A red pigment was extracted and purified from the mycelia of a newly isolated strain of Penicillium sp., Penicillium sp. AZ, which produced a soluble violet pigment PP-V, 12-carboxyl-monascorubramine, in the culture fluid. The red pigment, PP-R, was determined by FAB-MS and 1H and 13C NMR to be ...

Four palladium(II) and platinum(II) saccharinate (sac) complexes with 2-(hydroxymethyl)pyridine (2-hmpy) and 2-(2-hydroxyethyl)pyridine (2-hepy), namely trans-[Pd(2-hmpy)2(sac)2]·H2O (1), trans-[Pt(2-hmpy)2(sac)2]·3H2O (2), trans-[Pd(2-hepy)2(sac)2] (3) and trans-[Pt(2-hepy)2(sac)2] (4), have ...

An efficient synthesis of 2-phenylamino-2-oxazolines 3 via cyclodesulfurization of N-(2-hydroxyethyl)-N′-phenylthioureas 2 by a one-pot reaction using p-toluenesulfonyl chloride (TsCl) and NaOH in very good yields is described.

The reaction of salicylaldehyde-(2-hydroxyethyl)imine (H2L), 1, with organoelement halides from group 13 and 14 leads to a variety of coordination compounds. Depending on the size of the central atom and the organic substituents, tetra-, penta- or hexacoordinated complexes emerge. When the centr...

In the present study, the synthesis of a range of novel 24-amino-25,26,27-trinorlanost-8-ene derivatives including 24-piperadino-trinorlanost-8-enes, 24-piperazino-trinorlanost-8-enes, 24-morpholino-trinorlanost-8-enes, and 24-diethylamino-trinorlanost-8-enes is reported and their cytotoxic and ...

Five new 1:1 metal complexes of highly selective acridine-based fluorophore 4,5-bis(N,N-di(2-hydroxyethyl)iminomethyl)acridine (BHIA) with Ag(I), Cu(II) and Cd(II) were synthesized, characterized and investigated by the methods of single crystal X-ray diffraction, IR, and Raman spectroscopy. Sin...

In the presence of Lewis acid TMSOTf, ring-opening reaction of aryl cyclopropyl ketone with arylaldehyde took place under mild conditions to give 2-(2-hydroxyethyl)-1,3-diarylpropenone in good yield. By protection of hydroxy group with triethylsilyl group (TES), the corresponding ring-opened pro...

A detailed study of substituent effects on the photochemical conversion of esters of (2-hydroxyethyl)benzophenone to the carboxylic acid was performed with the aim of improving on the reactivity of the parent, which was first reported decades ago. Over 20 derivatives were prepared, 10 of which e...

Recent years have seen much effort to discover new chemotypes of BRD4 inhibitors. Interestingly, some kinase inhibitors have been demonstrated to be potent bromodomain inhibitors, especially the PLK1 inhibitor BI-2536 and the JAK2 inhibitor TG101209, which can bind to BRD4 with IC50 values of 0....

Identification and characterization of marine natural products with antimicrobial, antioxidant activity with minimal toxicity has received much interest over the past few years. Among, Acropora formosa is one of the unexplored marine organism for the screening of natural products in marine resou...

The phase diagram of urea–4-bromo-2-nitroaniline system was studied which shows a large miscibility gap and the formation of a eutectic and a monotectic where the mole fractions of 4-bromo-2-nitroaniline are 0.899 and 0.020, respectively. The critical temperature is being 61.5 °C above the mon...

2,4-Dinitrodiphenylamine (I), 2-nitro-4-(trifluoromethyl)aniline (II) and 4-bromo-2-nitroaniline (III) have been investigated by DFT and experimental FTIR, Raman and UV–Vis spectroscopies. The gas-phase molecular geometries were consistent with similar compounds already reported in the literatu...

Plant-derived non-essential fatty acids are important dietary nutrients, and some are purported to have chemopreventive properties against various cancers, including that of the prostate. In this study, we determined the ability of seven dietary C-18 fatty acids to cause cytotoxicity and induce ...

Changes in conjugated linoleic acid (CLA) concentration, fatty acid profile and chemical composition of yogurts from cow and sheep milk, produced with traditional methods, were determined during a 14-day storage at 5 °C. When fatty acid (FA) composition of yogurts was expressed as g/100 g of ed...

Lipid accumulation is the hallmark of Non-alcoholic Fatty Liver Disease (NAFLD) and has been suggested to play a role in promoting fatty liver inflammation. Previous findings indicate that during oxidative stress conditions excess cholesterol autoxidizes to oxysterols. To date, the role of oxyst...

Several grams of labelled trans linoleic and linolenic acids with high chemical and isomeric purities (>97%) have been prepared for human metabolism studies. A total of 12.5 g of (9Z,12E)-[1-13C]-octadeca-9,12-dienoic acid and 6.3 g of (9Z,12Z,15E)-[1-13C]-octadeca-9,12,15-trienoic acid were obt...

The fatty acid methyl esters (FAMEs) profiles of fruit peel and pulp of 4 Spanish cultivars of Ziziphus jujuba were studied. The FAMEs profile of the cultivar ‘GAL’ was studied under two farming practices, (i) organic, ‘GAL-E’ and conventional, ‘GAL-T’. Eleven FAMEs were identified, the pr...

Infrared spectra obtained for the title compound, (CH3)2CCH. CH2Br, have revealed the co-existence of two rotational isomeric forms in the fluid phases, the geometrical structures of which cannot be ascertained by use of vibrational spectroscopy alone. The energy ditterence between the two iso...

The molecular structure of 1-bromo-3-methyl-2-butene has been studied at a nozzle-tip temperature of 306 K. The major component of the vapor, if not all, consists of the gauche conformer. Three theoretical models have been used to fit the data. A two-conformer model is found to fit the data slig...

Infrared spectra were obtained for 2-chloro-l-butene and 2-bromo-l-butene that show the presence of trans and gauche rotamers in both compounds. Vibrational assignments were made with the aid of normal coordinate calculations that utilized a thirty-eight parameter valence force field.