The current study was designed to examine the sulfation of bile acids and bile alcohols by the Zebra danio (Danio rerio) SULTs in comparison with human SULTs. A systematic analysis using the fifteen Zebra danio SULTs revealed that SULT3 ST2 and SULT3 ST3 were the major bile acid/alcohol-sulfatin...

5α-Cyprinol 27-sulfate is the major biliary bile salt present in cypriniform fish including the zebrafish (Danio rerio). The current study was designed to identify the zebrafish cytosolic sulfotransferase (Sult) enzyme(s) capable of sulfating 5α-cyprinol and to characterize the zebrafish 5α-c...

The complexes of 2-aminomethyl benzimidazole, 2-(β-aminoethyl)benzimidazole, and 2-(α-aminoethyl)benzimidazole with Pt(II) and Pd(II) have been prepared.The molecular structure of the free ligands and their complexes were studied by IR and 1H NMR. It was concluded that the substituted benzimid...

A group of Mannich bases, utilizing octamethyleneimine as the amine component, has been prepared. Their preparation and biological activities are given.

Some new physiologically active amides of hepta- and octamethyleneimine moiety have been prepared. Their preparation and biological activities are given.

The effect on retention of the pattern of chlorination in n-C1–C8 monochlorinated acetates, chloroacetates, dichloroacetates and trichloroacetates has been studied at temperatures between 100 and 200°C on a low-polarity (SE-30) and a polar (OV-351) capillary column. The work extends earlier st...

A series of novel N-substituted arylidene, pyrazole, thioxopyrimidine and thiazolopyrimidine derivatives 2–7 were synthesized by initial reactions of 2-methyl-cyclohexanone with aromatic aldehydes to give 2,6-dibenzylidene-3-methylcyclohexanone 2. Some of the synthesized compounds were tested a...

Sodium pyroantimonate was prepared by pressure oxidation from sodium thioantimonite solution. The effects of temperature, NaOH concentration, oxygen partial pressure, stirring speed and reaction time on the oxidation precipitation ratio of antimony and the distribution ratio of different sulfur ...

The pressure oxidation process to prepare sodium pyroantimonate from sodium thioantimonite solution was optimized. The results indicate that increasing reaction temperature, oxygen partial pressure and stirring speed can significantly accelerate the oxidation precipitation rate of Sb. A decrease...

6-Aminochrysene and 2-aminoanthracene were activated to metabolites which were mutagenic to Salmonella typhimurium TA98 by hepatocytes or hepatic 9000 × g supernatants (S9s) from control or xenobiotic-treated rats. Hepatocytes from Aroclor-1254-treated rats were more efficient than hepatocytes ...

Absorption and fluorescence spectra obtained in various solvents indicate that the amino group acts as a hydrogen acceptor in the S0 state and a hydrogen donor in the S1 state. The lack of correspondence between the disappearance of 6-aminochrysene (CNH2) and the appearance of CNH3+ in the fluor...

3-Aminochrysene, a mutagenic geometric isomer of the mutagenic and carcinogenic aromatic amine 6-aminochrysene, has been synthesized and its metabolic activation studied by characterization of the products formed from the reaction of metabolites with calf thymus DNA. DNA adducts produced by 3-am...

In the course of the development of N-phenyl-N′-(2-chloroethyl)ureas (CEUs) as potential antineoplastic agents, we investigated the effect of carbonylated substituting chains of the aromatic ring of CEU on their covalent binding to the colchicine-binding site (C-BS). In this study, we found tha...

A pragmatic approach for preparing glycoconjugates of complex oligosaccharides is to prepare the oligosaccharide as a building block with most of its protecting groups exchanged to protecting groups whose cleavage and other manipulations are highly compatible with the functional groups of comple...

A series of novel 5-methyl-2-phenylthiazole-4-substituted-heteroazole derivatives (6–15) have been synthesized. The structures of these compounds were established by IR, 1HNMR, Mass spectral data and elemental analyses. Compounds were evaluated for their anti-inflammatory and analgesic activiti...

Report is about the synthesized new range of oxadiazole substituted quinazoline and studied its electronic distribution to attribute fluorescent properties. B3LYP Density Functional Theory (DFT) computational optimization was studied to observe the effect of electron donor and acceptor substitue...

In this study, a novel decontamination method against mustard agent simulant 2-chloroethyl ethyl sulfide (CEES) was conducted with 30% H2O2 aqueous solution in 1-butyl-3-methylimidazolium based ionic liquids (ILs). More than 99% of the CEES was oxidized within H2O2/[BMIm]HCO3 at a concentration ...

1-O-Acetyl-2,3-dideoxy-3-C-(hydroxymethyl)-4-thiofuranose derivative was synthesized from (S,S)-1,4-bis(benzyloxy)-2,3-epoxybutane derived from (+)-diethyl L-tartrate and the enantiomerically pure (E)-5-(2-bromovinyl)-1-[2′, 3′-dideoxy-3′-C-(hydroxymethyl)-β-D-4′-thiopentofuranosyl]uracil4 ...

Optically active cyclopropane derivatives were prepared by a novel, simple and green approach in high enantioselectivities using monosaccharide-based chiral crown ethers as phase transfer catalysts. The crown ethers having d-glucopyranoside, d-mannopyranoside and d-altropyranoside units proved t...

The structures of α-lithiated vinyl ethers were explored on the basis of a combined computational and NMR study. Calculations (M06/6-31 + G(d)) on free energies of aggregate formation for a series of α-lithiated vinyl ethers indicated that the tetramer is generated preferentially in both the g...