Copper ion catalyzed carbon–carbon bond forming reaction of N-acyliminium ions with diaryl malonates was achieved with high enantioselectivity. The key intermediates in the method were 2-methoxy-3,4-didehydropiperidines, which were easily prepared through electrochemical oxidation of 1-(p-metho...

A series of simple and new C2-symmetric diphenylmethylidene malonate-type bis(oxazoline) ligands were synthesized and applied to the Friedel–Crafts reaction and allylic alkylation. The Cu(II) complex of ligand 4b bearing the benzyl group afforded good to excellent enantioselectivity for the F–...

An organocatalytic enantioselective synthesis of α-methylene-γ-lactams has been developed. The reaction between protected 2-aminomalonates and Morita–Baylis–Hillman carbonates is catalyzed by chiral Lewis bases to afford the corresponding lactams in excellent yields and moderate to good enan...

An organocatalyzed direct Michael addition of unsubstituted/substituted malonates, acetoacetate, or acetylacetones to conjugated nitrodienes using a cinchona alkaloid-based thiourea catalyst is disclosed. The addition products were formed in high yields and regioselectivity. The enantioselectivi...

The asymmetric Michael addition of diethyl malonate and α-substituted diethyl malonates to aromatic nitroalkenes was carried out under mild reaction conditions in a solid–liquid phase transfer reaction in the presence of α-d-glucopyranoside- and α-d-mannopyranoside-based crown ethers as the ...

The crystal structures of four derivatives of diethyl 2-(((aryl)amino)methylene)malonate (DAM) have been studied by single crystal X-ray diffraction. The molecular structures of all the four derivatives were found to be in co-planar conformation. The detailed analysis of molecular conformation i...

Oxone mediated reaction of imidazo[2,1-b]thiazole, imidazo[1,2-a]pyridine and 1H-pyrazole derivatives with diaryl diselenides is presented here. The methodology represents an efficient and simple protocol for carrying out the selective synthesis of 5-arylselanyl-imidazo[2,1-b]thiazoles, 3-arylse...

Based on our earlier studies of structure activity relationships on 4-substituted piperazine derivatives, in this work we synthesized a novel set of long-chain arylpiperazines with the purpose of elucidating if some structural modifications in the terminal fragment could affect the binding affin...

The complex LPdCl2 (L=(4-ethoxyphenyl)[(2-amino-5-methyl)phenyl] telluride) was prepared by reaction of the ligand with Li2PdCl4 in methanol solution. Red prismatic crystals (LPdCl2·DMSO·H2O) suitable for X-ray analysis were obtained by slow evaporation from DMSO–H2O mixed solvent. This is th...

The reductive coupling of cyclic imides and ω-amidoesters with benzophenones by Zn-TiCl4 in THF and subsequent acid-catalyzed dehydration gave 5-diarylmethylene-1,5-dihydropyrrol-2-ones A, 6-diarylmethyl-2-pyridones B, and ω-(diarylmethylene)lactams C. In a similar manner, 3-((benzyloxy)carbon...

In the search of compounds exhibiting anticancer activity, 37 derivatives of 2-pyrazolinyl-1-carbothioamide were designed and synthesized. Clonogenic cell survival assays were adapted to measure the cytotoxicities of the synthetic derivatives against HCT116 human colon cancer cell lines. Half-ma...

Novel C-nucleosides (2′R,4′S)-and (2′S,4′R)-2-[4-(hydroxymethyl)-1,3-dioxolan-2-yl]-1,3-thiazole-4-carboxamide have been synthesized from stereoselectively induced condensation of optically active triols (S or R) with a 1,3-thiazole-4-carboxamide derivative.

Novel acrylic acid ethyl ester derivatives were synthesized and evaluated as potential agents against Mycobacterium species. A versatile and efficient copper-catalyzed coupling process was developed and used to prepare a library of substituted acrylic acid ethyl ester analogs. Minimum inhibitory...

Hexanedioic acid bis-(2-thiophen-3-yl-ethyl) ester (HABTE) was synthesized via the reaction of 3-thiophene ethanol with adipoyl chloride. Resulting monomer was electrochemically homopolymerized in the presence of tetrabutylammonium tetrafluoroborate as the supporting electrolyte, in acetonitrile...

Terepthalic acid bis-(2-thiophen-3-yl-ethyl)ester (TATE) was synthesized through the reaction of 2-thiophen-3-yl-ethanol and terepthaloyl chloride. Homopolymer of TATE was synthesized via potentiostatic and potentiodynamic methods by using tetrabutylammonium tetrafluoroborate (TBAFB) as the supp...

Octanoic acid 2-thiophen-3-yl-ethyl ester was synthesized via the reaction of 3-thiophene ethanol with octanoyl chloride. The resulting monomer was electrochemically homopolymerized in the presence of tetrabutylammonium tetrafluoroborate as the supporting electrolyte, in the acetonitrile/borontr...

The homopolymer and copolymer of succinic acid bis-(2-thiophen-3-yl-ethyl)ester with thiophene were achieved via constant potential electrolysis in the presence of tetrabutylammonium tetrafluoroborate as the supporting electrolyte, and acetonitrile/borontrifluoride ethylether (ACN/BFEE) (10:2 v/...

Organophosphorus esters (OPEs), as one kind of emerging and toxic contaminant are ubiquitous in various environments. This study investigated the degradation of tris(2-chloroethyl) phosphate (TCEP) as a category OPEs by pyrite (FeS2)-activated persulfate (PS). The result shows that near-100% deg...

Tris (2-chloroethyl) phosphate (TCEP) is a typical phosphate flame retardant. Its potential adverse health effects have recently aroused concern. We investigated the seasonal variations of TCEP concentrations in the raw, finished and tap water samples from two drinking water treatment plants (DW...

Erionite was synthesized under hydrothermal and static conditions and was characterized by Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM) and BET surface area measurement. The dynamic adsorption experiments were carried out on Temperature programed desorption ...