An enantioselective synthesis of (R)- and (S)-3-amino-7-methyl-3,4-dihydro-1H-[1,8]naphthyridin-2-one via an asymmetric reduction and spontaneous cyclisation is reported.

The stereochemistry of the decarboxylation of 3,4-dimethoxycinnamic acids by Saccharomyces cerevisiae and the enzymatic specificity with respect to the substrate structure were studied. This reaction proceeds with retention of configuration at the side-chain double bond as well as enzymatic spec...

Publisher SummaryThis chapter discusses the physical properties, synthesis, stability, pharmacokinetics and metabolism, and analytical methods of iopanoic acid. Iopanoic acid is an orally administered cholecystographic agent that is rapidly absorbed by the gastroenteric tract and is excreted wit...

Room temperature ionic liquids are found to catalyze efficiently the three component-coupling reactions of aldehydes, amines and homophthalic anhydride under mild and convenient conditions to afford the corresponding cis-isoquinolonic acids in excellent yields with high cis-selectivity.

A novel chiral stationary phase (C16-(S)-THIQCA) for ligand exchange high-performance liquid chromatography was prepared by synthesizing 2-(2-hydroxyl) hexadecyl-(S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid as a chiral selector and coating it on ODS-bonded stationary phase. The enantiome...

In this work, two novel bis-azo-linkage Schiff bases (H4L1 and H4L2) containing conjugated group (phenol ring in H4L1 and nitro-phenol ring in H4L2) were synthesized by using new azo-aldehyde compound AZ-1 (3,3′-(4-nitro-1,2-phenylene)bis(diazene-2,1-diyl)bis(2-hydroxy-5-nitrobenzaldeyde). They...

This paper highlights the straightforward and versatile functionalization of biporous poly(2-hydroxyethyl methacrylate) (PHEMA)-based networks obtained from the double porogen templating approach, and their subsequent utilization as efficient catalytic supports in heterogeneous supported catalys...

The synthesis of mono- and di-[4-(n-octyl)phenyl] phosphoric acids, and mono- and di-[4-(1,1,3,3-tetramethylbutyl)phenyl]phosphoric acids and their calcium salts are described as well as certain, IR, NMR, pKa, and chromatographic characteristics.

Solvent extraction of gallium from acidic solutions using octyl phenyl acid phosphate (OPAP) with several different ratios of its components, mono- and di-octyl phenyl phosphoric acids (HM and HD, respectively), has been studied. The extraction is described by four simultaneous reactions, leadin...

A method for preparing the biologically active compound (1R, 2S, 3R)-2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole1 using a palladium (0) catalysed coupling of 1-ethoxymethyl-4-iodoimidazole 2 to the functionalised vinylstannane 3 and the Sharpless catalytic asymmetric dihydroxylation is re...

A method for preparing fluorescent and biotinylated analogues of the biologically active compound (1R, 2S, 3R)-2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole 1 is reported.

We report a 2-(4-amino-2-hydroxyphenyl)benzothiazole based Schiff-base, found to be sensitive to the presence of HSO4− and I− ions as demonstrated by modulation of the various photophysical properties in the presence of these ions in solution and biological enviornments (nematodes). Various spec...

A facile, convenient and one-pot three-component method has been outlined for the synthesis of title compounds by treating equimolar amounts of 3-(2-bromoacetyl)-2H-chromen-2-one (2) with 2-cyanothioacetamide (3) and various aryl/heteryl aldehydes (5 or 7) independently. The effect of solvent an...

A new and efficient synthesis of (2R)-2-amino-5-phosphonopentanoic acid(AP5) is reported. Our approach is based on a pseudo-Claisen [2,3] sigmatropic rearrangement of an alkyne phosphite.

A series of novel (5-oxazolyl)phenyl amine derivatives were synthesized and their antiviral activities against the hepatitis C virus (HCV) and the coxsackie virus B3 (CVB3) and B6 (CVB6) were evaluated in vitro. Bioassays showed that the synthesized compounds 17a1, 17a4, 17a6, 17b1, 17d1, 17e2 a...

A class of N-ethyl dabigatran derivatives was designed based on pharmacological strategies for inhibition of thrombin activity and the structure-activity relationship studies of the previous dabigatran derivatives. Activities of these novel compounds were predicted based on CoMFA model, and most...

Alkylation of malonamic esters provides a direct approach to derivatives of suberoylanilide hydroxamic acid (SAHA) that are branched at the amide carbon atom, a location pivotal for enhancing biological and therapeutic activity. Alkylations use NaH in THF followed by addition of the ester of 6-b...

Single crystals of antimony potassium tartrate were grown from aqueous solution by slow evaporation technique. The grown crystals are characterized using single crystal XRD studies, powdered XRD studies, FT-IR spectroscopy, optical transmission and thermal studies. Single crystal XRD reveals tha...

Highly-dispersed BaLuF5:Yb3+/Er3+ nanocrystals were prepared by a facile potassium sodium tartrate-assisted hydrothermal method. The average particle size was approximately 20–25 nm. The formation mechanism is discussed. Potassium sodium tartrate led to form a complex with an approximately thre...

Crystals of pure and Cu(NO3)2·3H2O doped Rochelle salt (sodium potassium tartrate) crystals are grown from solution at room temperature. The thermal studies such as TGA (thermo gravimetric analysis) shows that there are four stages of decomposition which is confirmed through the four endothermi...