A series of novel tetrahydropyrimidines was synthesized and examined for M1 muscarinic receptor activity. 1,4,5,6-Tetrahydro-5-methoxycarbonyl-pyrimidine hydrobromide (1a; CDD-0034-C) displayed a high affinity for muscarinic receptors in rat brain and stimulated PI metabolism in rat hippocampus....

The complexes RuCl2(L1)(arene) (3–4) (L1=HCNCH2CH2NR, R=Et, arene=p-MeC6H4CHMe2 or C6Me6) and RuCl2(L2)(arene) (5–6) (L2=HCNCH2CH2CH2NR, R=Me, Ph, CH2Ph, p-MeC6H4) have been synthesized by reaction of [RuCl2(arene)]2 with 1-alkyl-2-imidazoline (1) or 1-alkyl-1,4,5,6-tetrahydropyrimidine (2...

A series of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives were prepared to evaluate their ability of inhibiting neuraminidase (NA) of influenza A virus. All the compounds were synthesized in good yields starting from aldehyde by using a suitable synthetic strategy, which showed mo...

At 25°C, and under 1 to 7 bar nitrogen pressure, the isomerization of 4-methyl-1-pentene catalyzed in benzene by CoHN2(PPh3)3 involves two active species: HCoN2(S1)(PPh3)2 and HCo(S1)(PPh3)3, respectively, in greater quantities at higher (P(N2) > 7 bars) and small quantities at P(N2)  0 nitro...

Hydrogenolysis of cyclohexane has been explored over supported Ir catalysts. The kinetic data are combined with modeling results to assess the structural requirements and the nature of catalytically relevant surface intermediates for endocyclic C–C bond cleavage. The turnover frequency (TOF) fo...

Experimental data and modelling results of the main products and intermediates from a fuel-rich sooting premixed cyclohexane flame were presented in this work. Model predictions well agree with experimental data both in sooting and non-sooting flames. Major and minor species are properly predict...

Ignition delay times of cyclohexane–oxygen–argon and cyclopentane–oxygen–argon mixtures have been measured in a shock tube, the onset of ignition being detected by OH radical emission. Mixtures contained 0.5 or 1% of hydrocarbon for values of the equivalence ratio ranging from 0.5 to 2. Refl...

Extraction followed by heteroazeotropic distillation is considered to be a potentially energy-saving method for purifying acrylic acid. Based on our previous work, cyclopentyl methyl ether is an excellent solvent that can be used as extractive an agent as well as an entrainer. In this work, liqu...

Laminar flame speeds of cyclopentane/air and cyclohexane/air mixtures were determined at equivalence ratios of 0.7–1.6, initial pressures of 1–5 atm, and initial temperatures of 353–453 K using the spherically propagating flame method. Four recently published models of cyclopentane and cycloh...

The commercial dichloro(2-pyridinecarboxylato)gold(III) complex (1), anchored on different carbon materials, is reported for the first time as a catalyst in the cyclohexane hydrocarboxylation to cyclohexanecarboxylic acid. The reaction was carried out in the presence of CO and water, peroxodisul...

An HPLC separation of a complex mixture containing 13 urinary anabolics and corticoids, and boldenone and bolasterone (synthetic anabolics) has been carried out. The applied optimization method involved the use of binary, ternary and quaternary mobile phases containing acetonitrile, methanol or ...

An oxygen analog of the antineoplastic anthraquinone, 1,4-dihydroxy-5,8-bis[[2-(2-hydroxyethyl)amino]ethyl]arnino - 9,10 -an-thracenedione, was synthesized. This compound, 1,4-dihydroxy-5,8-bis[[2-(2-hydroxyethoxy)ethyl]amino]-9,10-anthracenedione, was found to be inactive against P-388 lymphocy...

A photoluminescent terbium (Tb) complex involving a novel benzoic-acid compound with a unique coordinated structure, namely 1,4-bis(carbonylmethyl)terephthalate (BCMT), has been designed and synthesized. The new coordinate structure and energy-transfer mechanism between the ligand and Tb(III) io...

The convenient synthesis of new aminomethylphosphinic acids and their derivatives containing N-alkyl 4-hydroxypiperidines moieties was developed. The addition of bis(trimethylsiloxy)phosphine to N-alkyl 4-piperidones proceeds under mild conditions to give PH-phosphinates as key compounds for pre...

Diethylphenylphosphine reacts with p-chloranil at a carbon atom and forms a trichloroquinone-C-phosphonium chloride. Triphenylphosphine reacts with chloranil at an oxygen atom and forms an O-phosphonium-phenoxide dipolar-ion. Possible reasons for this difference are discussed. The trichloroquino...

Dimethylbis(diethylphenylphosphine)palladium(II) complex was found to undergo a facile trans-cis isomerization reaction in tetrahydrofuran containing methylmagnesium compounds such as Me2Mg and MeMgBr. Kinetic and isotopic studies on the isomerization process suggest the occurrence of methylmagn...

Purified mouse liver cytochrome P-450 reconstituted with purified NADPH-cytochrome P-450 reductase and phosphatidylcholine metabolized diethylphenylphosphine to diethylphenylphosphine oxide. NADPH was required for the reaction and the amount of oxide formed was time and cytochrome P-450 dependen...

FT-IR, FT-Raman and surface-enhanced Raman scattering spectra of 5-ethylsulphonyl-2-(o-chlorobenzyl)benzoxazole were recorded and analyzed. The vibrational wavenumbers were examined theoretically using the Gaussian09 set of quantum chemistry codes, and the normal modes were assigned by potential...

A specific method is described for the quantitative analysis of deuterated and non-deuterated phenylalanine and tyrosine in human plasma by gas chromatography-mass spectrometry using selective ion monitoring. From the several derivatives investigated, the N- or N,O-trifluoroacetyl methyl esters ...

The reaction of 6-chloro-1-hexynylphosphonate with primary and secondary amines afforded exclusively 2-aminocyclohexenylphosphonates in 62–85% isolated yields. In contrast, reaction of various amines with isobutyl 7-chlorohept-2-ynoate in acetonitrile at 70 °C gave (E)-sec-butyl 2-(1-alkylpipe...