A mild, effective, and selective procedure is reported for the mono N-benzylation and N,N-dibenzylation of primary amines as well as mono N-benzylation of secondary amines using silica-supported copper(I) oxide in water. The silica-supported Cu2O was generated in situ by the reaction of Fehling ...
Caffeic acid derivatives are increasingly regarded as potential oncoprotective that could inhibit both the initiation and progression of cancer. Here we have synthesized seven 1-arylnaphthalene lignans and related compounds and tested their impact on breast cancer cell growth in tissue culture. ...
The decompositions of the following poly(vinyl chloride) models were investigated in the gas phase: trans-1,3-dichloro-1-pentene (in the range 310–380°), trans-5-chloro-3-heptene (296–357°), cis-4-chloro-2-pentene (295–340°) and racem, and meso 2,4-dichloropentane at 351 and 370°. The dec...
Dextromethorphan (DM) is a neuroprotective agent. The mechanism of action is believed to be by N-methyl-D-aspartate receptor blockade. The concentration of DM in the brain is believed to be dose and route dependent. Delivery by the nasal route has received a lot of attention recently, because dr...
While CYP2D6 allele and phenotype frequencies have been extensively studied, currently, very little ethnically specific data is available regarding the East African and South Pacific region, including Kenya and Vanuatu. The absence of information regarding gene polymorphisms and their resulting ...
Dextromethorphan (DM) is an antitussive with rapid acting antidepressant potential based on pharmacodynamic similarities to ketamine. Building upon our previous finding that DM produces antidepressant-like effects in the mouse forced swim test (FST), the present study aimed to establish the anti...
The over-the-counter antitussive dextromethorphan (DM) may have rapid antidepressant actions based on its overlapping pharmacology with ketamine, which has shown fast antidepressant effects but whose widespread use remains limited by problematic side effects. We have previously shown that DM pro...
Dextromethorphan which is an active ingredient in many cough medicines has been previously shown to potentiate amnesic effect of morphine in rats. However, the effect of dextromethorphan, that is also a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, in combination with morphine ...
A simple, precise, and accurate method is developed and validated for the analysis of pseudophedrine hydrochloride, dextromethorphan hydrobromide, chlorpheniramine maleate, and paracetamol in tablet formulations. The method has shown adequate separation of the four ingredients from each other. S...
In China, Poacynum hendersonii is frequently used as a substitute for Apoacynum venetum L (Luobuma), which is a famous traditional Chinese medicine. Quercetin-3-O-sophoroside and isoquercitrin are two major flavonoids in Poacynum hendersonii leaves. In this work, a suitable method was establishe...
The structures of cynanchogenin (1) and sarcostin (2) have been based on chemical and physicochemical evidence, and the correlations of lineolon (-deacylcynanchogenin; 3) with a conventional steroid is described. In 1959, the authors proposed the tentative structure (A),2 for cynanchogenin (1), ...
This article presents the data set of experimental investigation on extraction, characterization, and optimization of ethyl ester yield from sapota seed oil. The seeds were collected, dried and shells were removed. Oil was extracted by mini wooden cold press oil extraction machine and found 26% ...
Although the methanolysis of microalgae oil for biodiesel preparation was studied previously, the ethanolysis for the combined production of fatty acid ethyl esters (FAEEs, also can be used as biodiesel) and the ethyl esters of PUFAs (an important health-care product) rarely reported. In this wo...
The structure of four diterpenoid glucosides, designated as salvigresides A–D (1–4), isolated from the aerial parts of Salvia greggii, have been confirmed by spectroscopic and chemical investigation.
The conformational preferences for 2,3-O-isopropylidene-α-L-sorbopyranose derivatives 3–6 were determined by using 1H NMR data and empirical force field calculations. Proton NMR studies of 3–6 indicate that a twist-boat (or skew) conformation (3S0) prevails over possible chair forms for each ...
3-Hydroxytetradecanoic and 3-hydroxyhexadecanoic acids were used as chemical markers for the determination of lipopolysaccharides by gas chromatography-mass spectrometry of their pentafluorobenzoyl and trimethylsilyl methyl ester derivatives. The latter derivatives were simpler to prepare than t...
BackgroundTwo self-sufficient CYP102 family encoding genes (Krac_0936 and Krac_9955) from the bacterium Ktedonobacter racemifer DSM44963, which possesses one of the largest bacterial genomes, have been identified.
Rosa damascena Mill. is one of the most important plants from Rosaceae family, with a long historical use in the traditional medicine and as a valuable oil bearing plant. The rose scent derived as oil, concrete or absolute, is one of the world most sought-after products and the development of re...
The aim of the present study was to determine if the impairment in growth and weight gain observed with thiamine deficiency is associated with alterations in plasma and tissue levels of insulin-like growth factor-I (IGF-I). Male rats were fed a thiamine-deficient (TD) or pair-fed a nutritionally...
Thiamine pyrophosphate (TPP), the active form of thiamine, functions as a coenzyme for a number of enzymes involved in carbohydrate metabolism, thus making metabolites from this metabolism and keto analogues from amino and fatty acid metabolism available for the production of energy. TPP can be ...
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