Publisher SummaryThis chapter provides an overview of captopril. It discusses the name, formula, molecular weight, and appearance, color, and odor of captopril. Various physical properties are discussed— spectral properties, solid state properties, and solution data. Several analytical tests an...

A sensitive method for the determination of captopril in blood and urine by gas chromatography—mass spectrometry is described. In order to prevent oxidative degradation of captopril, its sulph-hydryl group was immediately protected by treatment with N-ethylmaleimide (NEM), and the resulting NEM...

A gas chromatographicmass spectrometric method is described for the simultaneous measurement of the novel anti-hypertensive drug captopril, and the following metabolites: captopril disulfide dimer, S-methyl captopril, and S-methyl captopril sulfone. With this method all derivatives can be chro...

A series of novel heterocyclic 4-substituted pyridine-3-sulfonamides 2–13, 15–20 have been synthesized and investigated as inhibitors of four isoforms of zinc enzyme carbonic anhydrase (CA.EC 4.2.1.1), that is the cytosolic CA I and II, and tumor-associated isozymes CA IX and XII. Against the ...

A new ionic liquid, tributyloctylphosphonium benzotriazolate ([P4448][BTA]), was synthesized, and the density, viscosity, and electrical conductivity of [P4448][BTA] were measured at atmospheric pressure. As temperature increased, the density and viscosity decreased, while the electrical conduct...

A novel synthesis of 1-substituted tetrahydro-1H-3-benzazepines 4 is described. Starting with (2-bromophenyl)acetaldehyde acetal 5, the nitrostyrene 9 was prepared in three steps allowing the addition of various nucleophiles to yield the nitroacetals 10. The one-pot Zn/HCl reductive cyclization ...

Herein we report a facile organocatalytic asymmetric direct cross-aldol reaction of 2-chloroethoxy acetaldehyde with aromatic aldehydes using (S)-(−)-α,α-diphenyl-2-pyrrolidinemethanol as an organocatalyst to afford anti-2-(2-chloroethoxy)-1-arylpropane-1,3-diols with excellent enantioselectiv...

Direct aerobic oxidative cross-dehydrogenative coupling of aryl acetaldehydes at C-3 position of imidazoheterocycles via copper catalyzed reaction resulted in the synthesis of dicarbonylated imidazoheterocycles in 55–85% yields. The methodology provides a straightforward, high yielding and one-...

A novel whole cell system based on recombinantly expressed 4-oxalocrotonate tautomerase (4-OT) was developed and shown to be an effective biocatalyst for the asymmetric Michael addition of acetaldehyde to β-nitrostyrenes. Optimal ratio of substrates (2 mM β-nitrostyrenes and 20 mM acetaldehyde...

A series of novel thiazolidin-4-ones bearing a lipophilic adamantyl substituent at position 2 or 3 were synthesized. A majority of them showed a modest anti-HIV-1 activity, whereas 2-adamantan-1-yl-3-(4,6-dimethylpyrimidin-2-yl)-thiazolidin-4-one (8) was endowed with a remarkable antiviral poten...

Asymmetric aldol reactions of aliphatic ketones or aldehydes with aromatic aldehydes or isatins were catalyzed by a very simple and flexible N-(2,6-difluorophenyl)-l-valinamide. Interestingly, stereochemical course of the reaction of hydroxyacetones or α-branched aliphatic aldehydes as aldol do...

Previous reports suggest that γ-aminobutyric acid type A (GABAA) receptors containing α1 subunits may play a pivotal role in mediating the discriminative stimulus effects of benzodiazepines (BZs). L-838,417 (7-tert-Butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4...

Double deprotonations of 1,4-dibromo-2,5-difluorobenzene with LDA (2 equiv., T

The absolute molecular structure of air stable n-type semiconducting material 2,5-difluoro-1,4-phenylene-3,3′-bis{2-[(4-trifluoromethyl)phenyl]acrylonitrile} was determined by using twin crystal treatment X-ray diffraction analysis. The compound was readily dimerized in solution via irradiating...

The recovery and separation of vanadium and chromium from vanadium-containing chromate solution are necessary and valuable for the comprehensive utilization and environmental protection of V-Ti-bearing magnetite ore. In this work, a tetragonal ZrO2 adsorbent was used for harmless treatment and r...

As a member of the family of so-called MXenes, two-dimensional vanadium carbide (V2CTx, denoted as V-MXene) used in electrocatalytic hydrogen evolution reaction (HER) is still in the stage of theoretical study without significant experimental exploration. Here, we present the theoretical and exp...

Reducing starch digestibility can significantly benefit efforts to combat obesity and associated chronic diseases. Polymeric proanthocyanidins (PA) form complexes with starch via unknown mechanisms, resulting in dramatically decreased starch digestibility. We hypothesized that V-type complexes a...

Model-Based System engineering (MBSE) promotes Verification and Validation (V&V) as crucial activities to demonstrate, during the system design stage and based on models, that a system meets requirements defined by stakeholders and that it fulfills its intended purpose. Model V&V activities are ...

The enhancement in the heat transfer (Nu), friction factor (f) and thermal performance (η) for a forced circulation V trough solar collector fitted with helix twisted tape (HTT), helix with square cut twisted tape (HSCTT) and helix with V cut twisted tape (HVCTT) with two different twist ratios...

In order to efficiently extract vanadium and remove phosphorus from acidic leaching solutions of vanadium-bearing converter slag, thermodynamic equilibrium diagrams of V-H2O and V-P-H2O systems were analyzed to understand the transformation rules of the single-core ion, isopolyacid ion, and hete...