Flufenoxuron is a widely used pesticide to inhibit the synthesis of chitin during insect development and its effect on the growth of lizards has been little addressed. The hypothalamus-pituitary-thyroid (HPT) axis plays an important role on the development of lizards. In this study, the lizards ...

More and more studies are focusing on toxic effect of pesticides on lizards. However, the responses of different life-stage lizards to pesticides have not been reported. In this study, according to RNA-seq library data, thyroxine 5′-deiodinase activity showed significant difference between matu...

Four series of 2-substituted-4-morpholino- 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine derivatives (9–28) were designed, synthesized and their structures were confirmed by 1H NMR, 13C NMR and MS spectrum. All compounds were evaluated for the IC50 values against three cancer cell lines (A549, PC-...

A library of 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyrans has been synthesized as a new family of non-peptide NK1 receptor ligands by a one-pot cascade process. Their biological effects via interaction with the NK1 receptor were experimentally determined as percentage of inhibition...

After being used for decades in clinical screening, dried blood spots (DBS) have recently received considerable attention for their application in pharmacokinetic and toxicokinetic studies in rodents. The goal of this study was to develop and apply a DBS-based assay for a pharmacokinetic study o...

Reaction products of NAD with 3-propiolactone at pH 6 showed that 3-propiolactone not only alkylates at the N-1 position of the adenine ring of NAD, but also reacts with other positions on NAD and its derivatives. Modifications other than the N-1 alkylation lowered the yield of N6-(2-carboxyethy...

Molecular recognition capabilities of a novel nucleolipid amphiphile, octadecanoyl ester of 1-(2 carboxyethyl) adenine, to the complementary nucleobases at the air/water interface were investigated by surface pressure–area (π–A) isotherms and UV spectra measurements. All of the observations s...

A new single-chain nuclei acid base-containing amphiphile, octadecanyl ester of 1-(2-carboxyethyl)thymine, was synthesized, and its surface behaviors on pure water and on aqueous solutions of adenine were investigated by the method of surface pressure-area (π-A) isotherms. Molecular recognition...

Fourier transform infrared (FTIR) transmission, polarized transmission and attenuated total reflection (ATR) spectroscopy were employed to investigate the molecular recognition capabilities of a novel nucleolipid amphiphile, octadecanoyl ester of 1-(2-carboxyethyl) adenine, to the complementary ...

In vitro reaction of β-propiolactone (BPL) with calf thymus DNA and mouse liver DNA followed by acid (HCl) hydrolyses of the BPL-reacted DNA's resulted in the isolation of a new compound, 1-(2-carboxyethyl)adenine (1-CEA). The structure was assigned on the basis of ultraviolet spectra at a...

The new adduct N6-(2-carboxyethyl)adenine (N6-CEA) was prepared from 1-(2-carboxyethyl)adenine (1-CEA) by base catalyzed (Dimroth) rearrangement of 1-CEA. The structure of N6-CEA was assigned on the basis of UV spectra and electron impact and isobutane chemical ionization mass spectra. When the ...

[4-t-Butyl-2,6-bis(1-methoxy-1-methylethyl)phenyl]phosphine, [4-t-butyl-2,6-bis(2-methoxy-1,1-dimethylethyl)phenyl]phosphine, and [4-t-butyl-2,6-bis(3-methoxy-1,1-dimethylpropyl)phenyl]phosphine were prepared and allowed to react with sulfur or selenium, to give heterocyclic compounds containing...

The pheromone of the Japanese beetle, [R-(Z)]-5-(1-decenyl)dihydro-2(3H)-furanone (7), has been synthesized efficiently in high enantiomeric purity via 1,2-dicyclohexyl-1,2-ethanediol boronic esters. The synthetic route involves reaction of an α-chloro boronic ester with an alkynyllithium, and ...

Fluorescence labeling of the target molecules using a small molecule-based probe is superior than a method using genetically expressed green fluorescence protein (GFP) in terms of convenience in its preparation and functionalization. Fluorophore-nitrilotriacetic acid (NTA) conjugates with severa...

Several Salvia species have received due scientific attention regarding their therapeutic virtues, yet little is known about the pharmacological potential of Salvia viridis L. roots. This study, therefore, attempts to explore the phytochemical composition, enzyme inhibitory potential, and antiox...

Salvia sclarea is a traditional medicinal and aromatic plant that grows in Europe and produces various economically important compounds, including phenylpropanoid derivatives and terpenoids. Methyl jasmonate (MeJA) is commonly used to elicit plant stress responses. However, how MeJA enhances pro...

Salvia sclarea L. is traditionally used to manage common human ailments and is consumed as a food product. This study aimed to establish the phytochemical profile and antioxidant potential of ethyl acetate, methanol, and water extracts of Salvia sclarea. The inhibitory action of the extracts aga...

Ethnopharmacological relevanceSalvia sclarea L., clary, is an aromatic plant traditionally used in folk medicine for the treatment of various diseases and conditions. Although it has been primarily used as a stomachic, there are data on traditional use of S. sclarea as an agent against gingiviti...

Hydrodebromination of aryl bromides catalyzed by electron rich and sterically unhindered cobalt 5,10,15,20-tetrabutylporphyrin was achieved at mild conditions in good yields employing EtOH as the hydrogen source. The catalytic efficiency was enhanced compared with previously reported by cobalt t...

The successive treatment of aryl bromides with n-BuLi, DMF, hydroxylamine hydrochloride, and finally diphenylphosphoryl azide provided efficiently the corresponding 5-aryltetrazoles in good to moderate yields. Similarly, the successive treatment of aryl bromides with n-BuLi, DMF, hydroxylamine h...