Citral (CIT) is a monoterpene formed by the geranial and neral stereoisomers. CIT is the major compound of Cymbopogon citratus essential oil, commonly known as “lemongrass”, and has demonstrated potential antihyperalgesic, anti-nociceptive and anti-inflammatory effects. However, CIT shows high...

Citral-loaded solid lipid nanoparticles (citral-SLNs) were prepared via a high-pressure homogenization method, using glyceryl monostearate (GMS) as the solid lipid and a mixture of Tween 80 (T-80) and Span 80 (S-80) at a weight ratio of 1:1 as the surfactant. The microstructure and properties of...

The study of drug-DNA interactions is of great importance, as it paves the way towards the design of better therapeutic agents. Here, the interaction of DNA with a therapeutic and prophylactic drug citral has been studied. We have attempted to ascertain the mode of binding of citral with calf th...

Essential oils containing monoterpenes are widely used in pharmaceuticals and cosmetic products on account of their wide range of bioactive properties (including anti-cancer activity). Two monoterpenes (citral and geraniol) were firstly tested for their anti-inflammatory activity in a RAW 264.7 ...

Yeasts are responsible for spoilage of fruit juices and beverages because of their low pH and high sugar content. Their control is generally guaranteed by thermal treatments that however can affect organoleptic and nutritional properties. A strategy to reduce thermal damage is the combination of...

The aim of this study was to investigate the antifungal activity and mechanisms of citral, limonene and eugenol against Zygosaccharomyces rouxii. All the three essential oil ingredients presented strong antifungal activities against Z. rouxii. Minimum inhibitory concentrations of citral, limonen...

Citral-in-water emulsions were prepared with two different essential oil concentrations of 2.5 and 5.0% (w/w), then spray-dried in the presence of the same amount of maltodextrins (20%). The microcapsules were prepared with two different emulsifier compositions: monolayer microcapsules (ML) stab...

Peanut allergens have the potential to negatively impact on the health and quality of life of millions of consumers worldwide. The seeds of the peanut plant Arachis hypogaea contain an array of allergens that are able to induce the production of specific IgE antibodies in predisposed individuals...

Peanut seeds are rich in oil, which exists as oil bodies (OBs). By extraction, peanut crude OBs are obtained and can be used as a food ingredient. In a previous study, it was found that the crude OBs contained an unknown protease, which hydrolyzed the oleosins. This would disrupt the integrity o...

In this study the use of complex coacervation to encapsulate the essential oil (EO) of Lippia turbinata (poleo) and its application for controlling fungal pathogens of peanut seeds were evaluated. High percentages of encapsulation of poleo EO were obtained (99.80%). At the end of storage period ...

Argentinean peanut provides a significant source of food worldwide, therefore is essential to preserve the quality of seeds during the storage period in order to ensure the yield of this crop. In this study in situ effect of a formulation based on microencapsulated boldo (Peumus boldus) essentia...

Seven new zinc(II) complexes, K[Zn(dClQ)3]·2DMF (1), K[Zn(dClQ)3]·2DMF·H2O (2), [Zn(dBrQ)2(H2O)]2·DMF·H2O (3), [Zn(BrQ)2(H2O)]2·H2O (4), (HdClQ)2[ZnCl4]·2H2O (5), [Zn(dClQ)2(H2O)2]·H2O (6) and [Zn(CQ)2(H2O)2] (7) (5,7-dichloroquinolin-8-ol (dClQ), protonated 5,7-dichloroquinolin-8-ol (Hd...

A general method for the preparation of the title compounds from naturally occurring homochiral 2-norbornanones is presented. The key step is the Tf2O induced Wagner-Meerwein rearrangement of the corresponding cyanohydrins.

We found that 2-amino-5-methylphenol was converted to the dihydrophenoxazinone with a reddish brown color by purified human hemoglobin, lysates of human erythrocytes, and human erythrocytes. the reddish brown compound was identified as 2-amino-4,4α-dihydro-4α, 7-dimethyl-3H-phenoxazin-3-one by...

Nitrile oxides 2 reacted with 3-diethylamino 4(4 methoxyphenyl)-isothiazole 1,1 dioxide (1) affording through a highly regioselective 1,3-dipolar cycloaddition reaction isothiazolo[5,4-d]isoxazoline 4,4 dioxides 3. Reduction of 3 afforded a mixture of the E and Z forms of the corresponding 5-(am...

The herein obtained 1-diethylamino-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol or its 1-ethoxy analogue in their reactions with phenols or polyphenols undergo replacement of Et2N/OEt groups with (poly)hydroxyaryl moieties.

A wide variety of small molecules with diverse molecular scaffolds inhibit microtubule formation. In this article we report a one-pot procedure for the preparation of a novel 2-(N-pyrrolidinyl)-4-amino-5-(3′,4′,5′-trimethoxybenzoyl)thiazole in which the size of the substituent at the C-2 posi...

This manuscript describes the synthesis of novel 2-amino-4-aryl-4,10-dihydro-[1,3,5]triazino[1,2-a]benzimidazoles as hydrochloride salts 4a-n and 5b which were prepared in the reaction of cyclocondensation between 2-guanidinobenzimidazole and versatile heteroaromatic aldehydes. Structures of all...

A series of 2-amino-5-bromo-4(3H)-pyrimidinone derivatives bearing different substituents at the C-6 position were synthesized using a highly regioselective lithiation–substitution protocol, and the effect of structural variation at the C-6 position on their antiviral activity in cell culture w...

Methyl triclosan [2,4-dichloro-1-(4-chloro-2-methoxyphenoxy)benzene, 1], which is now considered an environmental pollutant, has been shown to be formed via microbial methylation of triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol, 2]. In the present work, cyclic voltammetry and controlled-pote...