BackgroundThiazolidine-2,4-dione ring system is used as a pharmacophore to build various heterocyclic compounds aimed to interact with biological targets. In the present study, benzylidene-2,4-thiazolidinedione derivatives (compounds 2–5) were synthesized and screened against cancer cell lines ...
Two slightly distorted octahedral complexes of copper(II) with (E)-2-((E)-3-(3,4,5-trimethoxyphenyl)allylidene)hydrazinecarbothioamide (L1) common name 3,4,5-trimethoxy-cinnamaldehydethiosemicarbazone and (E)-N-phenyl-2-((E)-3-(3,4,5-trimethoxyphenyl)-allylidene)hydrazinecarbothioamide (L2) comm...
BackgroundAn association between Apolipoprotein E (Apo E) alleles and genotypes and diabetic nephropathy (DN) was suggested, but with inconsistent results. We tested the relationship between serum lipids, Apo E alleles and genotypes with type 2 diabetes (T2DM), and DN pathogenesis.
12-(1H-1,2,3-Triazol-1-yl)indolo[2,1-a]isoquinolines are prepared in 51–56% yields using a PASE (pot, atom, step, economic)-based approach, namely, by the reaction between available 5-R-6-Ar-3-(isoquinolin-1-yl)-1,2,4-triazines and in situ generated benzyne. A mechanism comprising domino-transf...
Reaction of 2-hydrazino-4-methylquinoline with a series of trifluoromethyl-β-diketones gives 3-substituted-5-hydroxy-1-(4-methylquinolin-2-yl)-5-trifluoromethyl-4,5-dihydropyrazoles and, in some cases, 5-substituted-1-(4-methylquinolin-2-yl)-3-trifluoromethylpyrazoles, depending on the substitu...
Nickel(II) chloride/sodium borohydride combination was employed for the reduction of 4-hydrazinoquinoline derivatives to the corresponding anilines. This reductive protocol was efficiently applied for the reductive cleavage of monosubstituted hydrazines. We described herein the microwave-assiste...
A new hydrazone ligand, HL, was prepared by the reaction of 7-chloro-4-hydrazinoquinoline with o-hydroxybenzaldehyde. The ligand behaves as monoprotic bidentate. This was accounted for as the ligand contains a phenolic group and its hydrogen atom is reluctant to be replaced by a metal ion. The l...
Currently, available treatment options for leishmaniasis are limited and unsatisfactory. In a previous study, a quinoline derivative (AMQ-j), exhibited a strong effect against Leishmania amazonensis and its antileishmanial activity was preliminarily associated with mitochondrial dysfunction. The...
Twenty-two new hydrazones were synthesized for evaluation as possible calorimetric reagents for trace determinations of iron, cobalt, nickel, copper and zinc. Spectrophotometric studies revealed that several show promise as sensitive reagents, with possible utility for simultaneous determination...
The square planar complexes cis-[MCl2(hypy)], cis-[MCl2(hyqu)], [Pt(hypy)2] [PtCl4], [Pd(hypy)2][ClO4]2 and [Pd(hyqu)2][ClO4]2 (M = Pd or Pt, hypy = 2-hydrazinopyridine, hyqu = 8-hydrazinoquinoline), in which hypy and hyqu act as bidentate chelating ligands, have been prepared and characterized....
To regulate the effectiveness of photosynthesis and photoprotection cyanobacteria utilize a system consisting of only few components. Photoactivation of the orange carotenoid protein (OCP) enables its interaction with a specific, yet controversial site in the core of the light-harvesting antenna...
The weak photostability has to some extent restricted the wide utilization of monascus pigments in food industries, and their photobleaching mechanism is unclear yet. Density functional theory and time-dependent density functional theory at B3LYP/6-311+G(d,p) level have been performed to optimiz...
This review article summarizes recent seminal research works on optical properties of inorganic pigments. A comprehensive state-of-art on rare earth-transition metal oxide pigments brings out lacuna in the design of colorants based on systematic study of their optical properties, particle sizes ...
PD-88823, a thiomorpholine analog of prazosin, induced a consistent dose-related suppression of granulopoiesis with subsequent neutropenia and leukopenia in rats and dogs. Rats treated at 600 mg kg−1 day−1 had neutrophil counts reduced by 44% in males and 30% in females after 13 weeks. A 4-week ...
This work aims to develop a sensitive and easily applicable gold nanoparticles (AuNPs)−based colorimetric sensor for determining the propellant ammonium perchlorate (AP) in the presence of other explosives and interferents. The sensor relied on attaching methylene blue (MB), a phenothiazine dye ...
Using cesium lead halide perovskite nanocrystals, CsPb(Cl/Br)3, as a light absorber, we report a highly effective UV and blue light blocking film. The CsPb(Cl/Br)3 nanocrystals are well dispersed in the ethyl cellulose (EC) matrix to compose a UV and blue light shielding film, and the absorption...
The present study is to prepare activated carbon from Jackfruit-PPI-1 waste at 600 °C and named as JC600. Characterization of the prepared activated carbon by SEM, BET. Thermal stability of carbons was analyzed by TGA and TPD studies. Batch mode experiments were conducted to know the adsorption...
Fatty acids derived from the diet or as by-products of gut microbial metabolism can modulate immune cell function and shape gut microbiota composition, thus influencing the health status of individuals. The Western diet is qualitatively imbalanced in its fatty acid content, with a higher proport...
A new indole alkaloid, pulveratinol (1), and two new anthranilic acid derivatives (2 and 3) were isolated from Indigo Pulverata Levis, together with 12 known compounds (4–15). The structures of the new compounds (1–3) were determined through spectroscopic methods. The absolute configuration of...
The synthesis of amino-terminated anthraquinone derivatives and their incorporation onto polymer brushes for the fabrication of silicon-based nanometric functional coatings are described for the first time. The general process involves the covalent grafting of anthraquinone 1 onto two different ...
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