Although the fluoroquinolones share many properties, these agents differ in their ability to kill the same bacterial strain. The bactericidal activity of temafloxacin against a number of pathogens has been compared with that of other fluoroquinolones by determination of minimal bactericidal conc...

Temafloxacin (6-fluoro-7-piperazino-4-quinolone) is a new fluoroquinolone with a 7–8 hour half-life and rapid gastrointestinal absorption. These characteristics make it an ideal antimicrobial for once- or twice-daily oral dosing. With the exception of the central nervous system (CNS), temafloxa...

Temafloxacin hydrochloride (HCl) was studied in fenbufen-treated mice and for its effects on the locomotor activity of rats. Mice were observed for convulsions for 90 minutes after the administration of temafloxacin HCl (100 mg/kg orally [p.o.]), ciprofloxacin HCl (100 mg/kg p.o.), enoxacin (100...

Minor impurities in the antibacterial agent temafloxacin hydrochloride were determined using high-performance liquid chromatography. Manufacturing impurities and degradation products were separated using a reversed-phase system with gradient elution. Detector response was linear for the individu...

Tetrathiafulvalene (TTF) was one of the most widely studied heterocyclic systems. However, TTF itself was easily oxidized, which induced the low stability and limited its potential applications. Here, a TTF derivative, 2,3,6,7-tetrakis(2-cyanoethylthio)tetrathiafulvalene (TCE-TTF), was synthesiz...

Effect of substituent groups on a tetrathiafulvalene (TTF) unit for formation of organic-metal hybrid nanowires was studied. Depend on the substituent groups, the nanowires were obtained as a precipitate just by mixing TTF derivatives and HAuCl4 in CH3CN solution at room temperature via electron...

We present here a study of a tetrathiafulvalene derivative, tetrakis(octadecylthio)tetrathiafulvalene (TTFH), arranged in LB films together with a detailed characterization process by means of UV–vis, IR, SEM, and X-ray diffraction that has allowed us to propose a packing model. These films wer...

The formation of 6-hydroxymethylbenzo(α)pyrene from benzo(α)pyrene has been shown to be catalyzed by sonicates of rat liver microsomes. The biosynthetic pathway for the formation of the aryl hydroxymethyl groups appears to be a direct hydroxymethylation of the benzene ring and not involve 6-me...

SummaryThe carcinogenic hydrocarbons 6-hydroxymethylbenzo[a]pyrene (6-HOCH2-B[a]P) and 6-acetoxym8thylbenzo[a]pyrene (6-AcOCH2-B[a]P) were examined for their ability to bind to rat and calf thymus DNA. The data indicate there are no appreciable differences in the amount of binding to the two typ...

Pyrene- and anthracene-appended new crown ether derivatives have been synthesized by Schiff's base reaction, and cation complexation behavior was investigated by fluorescence spectroscopy measurements. Based on photo-induced electron transfer and intramolecular charge transfer mechanism, th...

Previous experiments have demonstrated that the intermediary metabolite 6-hydroxymethylbenzo[a] pyrene (HMBP) can be activated to the electrophilic mutagen, 6-sulfooxymethylbenzo[a]pyrene (SMBP), by rat and mouse liver PAPS-dependent sulfotransferase activity or by chemical synthesis. This aralk...

1,4-Diethyl-1,2,3,4-tetrahydro-7-hydroxyquinoxalin-6-carboxaldehyde was synthesized and condensed with substituted active methylene compounds to obtain a series of novel coumarin compounds. Solutions of the dyes in various solvents exhibited an orange hue and brilliant fluorescence and displayed...

The surface-enhanced Raman scattering (SERS) spectra of 4-(2-pyridylazo)resorcinol (PAR) and its Zn(II) and Cu(II) complexes were recorded using a hydroxylamine reduced silver colloid. Molecular geometry optimization, molecular electrostatic potential (MEP) distribution and vibrational frequenci...

A novel and low-cost optical sensor for heavy metal ion detection has been prepared by immobilizing 4-(2-pyridylazo)-resorcinol (PAR) on the functionalized hexagonal mesoporous silica (HMS) via N-trimethoxysilylpropyl-N,N,N-trimethylammonium chloride (TMAC). The successful fabrication of this op...

A green, novel and efficient solid phase extraction method based on the use of nano-alumina (nano-Al2O3) coated with sodium dodecyl sulfate (SDS) and modified with 4-(2-Pyridylazo) resorcinol (PAR) as a new adsorbent was developed for separation and preconcentration of trace amounts of Ni, Pb, C...

4-(2-Pyridylazo)resorcinol (PAR) is one of the most popular chromogenic chelator used in the determination of the concentrations of various metal ions from the d, p and f blocks and their affinities for metal ion-binding biomolecules. The most important characteristics of such a sensor are the m...

Nanolitre arrays of 4-(2-pyridylazo)resorcinol (PAR) reagent produced on polyethersulfone (PES) membrane surface has been utilized as a platform for rapid and precise determination of Cu2+ ions in water. The topography of the membrane surface was characterized by atomic force microscopy whereas ...

The H-bonding interaction of 1-(2-pyridylazo)-2-naphthol (PAN) and 4-(2-Pyridylazo) resorcinol (PAR) with chloranilic acid (CLA) have been considered spectroscopically in methanol solvent. PAN and PAR were used as a ligand and this two ligands has diverse application in spectrophotometric, chela...

Molecular charge-transfer (CT) complexation of the donor 4-(2-pyridylazo)resorcinol (1P) with selected nitroaromatic acceptors as like, 2,4-DNP, 3,5-DNSA, 3,5-DNBA, and PA have been studied in methanol at room temperature. Among the selected nitroaromatics we have isolated 1P-3,5-DNSA and 1P-PA ...

Two cuprous complexes with 1-(2-pyridylazo)-2-naphthol (PAN) or 4-(2-pyridylazo)resorcinol (PAR) and triphenylphosphines, [Cu(PAN)(PPh3)2]BF4 (1) and [Cu(PAR)(PPh3)2]BF4 (2), are described in this work. The structures of both compounds were characterized by NMR and UV–Vis spectroscopies, mass s...