4-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene) amino]-N(4,6-dimethyl-2-pyrimidinyl)-benzene sulphonamide and its derivatives were synthesized by reaction of isatin and its derivatives with sulphadimidine. Their chemical structures have been confirmed by IR, 1H NMR data and elemental analysis. Investi...

Eight rare earth metal (III) complexes with 2-(((4,6-dimethyl)-2-pyrimidinyl)thio)-acetic acid, LnL3-nH2O [HL = 2-(((4,6-dimethyl)-2-pyrimidinyl)thio)-acetic acid; Ln = La, Ce, Pr, Nd, Sm Eu, Gd, Tb; n = 4 or 5], were prepared and characterized by elemental analysis, complexometric titration, th...

In this work, the oxidation experiments of Ti(C,N)- 304 stainless steel (304ss) cermet were carried out at 650 °C in the air. Abnormal oxidation behavior of Fe in the Ti(C,N)- 304ss cermet was observed for the first time, and it was investigated by field emission scanning electron microscope (F...

The (S, N) co-doped Ba2In2-xCrxO5+y (0 ≤ x ≤ 0.5) oxides are successfully obtained by mixing the Ba2In2-xCrxO5+y oxides and thiourea through a simple ball milling method followed by sintering at 400 °C for 3 h. The colors of the compounds change from orange-brown to yellow-green after reactin...

To further enhance electrochemical performance of WS2-based materials in supercapacitors, a 3D architecture with WS2 nanoflakes interconnected and quantum dots anchored on N and S co-doped reduced graphene oxide (WS2/N,S-rGO) crumpled nanosheets is fabricated for the first time via a novel, faci...

The synthesis of a still-unknown member of the physiologically interesting 16-unsaturated C19 steroids-androsta-4, 16-diene-3, 6-dione — is described. The spectroscopic data of the new compound are reported.

Chiral rhodium[bis(oxazolinyl)phenyl] complexes exhibited high catalytic activity for the β-boration of α,β-unsaturated esters, ketones, and amides with bis(pinacolato)diboron in the presence of sodium tert-butoxide to attain high enantioselectivity of up to 97%. The substrate scope and catal...

Cerium ammonium nitrate (CAN) removed hydroxyethyl units from 2-hydroxyethyl ethers and 2-hydroxyethyl amines to produce alcohols and amines in good yields. Especially, removal of the 2-hydroxyethyl ethers from C2-symmetric diols, chiral 2,3-butanediol and chiral hydrobenzoin, was very useful fo...

Four pyrazolopyrimidine series were prepared with a substitution at position- 4 by Schiff base, triazole, oxadiazole and pyrazole moieties (7a-f, 8a,b, 9a-f, 10a,b and 13a,b), respectively. All the synthesized compounds were evaluated in vitro against COX-2 and in vivo against carrageenan-induce...

The synthesis of two novel series of 1-(4-chlorophenyl)-4-hydroxy-1H-pyrazoles linked to either polysubstituted 1H-pyrazole counterparts through a carbonyl bridge, or to some biologically-active nitrogenous heterocycles by an amide linker, is described. Ten of the newly synthesized compounds wer...

As a continuous effort to develop novel antitumor agents, a new series of forty-five 2-phenol-4-aryl-6-chlorophenyl pyridine compounds were synthesized and evaluated for cytotoxicity against four different human cancer cell lines (DU145, HCT15, T47D, and HeLa), and topoisomerase I and II inhibit...

Synthesis of the 9Z and 9Z, 11E isomers of leukotriene C4 is described, the stereochemistry of the former was confirmed by its facile 1,7 hydride shift reaction.

Starting from (7E,9Z)-C15-aldehyde 4, the syntheses of (9Z, 11Z)-vitamin A acetate and palmitate are reported. The construction strategy is based on treatment of 4 with Zn-PPh3/CBr4, addition of acetaldehyde followed by a Wittig-Horner reaction to give the (9Z, 11Z)-C20-nitrile 7 which was reduc...

Two approaches to stereoselective synthesis of steroid 5Z,9Z-dienoic acids were developed, the first one being based on the cross-cyclomagnesiation of 2-(hepta-5,6-dien-1-yloxy)tetrahydro-2H-pyran and 1,2-diene cholesterol derivatives on treatment with EtMgBr catalyzed by Cp2TiCl2, while the oth...

Hybrid molecules based on a number of steroids (cholesterol, pregnenolone, androsterone) and 1,14-tetradeca-5Z,9Z-dienedicarboxylic acid linked via mono- and diethylene glycol spacers were synthesized for the first time and studied for antitumor activity in vitro. The acid was prepared using cat...

Synthetic analogues of natural 5Z,9Z-dienoic acids - hybrid molecules based on the oximes of cholesterol, pregnenolone, and androsterone with 1,14-tetradeca-5Z,9Z-dienedicarboxylic acid - were synthesized for the first time and studied for antitumor activity in vitro. The acid was prepared using...

Nowadays a few ways to synthesize 5-azidomethyl-2′-deoxyuridine from 5-hydroxymethyl-2′-deoxyuridine have been reported. But none of them was one-step. And many of them need to protect the hydroxyl group on the pentose ring. The detection of 5-hydroxymethyl-2′-deoxyuridine is also very import...

A liquid chromatographic method with UV detection was developed to analyse 5-hydroxymethyl-2-furfural and its main metabolite 5-hydroxymethyl-2-furoic acid in urine. For the analysis on a reversed phase column was used with 5% methanol in water and 5 mM tetramethylammoniumhydrogen sulphate as io...

Safety uncertain was always a problem related to the Maillard reaction in heat treatment at a presence of carbohydrate. Early researches have detected caramel color contains 5-hydroxymethyl-2-furaldehyde which is toxic and should be removed from caramel color as much as possible. In the present ...

A potentiometric method was described for the determination of iron(III) in petroleum water samples using modified carbon paste and screen-printed sensors. These sensors were embodied with multi-walled carbon nanotubes (MWCNTs) since it improved the performance of the sensors in presence of (met...