The paper presents a combined experimental and computational study of tricarbonyl complexes fac-[Re(CO)3(L1/L2)Cl] (1a/1b) (L1 = 2-(methylthio)-N-((pyridine-2-yl)methylene)benzenamine and L2 = 2-(ethylthio)-N-((pyridine-2-yl)methylene)benzenamine). The Schiff base ligands L1 and L2 have been syn...
2-HPTP, a novel thiazolo [4, 5-b] pyridine-based Zn2+ selective fluorescent probe has been synthesized and investigated. This probe exhibited a high selectivity towards Zn2+ over other biologically essential cations such as Na+, K+, Ca2+, or Mg2+. 2-HPTP formed a 1:1 complex with Zn2+ and showed...
Angiogenesis is a hallmark in cancer. Most antiangiogenic agents block the action of vascular endothelial growth factor (VEGF). In clinic, patients develop hypoxia-mediated resistance consistent with vascular responses to these agents. Recent studies underlying such resistance revealed hypoxia-i...
We report the discovery of novel histamine H3 receptor antagonists based on 4-[(1H-imidazol-4-yl)methyl]piperidine. The most potent compounds in the series (e.g., 7) result from the attachment of a substituted aniline amide to the main pharmacophore piperidine via a two-methylene linker.
Different Lewis acids are able to promote the Friedel–Crafts reaction between 5-bromohydantoin and aromatic compounds. In the case of phenol, mixtures of ortho and para isomers are always obtained, with Mg(ClO4)2 leading to the best selectivity. However, the best overall yield of 5-(hydroxyphen...
We assessed the effect of novel selective thiopheneacetic acids on cyclooxygenase isoenzymes in vitro and in vivo. Thiopheneacetic acid Eltenac and derivatives were investigated in this study. In human whole blood experiments these derivatives were potent inhibitors of COX-2 (IC50 = 0.02–0.4 μ...
Recently, a new HPLC chiral stationary phase (CSP) prepared by covalently bonding (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid on silica gel was successfully employed in resolving various racemic natural and unnatural amino acids containing a primary amino group. Current work details on-going...
Control over the formation of N-formylamides versus the formation of captodative alkenes from the reaction of arylacetic acids with isonitriles has been achieved. Low temperatures and high concentrations favor alkenes, and high temperatures and low concentrations favor N-formylamides.
4,4′-Bis[2-(2-phenylethynyl)-3-thienyl]biphenyl, 4,4′-bis[2-{2-(trimethylsilyl)ethynyl}-3-thienyl]biphenyl and their congeners were prepared and their properties were studied. Extension of π-system through the central benzene ring was suggested by UV–vis spectra. Connection of two 1,4-bis[2-...
Reaction pathways of the gas-phase deoxygenation of propionic acid in the presence of heteropoly acid and bifunctional metal-loaded heteropoly acid catalysts were investigated in a fixed-bed reactor at 250–400 °C in flowing H2 or N2. Silica-supported H3PW12O40 (HPW) and bulk acidic salt Cs2.5H...
A vinyl group as an acetic acid side chain was attached to the optically active monoacetate of 4-cyclopentene-1,3-diol with CH2CHMgBr, LiCl, and a CuCN catalyst to produce the SN2-type product, from which the full carbon skeleton of tuberonic acid was constructed through Mitsunobu inversion, Cla...
This chapter comprises an overview on catalytic pathways to synthesize carboxylic acids using carbon dioxide as building block. After a short summary of the achievements of the past, we focus quickly on state-of-the-art protocols and look beyond in the conclusion. Certain criteria which could dr...
The objective of this study was to evaluate the influence of 4 lactic acid bacteria (LAB), Lactobacillus acidophilus, L. rhamnosus, L. casei and L. plantarum, on the flavor profile of fermented apple juice. The changes in bacterial populations, concentrations of organic acids and overall volatil...
Two new iodinated fluoro- and hydroxy-pegylated aza-diphenylacetylene derivatives, 1 and 2, targeting β-amyloid (Aβ) plaques have been successfully prepared. In vitro binding carried out in tissue homogenates prepared from postmortem AD brains with [125I]IMPY (6-iodo-2-(4′-dimethylamino)pheny...
The polymerization of diphenylacetylene derivatives possessing tert-amine moieties, such as triphenylamine, N-substituted carbazole and indole, was examined in the presence of TaCl5–n-Bu4Sn (1:2) catalyst. A polymer with high molecular weight (Mw = 570 × 103) was obtained in good yield by the ...
The reaction between diphenylacetylene and the planar chiral halogeno-bridged cyclopalladated compounds of ferrocene, [Pd{(η5-C5H3C(CH3)NNCH2CH2CH2CHCH2OCH3)Fe(η5-C5H5)}(μ-X)]2 [X=Cl: syn-(−)-(Sp,R,R,Sp)-1, syn-(−)-(Rp,R,R,Rp)-1, syn-(+)-(Rp,S,S,Rp)-1 and syn-(−)-(Sp,S,S,Sp)-1; X=Br: syn-(−...
Diphenylacetylene containing siloxy and halogen/alkyl groups (P-t-BuMe2SiO-C6H4CCC6H4-p-X, X = Cl, Br, I, Me, Et, 1b–f, respectively) were polymerized with TaCl5-n-Bu4Sn catalyst to provide high molecular weight polymers (2b–f) in good yields. These polymers afforded tough free-standing membra...
A PDPA derivative with a long alkyl side chain connected directly onto the backbone (1) was synthesized and compared to a corresponding polymer with a silylene linkage between the side chain and the backbone (2). Polymers 1 and 2 showed similar solubilities: both polymers dissolved well in organ...
Novel cylindrical polymer brushes consisting of poly(diphenylacetylene) main chain and poly(poly(ethylene glycol) methyl ether monomethacrylate) (PPEGMA) side chains were synthesized by the diphenylacetylene macromonomer or side chain initiated atom transfer radical polymerization (ATRP) of poly...
We argue that the recently reported compound 4-bromo-4′-nitrostilbene (1) is not a novel organic NLO crystal as claimed by Dinakaran, Kalainathan, Opt. Mater. 35 (2013) 898–903, but instead a well known compound whose characterization data and SHG efficiency are well documented in literature. ...
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