A complexation of non-fluorescent phenformin hydrochloride (PFH) with cucurbit [7]uril (CB [7]) in aqueous solution was investigated using the fluorescent probe of palmatine (PAL) coupled with CB [7]. The fluorescent probe of CB [7]–PAL exhibited strong fluorescence in aqueous solution, which w...

Adducts to N-terminal valines in Hb have been shown useful as biomarkers of exposure to electrophilic compounds. Adducts from many compounds have earlier been measured with a modified Edman degradation method using a GC–MS/MS method. A recently developed method, the adduct FIRE procedure™, adop...

Aryl diketoacids (ADK) and their bioisosteres are among the most promising HIV-1 integrase (IN) inhibitors. Previously, we designed a series of ADK dimers as a new class of IN inhibitors that were hypothesized to target two divalent metal ions on the active site of IN. Herein we present a furthe...

Focal thrombus formation and vasoconstriction serve to defend vessels when vascular damage occurs, but may be detrimental when an atherosclerotic plaque is disrupted. Recently, the identification of the platelet thrombin receptor opened a new area in the development of agents that may selectivel...

A series of β-substituted enaminones were prepared through the one-pot reaction of β-dicarbonyl compounds with various amines in the presence of silica ferric hydrogensulfate under solvent free conditions at room temperature. The reactions proceed smoothly in excellent yield, high chemoselecti...

Copper oxide nanoparticles and copper sulfate are established contaminants of water and soil. Metaphire posthuma is a common variety of earthworm distributed in moist soil of Indian subcontinent. Comparative toxicity of copper nanoparticles and copper sulfate were investigated with reference to ...

Copper sulfate (CuSO4) is a ubiquitous component in natural minerals and industrial dusts. However, CuSO4 has been believed usually that it has adverse effect on elemental mercury (Hg0) removal from flue gas. Here, we offered a new insight into the effect of crystal water in copper sulfate on Hg...

Organic acids released during the decomposition of organic soil amendments have been used in crop fields as benign chemicals to control phytopathogens. However, the use of organic acids against root-knot nematodes (RKNs, Meloidogyne spp.) has not been recommended in practice, owing to their shor...

The selective recovery of copper(II) from Cu-Zn sulfate solutions using solvent extraction and N,N-dialkyl-N′-hydroxypyridine-2-carboximidamides as extractants was investigated. Three compounds were synthesized and their extractability toward copper(II) and zinc(II) was studied. The influence o...

The single-stage biological sulfate reduction process for treatment of heavy metal laden wastewater is a promising treatment method, but the formation of metal precipitates has been suggested to be inhibitory to the activity of sulfate reducers. The present study examined the impact of copper (C...

The Peterson olefination reaction of terephthalaldehyde with tris(trimethylsilyl)methyllithium, (Me3Si)3CLi, in Et2O gives disubstituted vinylbis(silane) 1 which reacts with MCPBA in CH2Cl2 at r.t. to afford mixture of mono and disubstituted epoxybis(silanes) 3 and 2. Vinylbis(silane) 1 can be c...

Methyl 2-diazo-3-hydroxy-6,6-dimethyl-4-heptynoate was prepared by treating 4,4-dimethyl-2-pentyn-1-al with methyl diazoacetate at room temperature in the absence of catalysts. In the case of related aldehydes, RCCCHO (R = n-Bu, Me3Si, Et3Si, Et3Ge), this unusual reaction is partially or compl...

Characterization, thermal stability and thermal decomposition of alkali metal mandelates, M(C6H5CH(OH)CO2)nH2O (where M represents Na, K, Rb and Cs and n = 0.3 (Na), 0.6 (K), 2 (Rb) and 1 (Cs)) were investigated employing simultaneous thermogravimetry and differential scanning calorimetry (TG-DS...

Mandelate racemase (MR) catalyzes the interconversion of the enantiomers of mandelate using a two-base mechanism with Lys 166 acting as the Brønsted base to abstract the α-proton from (S)-mandelate. The resulting intermediate is subsequently re-protonated by the conjugate acid of His 297 to yie...

5,6-Dihydrobenz[c]acridines were synthesized by the reaction of 1-chloro-3,4-dihydro-2-naphthaldehyde with aromatic amines under three different conditions:a.Thermolysis of 1-chlorovinyl-(N-aryl)imines prepared from 1-chloro-3,4-dihydro-2-naphthaldehyde.b.Acid catalyzed cyclization of 1-(N-aryl)...

A facile synthesis of 2-difluoromethylated quinolines via DBU-promoted cascade Michael addition/cyclization between functionalized 2-aminobenzonitriles and methyl 4,4-difluorobut-2-ynoate has been developed. Various highly functionalized quinolines were assembled in moderate to good yields under...

Rhodococcus sp. AJ270 is a useful biocatalyst for the synthesis of some enantiopure S-(+)-2-aryl-3-methylbutyric acids and R-(+)-2-aryl-3-methylbutyramides from the hydrolysis of 2-aryl-3-methylbutyronitriles under mild conditions. The nitrile-hydrolyzing enzymes involved in this novel microorga...

A general chiral building block containing the 1R,2R-trans-diol moiety was constructed utilizing the stereoselective Shi-epoxidation reaction on a tetralone scaffold assembled by a Negishi cross-coupling on N,N-diethylbenzamide. Further elaboration of this chiral building block into polycyclic a...

The reaction of organolithium and Grignard reagents with pentacarbonyl[(ethoxy)(2-phenylethenyl)carbene]chromium(0) gave, after the quenching of the initially formed product of the 1,4-addition, different products depending on the organometallic and quenching reagents used. The addition of organ...

Rhodotorula mucilaginosa produces the siderophore rhodotorulic acid (RA) when grown in iron-limited conditions. R. mucilaginosa grew at rates between 0.10 and 0.19 h−1 in iron-restricted conditions, depending on the carbon source, and at 0.23 h−1 in iron-sufficient conditions. In bioreactors ino...