57-3

cis-dichlorobis(2,2′-bipyridine)ruthenium(II)

silver(I) hexafluorophosphate
26042-63-7

silver(I) hexafluorophosphate

Bicalutamide
90357-06-5

Bicalutamide

C56H44F8N8O8RuS2(2+)*2F6P(1-)

C56H44F8N8O8RuS2(2+)*2F6P(1-)

Conditions
ConditionsYield
In methanol for 12h; Reflux; Darkness;50.6%
Bicalutamide
90357-06-5

Bicalutamide

A

N-(4-cyano-3-(difluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide

N-(4-cyano-3-(difluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide

B

C18H16F2N2O4S

C18H16F2N2O4S

Conditions
ConditionsYield
With 2,2,6,6-tetramethyl-piperidine; 1,2,2,6,6-pentamethylpiperidine; 4-sulfanylphenol; 1,3-dicyano-2,4,5,6-tetrakis(N,N-diphenylamino)-benzene In 1,2-dichloro-ethane at 25℃; for 12h; Sealed tube; Irradiation; Inert atmosphere; Overall yield = 50 percentSpectr.;A 43%
B n/a
Bicalutamide
90357-06-5

Bicalutamide

phosphoric acid ester dicalcium salt of bicalutamide

phosphoric acid ester dicalcium salt of bicalutamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: n-butyllithium / tetrahydrofuran / 3 h / -78 - 0 °C
2: hydrogen / palladium 10% on activated carbon / methanol / 20 °C
3: sodium hydroxide / di-isopropyl ether; methanol / 3.5 h / 0 - 20 °C
View Scheme
Bicalutamide
90357-06-5

Bicalutamide

C18H13F4N2O7PS(2-)*2K(1+)

C18H13F4N2O7PS(2-)*2K(1+)

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: n-butyllithium / tetrahydrofuran / 3 h / -78 - 0 °C
2: hydrogen / palladium 10% on activated carbon / methanol / 20 °C
3: potassium hydroxide / methanol / 2 h / 0 - 20 °C
View Scheme
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