A thermostable esterase of Pseudomonas putida MR-2068, which catalyzes the stereoselective hydrolysis of methyl dl-β-acetylthioisobutyrate (dl-ester) to give d-β-acetylthioisobutyrate (DAT) was cloned in Escherichia coli cells. The enzyme was purified to homogeneity by the methods including am...

The resolution of trans-2,2-dichloro-3-methylcyclopropanecarboxylic acid trans-1 was achieved by crystallization of its salts with (+)- and (−)-α-phenylethylamine. The chiral acids were converted into methyl esters 9, which upon reaction with sodium methoxide in methanol underwent a three-carbo...

γ-Coniceine reductase, isolated from leaves and fruits of a number of Conium maculatum cultivars, was NADPH dependent. The hydride ion was transf

The structure of a sooting premixed methane/oxygen flame doped with toluene (C/O = 0.66) was studied by means of sampling and chemical and spectroscopic analysis of gas and condensed phases. It was found that the addition of toluene in small amounts (0.8 mol%) to the methane flame (C/O = 0.6) us...

Solubility of 2-amino-5-methylthiazole in methanol, ethanol, n-propanol, isopropanol, acetone, 2-butanone, acetonitrile, ethyl acetate, toluene, 1,4-dioxane and cyclohexane were determined by using the isothermal saturation method over a temperature range from (278.15 to 313.15) K under atmosphe...

Thirty thiazole compounds bearing chemotherapeutically-active pharmacophores were synthesized and evaluated for their preliminary in vitro antimicrobial and anticancer activities. Nineteen compounds displayed obvious antibacterial potential, with special bactericidal activity against Gram positi...

The synthesized hydrogen bonded charge transfer (CT) complex between 2-amino-4-methylthiazole (AMT) and chloranilic acid (CLA) was characterized using various spectral techniques such as UV–visible, FTIR, 1H NMR, ESI-MS, P-XRD and TG/DTA analysis. The CT complexes act as an intermediate in a va...

Following a study of the effect of benzyl substitution on the rates of nucleophilic dealkylation of phosphotriesters, 2-4 dinitrobenzyl is proposed as a temporary protecting group for 3′-terminal phosphodiester functions in oligonucleotide synthesis.

The putative intermediate bis(1,2,4-triazolide) derivative (5) is used in the stepwise synthesis in solution of the phosphorodithioate analogue (10) of thymidylyl-(3′→5′)-thymidylyl-(3′→5′)-thymidine; the 2,4-dinitrobenzyl (Dnb) group is used to protect phosphorodithioate internucleotide l...

The thermally activated NH→CH tautomerization process in crystals of 2(2,4-dinitrobenzyl) pyridine derivatives was investigated. The results indicate the absence of any trivial molecular structure–reactivity correlation, in contrast to what is found for similar systems in solutions. The absenc...

The Equilibrium constants for imine-enamine and aci-nitro tautomerism of 2-(2,4-dinitrobenzyl)pyridine have been determined as 7.5 × 10−9 and ∼3 × 10−14 respectively.

Photoinduced absorption changes and thermal bleaching of the absorption were measured at different temperatures in 2- and 4-(2,4-dinitrobenzyl)pyridine (α- and γ-DNBP) dispersed in polymer films in order to elucidate the mechanism of the photoinduced intramolecular proton transfer (PIPT) in DN...

The first example of immobilized baker's yeast in alginate fibers with double-layer mediated reduction of ketones is described. The asymmetric reduction of ethyl benzoylformate (EBF) to ethyl (R)-mandelate ((R)-EM) in a continuous process was carried out in a packed bed reactor with Sacchar...

A novel amino salicylato salt, 2-amino-6-methylpyridinium 2-hydroxy-5-sulfonatobenzoate (1), and its Cu(II) complex, 2-ammonio-6-methylpyridinium bis(μ6-5-sulfonatosalicylatoaquacopper(II)) (2), have been synthesized from free ligands, namely 5-sulfosalicylic acid (H3ssa) and 2-amino-6-methylpy...

Cocrystal-salt continuum study is important to pharmaceutical industry, for which the empirical ΔpKa rules are not always applicable and a deep understanding is still required. In this present study, multicomponent crystals of ibuprofen (IBU) were screened and investigated based on pyridine-con...

Single crystal growth of two inorganic-organic compounds, Bis[2-methylpyridine tetrachlorozincate] (MPCZ) and Bis[2-amino-5-chloropyridine tetrachlorozincate] (ACPCZ) has been achieved by two different methods i.e. Gel growth and Solution growth through slow cooling process. Due to change in org...

The Fourier transform Raman (3500–50 cm−1) and Fourier transform infrared (4000–400 cm−1) spectra of 2-amino-5-methylpyridine and 2-amino-6-methylpyridine have been measured in solid phase. The Fourier transform gas phase infrared spectra of 2-amino-5-methylpyridine and 2-amino-6-methylpyridin...

The solid-state thermolysis (420–450 °С) of the new heterometallic coordination polymer [Li2Co2(Piv)6(μ-L)2]n (1, Piv is the anion of pivalic acid, L is 2-amino-5-methylpyridine) followed by annealing of the decomposition products at 500 °С was shown to afford LiCoO2 in quantitative yield....

The crystal structures of 2-amino-4-methyl-3-nitropyridine (I), 2-amino-4-methyl-3,5-dinitropyridine (II) and 2-amino-4-methyl-5-nitropyridine (III) have been determined. The compounds crystallize in the monoclinic P21/n, triclinic P-1 and monoclinic C2/c space groups, respectively. These struct...

Three isomorphic, Mg, Mn and Zn phthalocyaninato complexes monoaxially ligated by 2-amino-3-picoline (2A3P) are obtained. They crystallise with 2A3P molecule as solvent molecule in the centrosymmetric space group P21/c of monoclinic system. The central M(II) atom in these complexes, M(II)Pc(2A3P...