Diphenylacetylenes containing electron-donating groups (O-n-C8H17: 1A, OCH3: 1B, SCH3: 1C) and electron-withdrawing groups (COOCH3: 1a, COCH3: 1b, CF3: 1c, CN: 1d) were polymerized using TaCl5/n-Bu4Sn. The polymerization of diphenylacetylenes possessing both an n-octyloxy group and an electron-w...
The chronic administration of 10 mg/kg/day of dipyridamole to rats produced 33.7% inhibition of platelet aggregation induced with ADP and a 93% increase in 6-keto-prostaglandin F1α (6-keto-PGF1α) in vascular samples, versus saline-treated rats. Mopidamol, 8.3 mg/kg/day, caused 50.6% inhibition...
1.1. The in vitro production of ferrous-induced lipid peroxidation was 5.71 times higher in rat lung tissue than in human lung membranes.2.2. The pyrimido-pyrimidine derivative RA-642 shows a more potent inhibition of ferrous-induced lipid peroxidation than dipyridamole; mopidamol had no effect....
We compared the effects of dipyridamole, RA-642, and mopidamol on platelet activity and thromboxane/prostacyclin balance in relation to the degree of retinal vascularization in a model of experimental streptozotocin-induced diabetes in rats. After 3 months, collagen-induced platelet aggregation ...
Pentachloroaniline, 2,3,5,6-tetrachloroaniline, 2,3,4,6-tetrachloroaniline, and 2,3,4,5-tetrachloroaniline were identified as metabolites of pentachloronitrosobenzene in livers of female rats.
An efficient method for the formation of α-carbonyl-monosubstituted acetophenones from ortho-methoxy- and ortho-hydroxy-α,α-dibromoacetophenones and a range of selected nucleophiles, occurring via a carbophilic substitution/bromophilic substitution/protonation cascade process, is described. I...
We report a useful method for facile aerobic photo-oxidative synthesis of α,α-dibromoacetophenones from aromatic alkynes with 48% aq HBr. This method provides the synthesis of α,α-dibromoacetophenones using inexpensive and easily handled bromine sources, harmless visible light, and molecular...
The facile synthesis of α,α-dibromoacetophenones from ethyl-substituted aromatics by aerobic photooxidation has been developed. This synthetic method achieves oxidative dibromination of aromatic ethyl groups by using inexpensive and easily handled bromine sources, harmless visible light and mo...
A novel method for the preparation of α,α-dibromoacetophenones from aromatic alkenes was reported. This procedure was mediated by 1,3-dibromo-5,5-dimethylhydantoin, which served as bifunctional reagent, proceeding oxidation and bromination in one-pot.
A series of novel N-methylated derivatives of pyridinium amine, [L1][Tf]-[L5][Tf], were synthesized and characterized by FTIR, NMR, MS and XRD analyses. Preliminary biological screening of these compounds including antioxidant, enzyme inhibition and DNA (salmon sperm) interaction studies were al...
Chelating potential of N,2′-DPAHA with 3d metal ions such as Cu(II), Ni(II), Co(II), Zn(II), and Cd(II) in the presence of Gly and Phen has been investigated. These experiments were designed to study the role of the stability of mixed-ligand complexes in the modulation of its fungicidal potenti...
A four-step synthesis of 3a-aryloctahydroindol-4-ones (1) in which the key step is the ozonolysis of 2-allyl-2-(o-nitrophenyl)-1,3-cyclohexanedione (5) followed by reductive aminocyclization was been accomplished. An asymmetric synthesis of the bicyclic system 1 from chiral amines is achieved by...
A series of novel optically active β-enaminones have been prepared regio- and stereoselectively from primary and secondary amines (pyrrolidine, cytisine salsoline and 2-amino-1-(4-nitrophenyl)propane-1,3-diol) and (+)-3-carene-derived β-chlorovinylketone. Resolution of the isoquinoline alkaloi...
The synthesis of the racemic hexahydro-2H-imidazo [4,5-g] isoquinolin-2-one 15 (BW2247W94), a 6,7-ureylene isostere of the 6,7-dihydroxy-tetrahydroisoquinoline 1 (BW32C73), has been achieved in ten stages from 4-nitrobenzyl cyanide 5. The key step is a selective reduction of the nitrile 8 to the...
Selective openings of the ring B of the derivative hexapyrroloindol in basic conditions confirm the rearrangement of the tryptophan to aminoarylpyrrol, analogously to the step catalyzed by the enzyme prnB in the biosynthesis of pyrrolnitrin.
In this Letter we present a method for the synthesis of N-acyl-N′-arylhexahydropyrimidines 1, by ring closure of N-acyl-N′-aryl-1,3-propanediamines 3 with formaldehyde. Cyclodehydrations were performed in aqueous medium under microwave irradiation, and led to high yields of the desired compoun...
In this Letter we present the synthesis of hitherto unreported 1-aryl-2-alkyl-1,4,5,6,7,8-hexahydro-1,3-diazocines 1. Cyclic amidines 1 were synthesized by PPSE promoted ring closure of N-acyl-N′-arylpentamethylenediamines 2. The cyclodehydration reaction was performed under microwave irradiati...
A series of N-(2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethyl)acylamides was synthesized and evaluated for binding affinity and intrinsic activity at melatonin receptors. The affinity of each compound for the melatonin receptors was determined by binding studies on cloned human MT...
A series of 3-substituted-4-chloro-thioxanthones and their corresponding S,S-dioxidethioxanthone derivatives were designed and synthesized. The effects of our synthesized compounds on cell viability toward the MCF-7 and MDA-MB-468 breast cancer cell lines were evaluated. The most active compound...
The crystal and molecular structure of [(p-chlorophenylthio)methyl]tricyclohexylstannane (II) has been determined. In the two independent molecules of monoclinic II there are slightly distorted tetrahedral geometries about tin with intramolecular SnS distances of 3.29(1) and 3.26(1) Å. Compoun...
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View