In the present investigation, a series of novel 4 (5-(10-(3-(N,N-dimethylamino)propyl)-10H-phenothiazine-3-yl)-1,3,4-thiadiazo-2-yl) Azo dye/Schiff base derivatives (5a-e & 6a-j) were synthesised by performing diazotization followed by coupling reaction between 4-(5-(10-(3-(N,N-dimethylamino)pro...

Heterocyclic compounds, such as hybrid tetrahydroquinoline and quinoline derivatives with phosphorated groups, have been prepared by multicomponent cycloaddition reaction between phosphorus-substituted anilines, aldehydes and styrenes. The antileishmanial activity of these compounds has been eva...

ABSTRACTThe pharmacologically active compound (33% reduction in rabbit intraocular pressure recovery rate assay) 1-ethyl-6-fluoro-1,2,3,4-tetrahydroquinoline (MC4), which showed ocular hypotensive action and had optimum physicochemical properties, was characterized for its ocular absorption and ...

An efficient synthetic route to non-racemic chiral 4-alkyl-1,2,3,4-tetrahydroquinoline is described. (4R)-4-Ethyl-1,2,3,4-tetrahydroquinoline was obtained by the organoaluminum promoted modified Beckmann rearrangement involving the oxime sulfonate of (3R)-3-ethylindan-1-one. The required optical...

ABSTRACTFour new molecular entities, N‐ethyl‐1,4‐benzoxazine (MC1), 1‐ethyl‐6‐hydroxymethyl‐1,2,3,4‐tetrahydroquinoline (MC2), (R,S)‐1‐ethyl‐6‐fluoro‐2‐methyl‐1,2,3,4‐tetrahydroquinoline (MC3), and 1‐ethyl‐6‐fluoro‐1,2,3,4‐tetrahydroquinoline MC4, based on the primary pharma...

Under the Pummerer reaction conditions, N-(1-cyclohexenyl)-N-methyl-α-(methylsulfinyl)acetamide (7a) cyclized in a 5-endo trigonal fashion through the intermediary cation (8) to give the tetrahydro-4H-oxindole (10). The reaction was successively applied to a novel synthesis of erythrinane skeleton.

Reactions of polyfluorobenzotrichlorides, benzotrichloride and α,α-dichloroperfluoroethylbenzene with sources of difluorocarbene and other dihalocarbenes lead to the formation of polyfluorostyrenes. Formation of polyfluorostyrenes is shown to proceed possibly by initial dihalocarbene insertion...

Cryo-electrochemistry in tetrahydrofuran (THF) with cyclic voltammetry and microdisc chronoamperometry has been applied to the reductive cleavage of the phenyl thioether: [(3-{[trans-4-(methoxymethoxy)cyclohexyl]oxy}propyl)thio]benzene, (RSPh) and has allowed the number of electrons participatin...

Benzyl and naphthylmethyl vinyl ethers are inert in LPDE medium, whereas hetcroaromntic methyl vinyl ethers, viz., 2-furyl and 2-thicnylmelhyl vinyl ethers undergo formal [1,3] rearrangement in LPDE medium.

4-[(2-{[(2-Furylmethyl)imino]methyl}-4-methoxyphenoxy)methyl]benzonitrile, a novel Schiff base compound, was prepared for the first time and its structural and vibrational properties were studied both experimentally and theoretically using FT-IR and XRD spectroscopic methods. FT-IR spectrum was ...

Six 4-substituted N-(2-furylmethyl)anilines have been studied by electron ionization (EI) mass spectrometry. The heterolytic dissociation of the C–N bond of the molecular ions was proposed as the route to the main fragment ion in the mass spectra, [C5H5O]+ (m/z=81). Reaction energies for this p...

Bacilysin is a dipeptide antibiotic composed of l-alanine and l-anticapsin. We recently reported partial purification and characterization of the bacilysin synthetase. In the present study, l-anticapsin in the in vitro reaction mixture was replaced by furfurylamine, norephedrine, glycine, and be...

Our research found that the 2-hydroxyacetophenone derivative is an outstanding linker between the 1,1-bistrifluoromethylcarbinol moiety and the imidazolidine-2,4-dione moiety to enhance the potency and β-selectivity of liver X receptor (LXR) agonist in our head-to-tail molecular design. The inc...

Double isopropoxides of niobium and tantalum with aluminium and gallium with general formulae, [MM′ (OPri)8] and [MM′2(OPri)11] have been prepared by refluxing their isopropoxides in isopropanol in molar ratio 1 : 1 and 1 : 2. These are soluble in organic solvents and are distilled under reduc...

The reactions are reported of NbX5 (X = Cl, Br), TiCl4 and Ti(OiPr)4 with a selection of carboxylic acids exhibiting a known biological role, in a chlorinated solvent. The reactions of NbX5 with acetylsalicylic acid (aspirin) proceeded with selective deacetylation of the organic reactant and for...

The sol-gel process allows the high throughput formation of transition metal oxide thin films. Microwave plasma annealing (MwPA) treatments have been performed on thin films of two different transition metal oxides, Ta2O5 and ZnO, selected as representatives of covalently and strongly ionic bond...

Niobium- and tantalum-containing mesoporous molecular sieves MCM-41 have been stud-ied by X-ray powder diffraction, 29Si MAS NMR, electron spin resonance, nitrogen adsorption and UV-Vis spectroscopy and compared with niobium- and tantalum-containing silicalite-1 The results of the physical chara...

Ta(OR)5 (R = Me(1), Et(2), Bun(3)) and Ta2O(OPri)8·PriOH (4) were obtained by the anodic oxidation of metallic tantalum in absolute alcohols in the presence of LiCl (electroconductive additive). Ta(OPri)5 (5) was isolated by distillation in the course of thermolysis of 4 under reduced pressure....

Tantalum-substituted Bi4Ti3O12 (Bi4Ti3-x/5Tax/5O12, BTTO) thin films were fabricated on Pt(111)/Ti/SiO2/Si(100) substrates by sol–gel technology. The effects of various processing parameters, including Ta content (x=0∼0.08) and annealing temperature (500∼800 °C), on the growth and properties...

Novel termetallic isopropoxides are reported which may be represented by the general formulae: [(PriO)3M(μ-OPri)2Be(μ-OPri)2Al(OPri)2], [(PriO)2M(μ-OPri)2Be(μ-OPri)2Al(OPri)2]2 [where M = Ti(IV), Zr(IV) and Hf(IV)] and [(PriO)4M(μ-OPri)2Be(μ-OPri)2Al(OPri)2] [where M = Nb(V) and Ta(V)]. At...