Cardiopulmonary bypass triggers an ischemia-reperfusion injury with endothelial dysfunction in the pulmonary circulation which can result in pulmonary hypertension. Inhaled milrinone reduces this reperfusion phenomenon and two methods commonly available for administering it are simple jet and vi...
ObjectivesMilrinone pulmonary administration is used currently for the treatment of pulmonary hypertension. Several methods are available: simple jet nebulization, vibrating mesh nebulization, intratracheal instillation, and intratracheal atomization. The aim of this study was to explore the con...
ObjectiveTo report the authors’ 12 years of experience with intratracheal milrinone administration and to assess the efficacy and limitations of intratracheal milrinone bolus administration for the treatment of unexpected acute right ventricular (RV) failure in patients undergoing cardiac surgery.
A titanium alloy with 12 mass% molybdenum was produced using the cold crucible levitation melting technique. By varying the process parameters, microstructures with and without Mo segregation could be obtained. The effects of Mo segregation and ω-phase precipitation on the mechanical properties...
Mo promoted Ni/γ-Al2O3 catalysts were synthesized by an incipient wetness co-impregnation method. The micro-structure, surface composition and adsorption characteristics of these catalysts were investigated by N2 adsorption-desorption isotherms, XRD, HRTEM, XPS, TPR and dicyclopentadiene-TPD. T...
The promotional effect of Fe-Mo species introduced into HZSM-5 (Zeolyst Int., SiO2/Al2O3 ≈ 30) zeolite catalyst by the wetness impregnation method for the 1-hexene aromatization was investigated. The structure and catalytic performance for the aromatization of 1-hexene over xFeyMo-ZSM-5 catalys...
In clinical practice, glucocorticoids are often used with the aim of modulating the efficacy and toxicity of chemotherapeutic agents. However, how glucocorticoids modulate the pharmacological action of chemotherapeutic agents remains to be clarified. In this study, we generated glucocorticoid re...
The efficacy and toxicity of salvage chemotherapy with a combination of irinotecan hydrochloride (CPT-11) and mitomycin C (MMC) in elderly Japanese patients with gynecological malignancies are reported. Six patients, aged 75 years or older, two with stage IV uterine cervical cancer and four with...
Halloysite, a clay mineral with spiral-shape tubular crystal morphology and biocompatibility with the human body, could be applied for the encapsulation of various bioactive molecules, serving as a controlled drug delivery nanocarrier. In this work, halloysite nanotubes have been investigated as...
In this paper the voltammetric behaviour of the anticancer drug irinotecan (CPT-11), its injectable form in the clinical treatment regimen, irinotecan hydrochloride (CPT-11HCl), and its main metabolites (namely SN-38, SN-38G, APC, and NPC), and the natural chemical analogous camptothecin (CPT) w...
ObjectiveTo evaluate the toxicity and efficacy of irinotecan plus cisplatin neoadjuvant chemotherapy (NACT) for cervical cancer.
Because of the great interest for research on the potential use of cannabis preparations as co-medication for alleviation of toxic effects in cancer management, we investigated the influence of Δ9-tetrahydrocannabinol (Δ9-THC) to modulate irinotecan (CPT-11)-induced toxicity. Male Wistar rats ...
Irinotecan is highly effective in the treatment of metastatic colorectal cancer as well as many other cancers. However, irinotecan is known to cause severe diarrhea, which pose significant problems in patients undergoing irinotecan based chemotherapy. Dietary and herbal components have shown pro...
The aim of the present study was to investigate the effect of various transmembrane ammonium salt gradients and different lipid composition on the loading efficiency of liposomal formulations of irinotecan hydrochloride (CPT-11), their behavior in vivo and cytotoxicity. Among ammonium salts stud...
In this manuscript we aimed at the simultaneous separation and quantification of Gemcitabine and Irinotecan hydrochloride (injected both as single components and in combination) from Sprague Dawley rat plasma by using a validated method obtained through the use of a High Performance Liquid Chrom...
Irinotecan hydrochloride liposome injection (IHLI) is a formulation of anticancer drug irinotecan hydrochloride (CPT-11) entrapped in the aqueous core of liposomes. To understand the pharmacokinetic property and evaluate the relationship between pharmacokinetics and pharmacodynamics/toxicity of ...
A study is described of the reaction of trimethylbromosilane and trimethyliodosilane with various esters of phosphorothioic and phosphoroselenoic acids of general structures (RO)2(RY)P=O (I) and (RO)3P=Y (II) (Y = S or Se, R = alkyl). The reaction results in replacement of the R groups by trimet...
Eighteenweek-old mallard hens received 0, 10, 30, 90, or 270 ppm technical grade EPN (phenylphosphonothioic acid O-ethyl-O-4-nitrophenyl ester) in the diet for 90 days. Ataxia was first observed in the 270-ppm group after 16 days, in the 90-ppm group after 20 days, in the 30-ppm group after 38 d...
A series of alkyl and aryl phosphonyl, thiophosphonyl, and dithiophosphonyl derivatives of (S)- and (R)-glutamic acid were prepared and examined for inhibitory potency against glutamate carboxypeptidase (carboxypeptidase G). The acquisition of the phosphonamidodithioic acids and the individual p...
A series of phosphonothioic acid derivatives of (S)-2-hydroxyglutarate with various alkyl or aryl ligands to the central phosphorus atom was examined for stereoselective inhibition of the glutamate carboxypeptidase, carboxypeptidase G. The inhibitory potencies of these stereoisomers were compare...
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