SummaryHerein, we report the preparation of a series of surfactant-free nanostructured sodium tantalum oxide using NaTa(OC3H7)6 as a single precursor. The reaction conditions for the novel synthetic method were optimized and the morphology and crystal structure of the prepared materials were inv...

The performance and durability of PEMFCs highly depend on the catalyst support material. Traditionally, carbon is being used as support but its susceptibility to corrosion makes it less favorable for fuel cell applications. The weak interaction between PtC leads to the non-uniform distribution o...

Tantalum(V) propoxide (Ta(OPrn)5), isopropoxide (Ta(OPri)5) and butoxide(Ta(OBun)5) were synthesized by electrochemical reactions of corresponding alcohol at sacrificial tantalum anode in the presence of tetraethylammonium chloride as a conductive additive. The pure products were isolated by red...

An in-situ forming implant formulation of naltrexone (NTX) was achieved based on a minimum initial burst release of NTX in the in-vitro release medium using a Box-Behnken design. Variables such as percent of copolymer by weight, copolymer composition (PLGA 756s: PLGA 504H), and percent ethyl hep...

Deoxygenation of methyl laurate was carried out over potassium FAU zeolites. The influence of the silicon/aluminum molar ratio was studied using K-USY (3.2), KNaY (2.6) and KNaX (1.1). Decreasing the Si/Al ratio increases the basicity of the zeolite, which improved the deoxygenation capacity by ...

Triheptanoin, the medium-chain triglyceride of heptanoate, has been shown to be anticonvulsant and neuroprotective in several neurological disorders. In the gastrointestinal tract, triheptanoin is cleaved to heptanoate, which is then taken up by the blood and most tissues, including liver, heart...

A new series of (E)-1-(4-substituted)-3-(4-hydroxy-3-nitrophenyl) prop-2-en-1-one compounds have been synthesized by Claisen–Schmidt condensation reaction. Nonlinear optical characterization were carried out using z-scan technique with nanosecond pulses. These samples are found to exhibit stron...

ObjectiveExposure to lethal doses of radiation has severe effects on normal tissues. Exposed individuals experience a plethora of symptoms in different organ systems including the gastrointestinal (GI) tract, summarized as Acute Radiation Syndrome (ARS). There are currently no approved drugs for...

A green, fast and straightforward procedure for the synthesis of (E)-3-(3-(4-nitrophenyl)triaz-1-en-1-yl)-1H-pyrazole-4-carbonitrile is described in this paper. The method uses a coupling reaction between 4- nitrophenyl diazonium chloride and 5-aminopyrazole-4-carbonitrile. The structure is conf...

Electrochemical studies on several dimethylbenzo[a]pyrene (DMBP)1 derivatives were carried out at a platinum disk electrode employing cyclic voltammetric and chronopotentiometric techniques in (1:1) acetonitrile-benzene mixed solutions with tetra-n-butylammonium perchlorate as a supporting elect...

The 7-methylbenzo[a]pyrene (7-MBaP) was incubated with liver microsomes of rats pretreated with polychlorinated biphenyls (Aroclor 1254) (PCBs). Metabolites of 7-MBaP were isolated by both reversed-phase and normal-phase high performance liquid chromatography (HPLC) and were characterized by nuc...

The effects of benzo[a]pyrene, 6-hydroxymethylbenzo[a]pyrene, benzo[a]-pyrene-6-carboxaldehyde, 6-methylbenzo[a]pyrene, benzo[a]pyrene-6-carbonitrile and benzo[a]pyrene-6-carbonamide on urinary ascorbic acid excretion and hepatic tyrosine transaminase, aniline hydroxylase, aminopyrine N-demethyl...

Convenient syntheses of the previously unknown complete set of six isomeric monomethyl derivatives of benzo[e]pyrene, 1-, 2-, 3-, 4-, 9- and 10-methylbenzo[e]pyrene, are described. Syntheses of 1-, 2- and 3-methylbenzo[e]pyrene were accomplished through reaction of 7H-benzanthrene (or its 1-Me d...

The mutagenicity of benzo[a]pyrene (BP) and a number of methylated derivatives towards Salmonella typhimurium has been tested. The most mutagenic derivative tested was 6-methylbenzo[a]pyrene which produced about twice the number of revertants as did BP. 11-Methylbenzo[a]pyrene was slightly more ...

Determination of primary/intrinsic electron transfer rate (ket = 1/τet, s−1) in bimolecular photoinduced electron transfer reactions (PET) in solution phase monitoring fluorescence quenching is a controversial issue, predominantly due to constraint imposed by diffusion, and measurement of rate ...

Insertion of metals into various tetrapyrroles is catalysed by a group of enzymes called chelatases, e.g. nickel, cobalt, magnesium and ferro-chelatase. It has been proposed that catalytic metallation includes distorting the porphyrin substrate by the enzyme towards a transition state-like geome...

Benzodiazepinones are privileged scaffolds with activity against multiple therapeutically relevant biological targets. In support of our ongoing studies around allosteric modulators of metabotropic glutamate receptors (mGlus) we required the multigram synthesis of a β-ketoester key intermediate...

The controlled production of ZnO nanoparticles within an amorphous silica matrix is achieved using a new methodology consisting of four stages. First, precursor zinc glycerolate nanoparticles are produced within reversed micelles of glycerol in heptane stabilized by the surfactant Aerosol-OT (bi...

Nanoparticles synthesized using sol-gel method are promising agents for biomedical applications, in particular for the therapy and diagnosis of various diseases. Using silicon and zinc glycerolates as biocompatible precursors we synthesized by the sol-gel method a new bioactive silicon-zinc-cont...

Zinc glycerolate, Zn(gly), is prepared via a polyol-mediated synthesis with platelet-like morphology. These platelets exhibit diameters of 10–15 μm and a thickness of 100–300 nm. Via controlled thermal decomposition at 500–600 °C as-prepared Zn(gly) can be reacted to ZnO with the platelet-l...