The structure and the vibrational frequencies of the fundamental modes of the optimized geometry of N-(phenyl)-2,2-dichloroacetamide (NPA), N-(2-chloro phenyl)-2,2-dichloroacetamide (2CPA) and N-(4-chloro phenyl)-2,2-dichloroacetamide (4CPA) have been determined by DFT/B3LYP method. A detailed v...

N-(3-chloro-4fluoro-phenyl)-7-methoxy-6-(3-morpholin-4ylpropoxy)-quinazolin-4-amine (GEF), a quinalizoline derivative used as new anti-cancer agent, designed to target activity of epidermal growth factor receptor (EGFR) promoting the growth, division and spread of cancer cells, was examined from...

A novel series of sulfonamide derivatives 4–21 have been synthesized starting from the strategic starting material (E)-4-Chloro-N-(4-(1-(2-(2-cyanoacetyl)hydrazono)ethyl)phenyl) benzenesulfonamide 4. Two series of hydrazone 5–9, and pyridone 10–21 derivatives bearing a sulfonamide moiety were...

Synthesis and structural assignment of four trigonal planar copper(I) complexes (1a–4a) having the general formula [Cu(CH3OCONHCSNHR)2Cl] where R = 2-methoxyphenyl (1), 4-methoxyphenyl (2), 2-chloro 4-nitrophenyl (3) and 2-methoxy 4-nitrophenyl (4) have been described. The characterization were...

Bis(2-ethylhexyl)phosphate (HDEHP) as an acidic extractant selective for lanthanides was impregnated into an alkylamino group introduced into a polymer chain grafted onto the pore surface of a porous hollow-fiber membrane. The alkyl chain length was varied from 2 to 18 carbons by reacting the gl...

Synthesis of a new series of phospholipid analogues to serve as activity-based probes of secretory phospholipase A2 enzymes is reported. The synthesis is based upon (1) preparation of long-chain esters and amides of glyceric acid, followed by (2) regioselective derivatization of the diol functio...

A novel vanadium dodecylamino phosphate was synthesized by mixing phosphoric acid and vanadyl acetylacetonate with dodecylamine at ambient temperature. The material was characterized by various spectroscopic and analytical techniques to know its morphological and structural characteristics. The ...

A novel titanium dodecylamino phosphate has been synthesized instantly at ambient temperature and characterized by various analytical and spectroscopic techniques such as PXRD, SEM-EDAX, TGA/DTA, FT-IR, dispersive Raman, UV–Vis DRS, XPS, 31P and 13C MAS NMR. The material was tested for biologic...

Bioadhesive poly(anhydride) nanoparticles coated with mannose (M-NP) or Salmonella Enteritidis derived flagellin (F-NP) were designed to be applied in oral vaccination strategies using ovalbumin (OVA) as antigen model. Nanoparticles formulations (OVA-M-NP, OVA-F-NP and control OVA-NP) were chara...

Objective: To investigate the effect of long-term exposure to glucosamine or mannosamine on the catabolism of aggrecan by explant cultures of bovine articular cartilage maintained in the presence of retinoic acid.Design: The kinetics of loss of 35S-labeled and total aggrecan from explant culture...

Mannosamine (2-deoxy-2-amino-d-mannose) is unable to block GPI biosynthesis in Plasmodium falciparum: neither parasite development nor GPI biosynthesis were blocked by mannosamine treatment in P. falciparum cultures. Further, it was shown by metabolic labeling with [3H]mannosamine and subsequent...

A detailed study of Zn(II)-D-mannosamine and mixed ligand complex Zn(II)-D-mannosamine-glycine in aqueous solution (θ = 25 °C, Ic = 0.55 mol L⿿1) was carried out by voltammetry and potentiometry, allowing their characterization. Redox process of the [ZnManN]2+ complex was registered at Ep ⿼ ⿿1...

Quaternary ammonium salts containing the t-heptyl group have been synthesized for the first time. The new compounds are water-soluble tris(t-heptyl)(n-propyl)ammonium bromide and sparingly water-soluble tris(t-heptyl)(n-pentyl)ammonium bromide (tris(t-heptyl)PeAB). Both compounds were found to b...

Two subtypes of cannabinoid receptors are currently recognized, CB1, found in brain and neuronal cells, and CB2, found in spleen and immune cells. We have characterized 1-(2-chlorophenyl)-4-cyano-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid phenylamide (CP-272871) as a novel aryl pyrazole a...

A series of benzoylpiperidine analogs related to 4a was prepared, and their ability to inhibit the uptake of [14C]-glycine in COS7 cells transfected with human glycine transporter type-2 (GlyT-2) was evaluated. Small structural changes to the benzoylpiperidine region of the molecule led to a sig...

5-Deazaflavins and their homologues have been known as potential riboflavin antagonists, bioreductives, and compounds with potent antitumor activity. 2-Amino-4-methylquinoline-3-carbonitrile (2) was prepared as unreported starting material for several interesting 2-deoxo-5-deazalloxazine derivat...

A new hybrid composite proton exchange membrane has been synthesized from dihydrogen phosphate functionalized imidazolium ionic liquid (IL-H2PO4), graphene oxide, and Nafion 117 solution. The chemical structure and thermal stability of the dihydrogen phosphate functionalized imidazolium ionic li...

ObjectivesTo examine whether solvents and changing the molecular structure of 10-Methacryloyloxydecyl dihydrogen phosphate (10-MDP) affect its chemical affinity to Yttria-stabilized tetragonal zirconia polycrystals (Y-TZP).

ObjectiveWe determined the amounts of calcium salt of 10-methacryloyloxydecyl dihydrogen phosphate (MDP-Ca salt) and dicalcium phosphate dihydride (DCPD) with an amorphous phase developed during the application of commercial MDP-based all-in-one adhesives to enamel and dentin. This is because th...

The solubility values of potassium dihydrogen phosphate in binary mixtures of acetone + water, ethyl acetate + water, and thiourea + water were measured using a gravimetric method in a temperature range of (298.15–313.15) K. All results from these measurements were correlated using a simplified...