Activated factor (F) VII is a vitamin K-dependent glycoprotein that initiates blood coagulation upon interaction with tissue factor. FVII deficiency is the most common of the rare congenital bleeding disorders. While the mutational pattern has been extensively characterized, the pathogenic molec...
A series of N-heterocyclic dipeptide aldehydes 4–13 have been synthesised and evaluated as inhibitors of ovine calpain 1 (o-CAPN1) and ovine calpain 2 (o-CAPN2). 5-Formyl-pyrrole 9 (IC50 values of 290 and 25 nM against o-CAPN1 and o-CAPN2, respectively) was the most potent and selective o-CAPN2...
This study examined the feasibility of using surface catalyzed Fenton treatment to remediate soil and groundwater contaminated by the chlorinated ethers, bis(2-chloroethyl) ether (BCEE) and bis(2-chloroethoxy) methane (BCEM). Parameters that affect the contaminant loss rate such as porewater pH,...
A new class of quinoline derivatives, bearing amino chains at C-4 and a styryl group at C-2, were tested on Leishmania donovani promastigotes and axenic and intracellular Leishmania pifanoi amastigotes. The introduction of the C-4 substituent improves the activity, which is due to interference w...
In a study directed towards development of novel Selective Estrogen Receptor Modulators (SERMs), 1-(4-(2-(dialkylamino)ethoxy)benzyl)-6-(4-hydroxypiperidin-1-yl)-2-naphthol and corresponding aryl methyl ethers were synthesized and bioevaluated against the estrogen-responsive human MCF-7 breast c...
The involvement of chemical alkylating agents in tumorigenesis and chemotherapy is well established and it was shown that one of the main sites of alkylation is the N-7 of guanine in DNA. Though excission of damaged bases is regarded as one of the repair mechanisms in damaged DNA there is a scar...
A simple and expeditious synthesis of S6-cyanoethyl-2′-deoxy-6-thioguanosine from 2′-deoxyguanosine has been accomplished in good yield and incorporated into several triple helix forming oligonucleotides using the solid-phase phosphoramidite chemistry.
Indian yellow has always been a mysterious pigment. In 1883, an eye-witness account of its production described it as a urinary sediment from cows fed a mango leaves rich diet; this same account describes a set of manufacturing materials and samples sent to the Royal Botanic Gardens, Kew (Englan...
Cadmium (Cd) is a toxic heavy metal that can pose a serious threat to aquatic organisms. To evaluate the physiological response and defense mechanism of fish intestine to Cd toxicity, yellow catfish (Pelteobagrus fulvidraco) were exposed to 0 (control), 50 μg/L and 200 μg/L Cd2+ for a period o...
1.1. The circulating crythrocytes of Rana catesbeiana tadpoles at varying metamorphic stages were studied by the phthalate-microcapillary technique of Danon & Marikovsky (1964 J. Lab. Clin. Med.64, 668–674) and by the method of Murphy (1973 J. Lab. Clin. Med.82, 334–341), which are used for th...
ObjectiveTo report a previously undescribed low-O2-affinity hemoglobin variant that is associated with chronic cyanosis.
Five hemoglobin components (a, I, II, III and IV) were isolated from the hemolysates of file tadpole, Rana catesbeiana. Component a was a monomeric molecule and the other four were tetrameric molecules. Component I predominating in younger tadpoles was replaced by component II during tadpole dev...
Endothelial cell growth factor(ECGF) is a potent polypeptyde mitogen which stimulates the growth of endothelial cells. The mitogenic effect of ECGF was inhibited by addition of recombinant interleukin-1 (rIL-1) α or β in a concentration dependent manner. The morphological change was not observ...
A bi-enzyme tracer direct competitive enzyme-linked immunosorbent assay (dc-ELISA) was developed based on anti-imidaclothiz and anti-thiacloprid antibodies. Several affected physicochemical factors were optimised, including methanol concentration, ionic strength and pH value. Under the optimised...
A direct quantum dots-based fluoroimmunoassay (QDFIA) and a time-resolved fluoroimmunoassay (TRFIA) for imidaclothiz (IMI) were developed by using the quantum dots (QDs)-labeled antibody and the europium (Eu3 +)-labeled antibody, respectively. After optimization, the half-maximal inhibition conc...
In this study, we isolated six phage-displayed peptides by biopanning phage-displayed peptide libraries on an immobilized anti-imidaclothiz monoclonal antibody. After analyzing the relative sensitivity of the individual phage-displayed peptides, we subsequently developed and optimized both a pha...
Imidaclothiz, a kind of neonicotinoid insecticides, is developed as a commercial pesticide in China and used for the control of sucking and biting insects, including aphids, whiteflies, beetles and some Lepidoptera species as well. In recent years, more and more attention has been focused on the...
Immunochromatographic strips (ICS) attract much attention as practical analytical tools, particularly for point of care testing. However, ICS suffer from insufficient sensitivity, especially for small molecules. Competitive assays developed with analyte peptidomimetics obtained from phage displa...
The purpose of the present study was to determine whether the motor impairment (myorelaxation/ataxia) induced by excitatory amino acid receptor antagonists was exaggerated by pretreatment with ethanol. The results were compared with those of γ-aminobutyric acidA (GABAA) receptor positive modula...
Ethyl 3,3,3-trifluoropropanoate and ethyl 2-bromo-3,3,3-trifluoropropanoate have been synthesized. A common intermediate ethyl 3-chloro (or 3-bromo)-3,3-difluoropropanoate is involved in the two syntheses. These esters are obtained by oxidation of the corresponding acetals resulting from the rad...
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