Microtubule targeting agents represent a very active arena in the development of anticancer agents. In particular, compounds binding at the colchicine site in tubulin are being deeply studied, and the structural information recently available on this binding site allows structure-directed design...

An efficient protocol for dealkylation of aryl alkyl ethers under the catalysis of inexpensive and easily reusable Cu2O has been described. The phenol products were obtained in high yields, and a range of functional groups were well tolerated. The choice of solvent is critical to the catalysis, ...

Hyaluronic acid (HA) cross-linked with 1,4-butanediol diglycidyl ether (BDDE) are hydrogels with many biomedical applications. Degree of substitution, cross-linking and substitution position of the cross-linker might influence the properties of the hydrogels. We showed earlier that the most comm...

Polyimides are high performance polymeric materials with excellent physical, thermal and mechanical properties, but its application is limited due to low processability and poor solubility. In order to improve processability and solubility without sacrificing thermal stability, flexible linkages...

An unprecedented organocatalytic asymmetric Michael/Hemiketalization/retro-aldol cascade sequence catalyzed by bifunctional amino-squaramides is described. The corresponding adducts were generally obtained in high yields (up to 97%) with moderate diastereo- (up to 79:21 dr) and good enantioselec...

The epidermal growth factor receptor (EGFR/c-ErbB1/HER1) is overexpressed in many cancers including breast, ovarian, endometrial, and non-small cell lung cancer. An EGFR specific imaging agent could facilitate clinical evaluation of primary tumors and/or metastases. To achieve this goal we desig...

Aurantiochytrium sp. is a heterotrophic microorganism that accumulates high amounts of fatty acids (FAs), including odd-chain FAs and an essential FA, docosahexaenoic acid (DHA). Since complex nutrient sources such as tryptone and yeast extract are conventionally utilized in the growth medium fo...

A simple and facile synthesis of 5-aryl-5,11-dihydro-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6-trione derivatives was accomplished by the one-pot condensation of aromatic aldehydes, 1,3-indandione and 6-amino uracil under solvent-free conditions in the presence of the catalyst, β-cycl...

A new series of 1,3-disulfoimidazolium transition metal chloride systems: [Dsim]2[ZnCl4], [Dsim][FeCl4] and [Dsim]2[NiCl4] were synthesized as Brönsted–Lewis acidic solid material and characterized via NMR, FT-IR, Raman, TGA, SEM, EDX, Powder XRD, UV–visible, ICP-OES and elemental analysis. Se...

Five perylene acid dyes were synthesized to manufacture water-based inks for the high-speed ink jet printing process, including digital textile printing. All the synthesized perylene dyes exhibited superior stability and optical properties compared to a commercially used azo dye. Their water sol...

In the present study, a new low-viscous sulfonic acid-functionalized ionic liquid (SAIL) viz. 4,4′-trimethylene-N,N′-sulfonic acid-dipiperidinium chloride was synthesized and characterized by FTIR, 1D and 2D NMR, and Mass spectra. Then, some properties of new SAIL were determined including pH,...

A DMAP-catalyzed [4 + 2] annulation of α-substituted allenoates with unsaturated pyrazolones has been achieved in dichloromethane at 40 °C, providing multisubstituted tetrahydropyrano [2,3-c]pyrazoles in good to excellent yields with moderate to good Z/E ratios. The allenoates worked as two-ca...

A synthetic pathway to obtain pure phases of reduced molybdenum phosphates in air is described. Starting from mixtures of MoO3 and (NH4)2HPO4 with different molar ratios Mo/P, and controlling the time and temperature of heating, the compounds: MoOPO4, (MoO)2P4O13, MoP2O and Mo(PO3)3 have been pr...

The effect of zinc dialkyldithiophosphate (ZDDP) addition on the antiwear (AW) and extreme pressure (EP) properties of molybdenum dialkyldithiocarbamate (MoDTC) and molybdenum dialkyl dithiophosphate (MoDTP) are evaluated by standard Four-Ball friction test and also by the determination of coeff...

X-ray photoelectron spectroscopy has been applied to molybdenum phosphate glasses and the core-level binding energies of P 2p, Mo 3d52 and O 1s electrons have been measured. The O 1s spectrum is deconvoluted into two peaks and the variation in the peak areas is discussed in terms of an existing ...

Molybdenum lead phosphate glasses doped with La2O3 of the system xMoO3–5La2O3–50P2O5–(45−x)PbO, with 0≤x≤25 mol%, have been synthesized and studied by FTIR, ultrasonic and differential scanning calorimetry (DSC) in order to investigate the role of MoO3 content on their atomic structure. The...

Admixture of aluminum nitrate, sodium metaphosphate and ammonium hydroxide aqueous solutions yields noncrystalline solid precipitates. Using various aluminum: phosphorus ratios in the reacting mixtures, a range of particulate solids is obtained, the thermal behavior of which depends largely on t...

Two series of glasses have been prepared and characterized. One with varying Li2O/P2O5 ratio and the other with varying Mo/P ratio. The relationship between the formation of the reduced state of molybdenum in phosphate glasses and the type of gases released in heating batch materials has been in...

MoO3-doped lithium phosphate glasses with varying molybdenum contents were prepared and characterized. Combined UV–visible and infrared (FT/IR) spectroscopic studies were measured before and after gamma irradiation. Experimental results indicate that molybdenum ions occupy different local sites...

Glasses in the binary system (100−x)Pb2P2O7xMoO3, with x = 10–80 mol%, were synthesized by conventional melt-quenching technique. Thermal analysis, linear optical absorption, refractive index measurements, Raman scattering and nonlinear (NL) optical experiments were performed to characterize th...