Tetrahydroperfluorocarboxylic acids (2H,2H,3H,3H-PFCAs) have aroused the interest of scholars worldwide due to their potential to generate perfluorinated compounds. In this work, we systematically examined the photodegradation kinetics and mechanisms of typical 2H,2H,3H,3H-PFCAs (CnF2n+1C2H4COOH...
This study presents a novel data set of noble gas compositions and 3H/3He measurements in groundwater samples from the Gardermoen Aquifer in Norway. The motivation was to test the applicability of noble gases as tracers in constraining the conceptual model and improve the understanding of deeper...
Bubbling systems are among the devices most used by nuclear operators to measure atmospheric tritium activity in their facilities or the neighbouring environment. However, information about trapping efficiency and bubbling system oxidation is not accessible and/or, at best, only minimally suppor...
The present work was attempts to develop rapid and accurate alternative analytical method for measuring naturally occurring radioactivity in the crude phosphoric acid (CPA). The measurements were achieved using nuclear method based on the non-destructive γ-ray measurements; and non-nuclear meth...
The effects of hydrofluoric acid concentration ([HF]), silicon particle size, calcination and quenching (C&Q), in addition to complexation with various ligands on the purification of metallurgical grade silicon (MG-Si), which was achieved via leaching with mixed nitric acid (HNO3) and HF acid, w...
The success in exploring anti-tubercular potency of nitroimidazole and quinoline, the core moieties of recently approved anti-tubercular drugs instigated us to synthesize a series of alkylated/aminated 2-methyl-5-nitroimidazoles and nitroimidazole-7-chloroquinoline conjugates and to evaluate the...
The present study presents easy and rapid methods to synthesize new benzo[h]chromene and benzo[h] quinoline derivatives. Cytotoxic evaluations of most of the examined compounds indicated that they had significant cytotoxic activities against HepG-2 (human cancer cells) and MCF-7 (breast cancer c...
A series of new 6-methoxyquinoline-3-carbonitrile derivatives were synthesized using a variety of synthetic routes. The newly synthesized compounds have been characterized by IR, 1H NMR, and mass spectral data followed by elemental analysis. All of the synthesized compounds were evaluated for th...
A Gould-Jacobs cyclization enabled the synthesis of several novel, so far undescribed 3,4,6-trisubstituted quinoline derivatives. They all bear substituents which are well-suited for further transformations, e.g. carboxylic acid or ester functions, halogens, terminal alkynes and hydroxyl groups....
This review integrates and gives analysis of published data about the synthesis of quinolines by the reactions of anilines with aldehydes, alkenes, alkynes, alkyl amines, allyl amines, alcohols, 1,2-diols, and 1,3-diols using metal complex catalysts based on Ru, Pt, Rh, Pd, Ir, In, Mo, Co, Bi, G...
The advent of Camptothecin added a new dimension in the field anticancer drug development containing quinoline motif. Quinoline scaffold plays an important role in anticancer drug development as their derivatives have shown excellent results through different mechanism of action such as growth i...
The recent developments in the use of natural quinoline products and synthetic quinoline-based molecules as antiparasitic agents for Chagas disease (CD), African sleeping sickness (human African trypanosomiasis, HAT), and leishmaniasis (LE) are reviewed in this chapter. Classical and contemporar...
Copper-catalyzed vinylation of 2- and 4-hydroxy pyridine and quinoline affords exclusively N-vinylation products. However, vinyl ethers of 4-hydroxy pyridine and quinoline can be prepared via a three-step sequence involving copper-catalyzed C-O cross coupling reaction of the corresponding N-hete...
Among heterocyclic compounds, quinoline scaffold has become an important construction motif for the development of new drugs. Quinoline and its derivatives possess many types of biological activities and have been reported to show significant anticancer activity. Quinoline compounds play an impo...
A series of novel 7-bromo substituted derivatives of quinolinecarboxylate (4a–i) have been synthesized with short synthetic route and high yields. The structures were confirmed by 1H NMR, IR and MS. Anticoccidial activities of these compounds were evaluated according to the ACI (the anticoccidi...
The P2X7 receptor (P2X7R) plays an important role in diverse conditions associated with tissue damage and inflammation, suggesting that the human P2X7R (hP2X7R) is an attractive therapeutic target. In the present study, the synthesis and structure-activity relationship (SAR) of a novel series of...
An effective approach was proposed to the derivatization of seven biogenic amines using 3-(4-fluorobenzoyl)-2-quinolinecarboxaldehyde (FBQCA) as a fluorogenic reagent. The sensitive determinations of these derivatives were achieved by micellar electrokinetic capillary chromatography (MEKC) with ...
In the present study, the FT-IR and FT-Raman spectra of 2-chloro-3-quinolinecarboxaldehyde (2Cl3QC) have been recorded in the region 4000–400 and 3500–50 cm−1, respectively. The fundamental modes of vibrational frequencies of 2Cl3QC are assigned. Theoretical information on the optimized geomet...
Combined experimental and theoretical studies have been performed on the structure and vibrational spectra (IR and Raman spectra including far region) of 3-quinolinecarboxaldehyde. Hartree–Fock (HF) and density functional theory (DFT) B3LYP calculations have been employed with the 6-311++G(d,p)...
A novel and efficient one-pot three-component reaction for the synthesis of dithiocarbamates at room temperature under solvent- and catalyst-free conditions, starting from readily available amines, CS2 and vinyl pyridines and vinyl pyrazine is reported. Excellent yield, green reaction conditions...
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