A novel method for the simultaneous high-performance liquid chromatographic determination of nortriptyline hydrochloride and fluphenazine hydrochloride was developed and validated. Fluvastatin sodium was used as internal standard. The determination was performed on a Hypersil Gold C8 column (250...

Dipeptidyl peptidase IV (DPP-IV) inhibitors are expected to become a useful new class of anti-diabetic agent. The aim of the present study is to characterize the in vitro and in vivo profile of E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate, w...

A series of heteroleptic copper(II) complexes of the type [CuL1–4(diimine)](ClO4)2 (1–8) [L1–4 = 2-((2-(piperazin-1-yl)ethylimino)methyl)-4-substituted phenols, and diimine = 2,2′-bipyridyl (bpy) or 1,10-phenanthroline (phen)], have been synthesized and characterized by spectroscopic methods...

A short and stereoselective route for the synthesis of 2-oxopiperazines is presented starting from different naturally abundant α-amino acids. The key synthetic steps involved amide coupling, Wittig reaction, HWE olefination, aza-Michael reaction, iodocyclization. This new pathway involving fir...

A new general method for the synthesis of enols of cyclic 3-alkynyl-substituted 1,2-diketones is developed. Sonogashira cross-coupling of silyl enolates of cyclic 3-bromo-cyclopentane- and 3-bromo-cyclohexane-1,2-diones with variety of substituted acetylenes afforded enols of cyclic 3-alkynyl-1,...

Negishi cross-coupling of the silyl-protected 3-bromoenol of 1,2-cyclopentanedione with primary and secondary alkylzinc reagents using Pd-catalysts affords 3-alkyl substituted 1,2-cyclopentanediones in good yield. The method was applied to obtain 3-methylalkoxycarbonyl- and 3(2-Boc-aminoethyl)-a...

The increasing number of deaths caused by drug poisoning indicates that a rapid and accurate method to identify the type of drugs is critically needed to provide a real-time and effective treatment for poisoned patients. In this report, a surface-enhanced Raman scattering (SERS) analysis method ...

The preparation of N-doped carbon dots (N-CDs) was facile and efficient by the hydrothermal method, using diethylenetriamine (DETA) and citric acid (CA) as nitrogen source and carbon source, respectively. The fluorescence of N-CDs was effectively quenched by Fe3+. Upon addition of hydroxylamine ...

Polyaniline hydrochloride/cerium oxide nanocomposite has been prepared by in-situ polymerization technique. Field emission scanning electron microscopy confirms the morphology of the nanocomposite was spherical with diameter around 80nm. The X-ray diffraction, optical spectra, thermal analysis a...

Oxyntomodulin (OXM), glucagon, and glucagon-like peptide-1 (GLP-1), peptide hormones derived from the glucagon gene, play an important role in glucose homeostasis. The insulinotropic action of these three homologous peptides has been well documented in monogastric animals. However, information o...

Some new S-dialkylarsenic compounds, S-dialkylarsino-3-mercapto-1,2-propanediol (3a–3d) and their derivatives (4a,4b), have been synthesized. They were screened at the National Cancer Institute (NCI) for their anticancer activity against a panel of about 60 human tumor cell lines. Most of them ...

This paper deals with multi-objective optimization of continuous bio-dissimilation process of glycerol to 1, 3-propanediol. In order to maximize the production rate of 1, 3-propanediol, maximize the conversion rate of glycerol to 1, 3-propanediol, maximize the conversion rate of glycerol, and mi...

The objective of the presented work is to demonstrate the metabolism of 1,2 propandiol by Lactobacillus reuteri and to elucidate the metabolites produced during the process. This Metabolic pathway is crucial for biotechnological applications using L. reuteri in bioconversion of glycerol to indus...

Lactobacillus reuteri metabolizes glycerol through propanediol-utilization (Pdu) pathway to 1,3-propanediol (1,3-PD) via 3-hydroxypropionaldehyde (3-HPA) as intermediate. In the resting cells, the oxidized co-factor obtained in the reaction is regenerated by simultaneous oxidation of 3-HPA to 3-...

A novel microbial method of synthesizing (S)-1-phenyl-1,3-propanediol [(S)-PPD] was developed in this study. Our laboratory stock cultures were screened for microorganisms that stereospecifically produced (S)-PPD from 3-hydroxy-1-phenylpropane-1-one (HPPO) using an intact cell system. Of the 828...

The probiotic bacterium, Lactobacillus reuteri, possesses a unique pathway for metabolizing glycerol into 3-hydroxypropionic acid (3-HP) and 1,3-propanediol (1,3-PD), which are two important platform chemicals. In this work, a potent L. reuteri strain, designated as FXZ014, was isolated and iden...

In this work, aqueous 2‑amino‑1, 3‑propanediol solution (serinol) was investigated as a potential solvent for CO2 capture from different gas streams. Prior to CO2 solubility experiments, a qualitative prediction technique was performed on serinol to ensure its potentiality as a CO2 capture solve...

Due to the relevant role that polyols play either as solvents or additives in many industries thermodynamic properties of aqueous mixtures of these compounds have been largely studied. In this work we aim to study the effect of adding a small amount of 3-butoxypropan-1-amine on the volumetric pr...

Using mathematical model and computer simulation to predict biological processes and optimize the target production is an important strategy for optimizing fermentation process. However, the inherent uncertainty of the kinetic model severely limits the predictive capability. In this study, optim...

Three alkaloids, aknadinine, 1-nitroaknadinine and sinococuline, isolated from Stephania sutchuenensis were studied for their effects on a fibroblast cell line, eight tumour cell lines and a rat alveolar macrophage culture. Sinococuline is an effective tumour cell growth inhibitor whereas the to...