Bacterial surface contamination is considered as one of the main causes of secondary infection. Herein, cationic polymers containing alkyl or aromatic quaternary phosphonium groups were synthesized via ring opening metathesis polymerization (ROMP) and successfully deposited onto a glass surface ...

Adsorption is a commonly used method for industrial wastewater treatment because of its low-cost, easy operation and high efficiency. In this work, chitosan was crosslinked and functionalized with a low-cost phosphonium salt, tetrakis(hydroxymethyl)phosphonium sulfate (THPS), to enhance its adso...

The human metabolism and pharmacokinetics of ethyl Nα-lauroyl-L-arginate hydrochloride (LAE), a new antimicrobial agent for use in foods have been investigated using both in vitro and in vivo techniques with 14C-LAE and 13C-LAE respectively. LAE was readily hydrolysed to the corresponding lauro...

Creatinine is the breakdown product of creatine, a key participant in the generation of ATP and is traditionally considered to be a biologically inert waste product. Based on our earlier work, we analyzed the effects of creatinine hydrochloride on the expression of tumor necrosis factor-alpha (T...

Androgen-induced masculinization of female aquatic biota poses concerns for natural population stability. This research evaluated the effects of a twelve day exposure of fadrozole hydrochloride on the metabolism and reproductive status of the unionid mussel Lampsilis fasciola. Although this comp...

The temperature dependence of infrared and Raman band intensities has been used to study conformational equilibrium in 2,2,5-trimethylhexane and 2,3,3,4-tetramethylpentane. The results are in good agreement with the results of molecular mechanics calculations.

A fundamental requirement for film generation in elastohydrodynamic lubrication (EHL) is that the viscosity of the liquid increase strongly with increase in pressure. The pressure dependence of viscosity influences both the thickness of the film separating the machine elements and the friction f...

In response to the 10th Industrial Fluid Properties Simulation Challenge, we report viscosity (η) estimates obtained with equilibrium molecular dynamics for 2,2,4-trimethylhexane at 293 K and over a range of pressures (P) from 0.1 MPa to 1000 MPa. The Mie Potentials for Phase Equilibria (MiPPE)...

This work is framed within AIChE's 10th Industrial Fluid Properties Simulation Challenge, with the aim of assessing the capability of molecular simulation methods and force fields to accurately predict the pressure dependence of the shear viscosity of 2,2,4-trimethylhexane at 293.15 K (20 °...

The pressure-dependent viscosity of 2,2,4-trimethylhexane is predicted using all-atom TEAM force field and the non-equilibrium periodic perturbation (PP) method. The viscosities predicted using the PP method do not show Newtonian plateau in the precision range of prediction for high-viscosity fl...

The Newtonian viscosity of 2,2,4-trimethylhexane at 293 K is determined at pressures from 0.1 MPa to 1000 MPa. Non-equilibrium molecular dynamics simulations are performed using AIREBO-M, an all-atom potential for hydrocarbons especially parameterized for high pressures. The steady-state shear s...

BTK and PI3Kδ play crucial roles in the progression of leukemia, and studies confirmed that the dual inhibition against BTK and PI3Kδ could provide superior anticancer agents to single targeted therapies. Herein, a new series of novel benzofuro[3,2-b]pyridin-2(1H)-one derivatives were optimize...

Background We recently confirmed that pemirolast potassium, an antiallergic agent, markedly inhibits migration and proliferation of vascular smooth muscle cells. It has also been reported that pemirolast inhibits intimal hyperplasia in animal experiments. Methods and Results To elucidate the pre...

ABSTRACTEosinophils are the key effector cells for allergic inflammation. In order to clarify drugs which can regulate eosinophil function, we investigated the direct effect of pemirolast potassium (anti-allergic drug) and FK506 (immunosupressant) on eosinophil degranulation and cytokine product...

New halogenated marine prostanoids, chlorovulone I, II and III were isolated from the stolonifer Clavularia viridis Quoy and Gaimard. The structure elucidation and the antitumor activity of chlorovulones were described.

Absolute configuration of chlorovulones, new halogenated marine prostanoids with an antitumor activity isolated from the stolonifer Clavularia viridis Quoy and Gaimard, has been established on the basis of the CD measurement of the chlorovulone derivatives and of the enantioselective synthesis o...

Fatty acids from natural sources (mostly seed oils) were isolated and assayed for their effect on the bioconversio of arachidonic acid into prostaglandin E2, using sheep vesicular gland microsomes. Homologues and isomers of the naturally occurring fatty acids, obtained by chemical modification a...

The following high performance liquid chromatography system was found suitable for separating most lipoxygenase metabolites of arachidonic acid: Techsphere 5-C18 column, eluting solvent methanol:water:acetic acid (65:35:0.06 v/v), pH 5.3. Comparisons with other packing materials and solvent syst...

In this work, a new series of imidazo[2,1-b]thiazole was designed and synthesized. The new compounds are having 3-fluorophenyl at position 6 of imidazo[2,1-b]thiazole and pyrimidine ring at position 5. The pyrimidine ring containing either amide or sulphonamide moiety attached to a linker (ethyl...

Objectives: The objectives of this study were to determine the pharmacokinetics of milrinone lactate in pediatric patients with septic shock and to determine whether a relationship exists between steady-state plasma milrinone concentrations and changes in hemodynamic variables. Study design: Thi...