We characterize the structure of two Cu(II) complexes of 7-hydroxycoumarins in organic solvents. The solvents are, dimethyl sulfoxide and dimethylformamide. X-ray absorption spectroscopy together with density functional theory calculations are employed to identify the structural changes induced ...

Activation of β1-adrenoceptor stimulates myocardial membrane destabilization in isoproterenol induced rats. Male albino Wistar rats were pre and co-treated with 7-hydroxycoumarin (16 mg/kg body weight) daily for 8 days. Myocardial infarction was induced into rats by the subcutaneous administrat...

The standard (p° = 0.1 MPa) molar energy of combustion in oxygen, at T = 298.15 K, of 7-hydroxycoumarin was measured by static bomb calorimetry. The value of the standard molar enthalpy of sublimation was obtained by Calvet microcalorimetry and corrected to T = 298.15 K. Combining these results...

A 60Co source generating gamma radiations was used to graft polyethylene (PE) films with acryloyl chloride (AC). Different doses of radiations (2, 4, 6 and 8 kGy) were employed in order to obtain polymers with different amount of grafted ramifications. Furthermore, the desired photoluminescent p...

In the present study, we assessed whether 7-hydroxycoumarin (umbelliferone), 7-hydroxy-4-methylcoumarin, and their acetylated analogs modulate some of the effector functions of human neutrophils and display antioxidant activity. These compounds decreased the ability of neutrophils to generate su...

Methyl glyoxal (MG), a major precursor of advanced glycation end-products, has been identified as significant in the progression of several diseases including aging, diabetes and neurodegenerative diseases as well as causing hepatic damages. 7-hydroxycoumarin (7-HC), a natural-occurring derivati...

A novel compound, Cou-platin, composed of 7-hydroxycoumarin and a platinum(IV) moiety derived from cisplatin was designed and synthesized. Significantly, Cou-platin exhibited more potent in vitro antitumor activity against all tested cancer cell lines than that of cisplatin, which was mainly att...

Two new copper(II) complexes based on 6/8-acetyl-3,8/6-dibromo-7-hydroxy-4-methylcoumarin have been synthesized and structurally characterized. The electrochemical synthesis has been applied to enforce the complexation reaction. Characterization of non-crystalline product have been performed usi...

A series of bi-functional 7-hydroxycoumarin platinum(IV) complexes were synthesized, characterized, and evaluated for antitumor activities. The 7-hydroxycoumarin platinum(IV) complexes display moderate to effective antitumor activities toward the tested cell lines and show much potential in over...

Compared with coumarin, 7-hydroxycoumarin could serve as a better hit for developing CYP2A6 inhibitors. In this study, a series of 7-hydroxycoumarin and its structural analogues were collected to study their structure-activity relationship (SAR) and isoform selectivity for inhibiting CYP2A6. All...

Acid dissociation constants of some β-keto esters, viz ethyl acetoacetate, ethyl α-phenyl acetoacetate, ethyl α-γ-diphenyl acetoacetate, ethyl α-(phenyl)phenylpropioloylacetate, ethyl α-(α-napththyl) phenylpropioloylacetate, have been determined potentiometrically in 75 vol% dioxane-water...

By the conventional methods of gas liquid chromatography (GLC) as well as mass spectrometry, 3β,7α-dihydroxychol-5-en-24-oic acid (Δ5-acid), a key intermediate of chenodeoxycholic acid biogenesis and its metabolic by-product, 3α,7α-dihydroxychol-4-en-24-oic acid (Δ4-acid) have not yet been...

Salicylanilides have proved their activity against tuberculosis (TB). One weak electron-withdrawing substituent is favored at the salicylic part, specially Cl or Br atoms at positions 4 or 5. On the other hand, the antimycobacterial activity of salicylanilides is negatively affected when a stron...

Twenty more aromatic amines are determined by the diazotization and coupling spectrophotometric technique, with 8-amino-1-hydroxynaphthalene-3,6-disulphonic acid (H-acid) and N-(1-naphthy)ethylenediamine (N-na) as coupling agents. The following are determined by both methods: 2,4-diaminotoluene,...

A very simple, sensitive, fairly selective and rapid spectrophotometric method for the determination of trace amounts of nitrite has been described. This method is based on the diazotized intramolecular coupling of electrophilic diazonium cation with the phenolic group of 4-amino-5-hydroxynaphth...

Hybrid halochromic sensor coatings were realized immobilizing Nitrazine Yellow (NY) onto cotton fabrics via the epoxy group of 3-glycidoxypropyltrimethoxysilane (GPTMS) silica precursor in acidic condition. Boron trifluoride diethyl etherate (BF3OEt2) in a various percentage range (1–10%, w/w G...

Effects of the addition of various additives in the working electrolyte on the selectivity of capillary electrophoretic separation of naphthalenesulphonic acids used as intermediates in the production of synthetic dyes were investigated. Cyclodextrins form inclusion complexes with various compou...

The mechanism of high-energy radiation induced degradation of H-acid (4-amino-5-hydroxynaphthalene-2,7-disulphonic acid, (I)) and its derivative, 4-hydroxynaphthalene-2,7-disulphonic acid (II) (central parts of a large number of azo dyes), was investigated in aqueous solutions. These compounds c...

Here, we reported the regioselective formation of poly(amino naphthalene disulfonic acid) (PANDA) nanoparticles by a template-free polymerization process in an aqueous alkaline medium. The NMR, FT-IR, UV–vis, gel permeation chromatography (GPC), thermogravimetry (TG), differential scanning calo...

JAKs inhibitors were widely applied in the treatment of immunodeficiency diseases, inflammation and cancers. We designed and synthesized a novel series of 4-aminopyrazole derivatives, which showed inhibitory potency against various JAKs. The in vitro protein kinase inhibition experiment indicate...