The first chloramphenicol base-derived thiourea-catalyzed enantioselective Michael addition of malononitrile to α,β-unsaturated ketones is reported. The Michael adducts were obtained in good to excellent yields (up to 98% yield) and enantioselectivities (up to 94% ee). This reaction has a broa...

Various diaryl ketones, alkyl aryl ketones, and dialkyl ketones were efficiently prepared in good yields by the reactions of the Grignard reagents derived from aryl or alkyl bromides, followed by the reactions with aromatic or aliphatic aldehydes and the subsequent treatment with 1,3-diiodo-5,5-...

The conjugation of Pt nanoparticles with ClGa(III) 5,10,15,20-tetrakis-(4-carboxyphenyl) porphyrin (ClGaTCPP) showed greater antimicrobial activity against a gram positive and drug resistant bacteria Staphylococcus aureus, than when the porphyrin was used alone. ClGaTCPP and its conjugate with p...

Three different routes have been investigated for the preparation of 6-aryl-N-(1-arylethyl)thienopyrimidin-4-amines. First the possibilities of selective Suzuki reactions on 6-bromo-4-chlorothienopyrimidine were investigated. The preference for mono arylation at C-6 could be increased, in the ca...

The regioselectivity of the FeCl3-promoted cleavage of the title compounds was studied : 2-(1,1-dichloroalkyl)cyclohexanones were obtained which were converted to 2-(l-chloroalkylidene)cyclohexanones by dehydrochlorination.

The catalytic conversion of substituted and unsubstituted cyclohexanones to the corresponding enones and aromatic alcohol catalyzed by Pd, Pd-1, Pd-cube, Cu, Ni, [email protected] and Ni-Sn nanocatalysts has been studied in the presence of O2 as the oxidant without using any additives i.e. acid ...

Synovial fluid is a ∼0.15 % (w/v) aqueous solution of hyaluronic acid (HA), a polysaccharide consisting of alternating units of GlcA and GlcNAc. In synovial fluid of patients suffering from rheumatoid arthritis, HA is thought to be degraded either by radicals generated by Fenton chemistry (Fe2+...

The pair of stereoisomeric polyamides PA-6dAr and PA-6lAr, as well as the racemic stereocopolyamide PA-6dlAr was synthesized from hexamethylenediamine and 2,3,4-tri-O-methyl-arabinaric acid (d, l and their equimolar mixture, respectively). All these polyamides were aregic, thermally stable and d...

This article describes discovery of 29 novel bisindolylmethanes consisting of thiourea moiety, which had been synthesized through three steps. These novel bisindolylmethane derivatives evaluated for their potential inhibitory activity against carbonic anhydrase (CA) II. The results for in vitro ...

In order to discover novel Hsp90 inhibitors targeting the C-terminal ATP binding pocket, a novobiocin derivative based ROCS model was constructed for virtual screening. Compound 13 was identified as the lead compound and then systematical structure activity relationship (SAR) study was conducted...

2-(2-Benzamido)ethyl-4-phenylthiazole (1) was one of 1035 molecules (grouped into 115 distinct scaffolds) found to be inhibitory to Trypanosoma brucei, the pathogen causing human African trypanosomiasis, at concentrations below 3.6 μM and non-toxic to mammalian (Huh7) cells in a phenotypic high...

The new nonionic glycosidic surfactant N-octanoyl-β-D-glucosylamine (NOGA, molar mass 305.37 g) was synthesized through an easy and efficient two-step procedure. Specifically, β-D-glucosylamine was obtained by the replacement of the anomeric hydroxyl of D-glucose by an amino group which was th...

This work discusses the theoretical ([TD]DFT) and spectroscopic investigation into 2-Hydroxy-N-(2-phenylethyl)benzamide (SAL3) and its physiochemical behaviour in the selected organic solvents. The compound demonstrated a dual fluorescence effect in alcoholic solutions (methanol, ethanol, isopro...

High-resolution rotational spectra were recorded for 2-phenylethyl methyl ether and the 2-phenylethyl methyl ether – argon complex using a cavity-based Fourier transform microwave spectrometer. The spectra were assigned to the aao and g−ao monomer conformations and the g−ao – argon complex. Sm...

Fifteen previously undescribed 2-(2-phenylethyl)chromone dimers, along with two known analogues were isolated from Chinese agarwood (Aquilaria sinensis) by a LC-MS-guided fractionation procedure. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR...

This work focuses on the non-ideal phase equilibrium of methacrylate and acetate groups with weak polar. Phase behavior measurements were performed using a synthetic method by observing the bubble-point and cloud-point in a variable volume high-pressure view cell. The cloud-point and vapor-liqui...

Publisher SummaryThe chapter discusses later work on glycosiduronic acids and their derivatives from chemical point of view. As a consequence of the biological importance and general interest in the chemistry of Dglucosiduronic acids, the chapter is mainly concentrated around those conjugates ha...

Two procedures for the synthesis of barely accessible 8-chloro-3,4-dihydroisoquinoline were investigated. The first approach is based on a directed ortho-lithiation of N-pivaloyl meta-chlorophenylethylamine, followed by formylation and subsequent ring closure under acidic conditions. In the seco...

A series of N’-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene] 2/4-substituted hydrazides were synthesized using appropriate synthetic route and characterized by elemental analysis and spectral data. The anticonvulsant activity of some of the synthesized compounds were evaluated against...

A series of new N'-(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)-1-(5-phenyl-1H-pyrazol-1-yl)amidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cance...