BackgroundNateglinide is a d-phenylalanine derivative that stimulates fast insulin secretion with a short activity span. It has been suggested that the hypoglycemic effect of nateglinide is related to the glucose concentration, an aspect that still has not been completely evaluated in human beings.

Previous studies have shown that prolonged exposure to drugs, which act via blocking KATP channels, can desensitize the insulinotropic effects of drugs and nutrients acting via KATP channels. In this study, effects of prolonged exposure to diazoxide, a KATP channel opener, on beta cell function ...

We studied whether the rapid hypoglycemic action of nateglinide is associated with an increase in islet blood flow. Islet blood flow was measured using the two-colour microsphere method. Orally administered nateglinide with glucose acutely increased islet blood flow to levels greater than those ...

When stimulated with 6 mmol/L glucose, a minimal, transient insulin secretory response was observed from perifused rat islets. The inclusion of 5 μmol/L nateglinide significantly amplified release. Elevating glucose to 8 or 10 mmol/L resulted in an increasing insulin secretory response that was...

The enantioselective hydrolysis of (3RS,4RS)-trans-4-(4′-fluorophenyl)-6-oxo-piperidin-3-ethyl carboxylate (±)-2 was effected using a commercial preparation of lipase from C. antarctica A (CAL-A). We found that the hydrolytic activity of the lipase (immobilized on a number of very different su...

A group of racemic 4-aryl(heteroaryl)-1,4-dihydro-2,6-dimethyl-3-nitropyridines possessing nitric oxide donor O2-acetoxymethyl-1-(N-ethyl-N-methylamino, or 4-ethylpiperazin-1-yl)diazen-1-ium-1,2-diolate, C-5 ester substituents were synthesized by coupling the respective 4-aryl(heteroaryl)-1,4-di...

2-(Azidomethyl)phenyl isocyanide, 2-(CH2N3)C6H4NC (AziNC), coordinates to {M(CO)5} (M=W, Cr) fragments to afford the corresponding isocyanide complexes [M(CO)5(AziNC)] (M=W (1), Cr (2)). AziNC coordinates also to some Au(I) species such as [AuCl(AziNC)] (3), derived from the reaction of [AuCl(...

Magnetism-controlled fluorescent composite particles (nFe3O4@SiO2@QDs) were prepared as QD-anchored silica nanoparticles with magnetite cluster cores. First, citrate-capped magnetites (C-Fe3O4) were prepared by the co-precipitation method and subsequently complexed with 3-aminopropyl-trimethoxys...

Superparamagnetic nanoparticles with chemically modified chitosan has been proposed as a potential support for the immobilization of the androgen receptor (AR). The study involved comparison of different AR carriers like commercially available magnetic beads coated with silica (BcMag) and chitos...

The ligand diethylenetriamine (DETA) has been successfully coupled to carboxy-terminated magnetic particles, using the carbodiimide EDCI. Amine related peaks from DETA are seen in infrared measurements. The reaction with DETA involves a rearrangement of the self-assembled molecules of dibenzoic ...

In this work, three-dimensional (3D) amine-terminated ionic liquid (IL) covalently functionalized graphene/Pd composite aerogels are successfully fabricated via a facile and green reduction-inducing self-assembly method. The morphology and composition of the obtained 3D IL-rGO/Pd composite aerog...

In this study, graphene oxide (GO) as one of the newest member of carbon materials with high specific surface area was modified using poly(propylene imine) dendrimer (PPI) with a regular and highly branched structure containing eight amine terminated functional groups. The transmission electron ...

A bacteriophage-assisted magnetic separation method was developed for the isolation of Listeria monocytogenes from complex food matrices. The aim of this study is to understand the effect of phage immobilization methods and the magnetic particle sizes on the phage coupling and infectivity retent...

Epoxy resins are widely used thermosetting polymers, and they possess many merits including high rigidity, great dimension stability, and good chemical resistance, etc. However, the inherent brittleness limits their broad applications. In this work, amine-terminated hyperbranched polyamide (HBPA...

Background Previous clinical studies have shown that direct antithrombins can accelerate clot lysis after treatment with streptokinase in acute myocardial infarction (MI). Efegatran is a new direct antithrombin, which in experimental animals has been shown to enhance thrombolysis, reduce rate of...

Background Adjunctive therapies that increase the incidence of normal reperfusion after thrombolysis for acute myocardial infarction (MI) could enhance clinical outcomes. Direct thrombin inhibitors may offer an advantage over standard adjunctive therapies. Methods We randomized 336 patients with...

The synthesis of ethyl or methyl esters of 2-substituted 5-acetyl-1,6-dihydro-6-oxo-3-pyridinecarboxylic acids 2a-d, f and 5 by reaction of sodium acetoacetamide with ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates and ethyl 2-ethoxymethylene-4,4,4-trifluoro-3-oxobutanoate, respectively...

A series of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters (1–16) were synthesized and evaluated in vitro for their antimicrobial and anticancer potential. 6-Methyl-4-{1-[2-(4-nitro-phenylamino)-acetyl]-1H...

A facile solid-state synthesis of 2-(2-acetamidophenyl)-2-oxo-N phenyl acetamide and N-(2-(2-oxo-2(phenylamino)acetyl)phenyl)propionamide six derivatives has been achieved by microwave promoted condensation of N-acylisatin or N-propionylisatin with various aniline derivatives. The six products w...

A time-resolved (gated) luminescence-based method for the detection of some of N-acetyl amino acids, nucleobases, nucleotides, and DNA using terbium- 8-alkyl-2-oxo-2H-chromene-3-carbaldehyde (AOCC) complex in 1:2 metal: ligand ratio in microtiterplate format has been evolved. The linear range fo...