Rats maintained on a diet containing 0.2% DL-ethionine excreted an ultraviolet-absorbing compound in their urine that was not in the urine of rats fed the same diet without ethionine. The compound excreted was identified as S-adenosylethionine by chromatographic, spectrophometric, chemical, and ...
Publisher SummaryThis chapter discusses the reduction of sulfoxide and disulfides. The reducing system described for the reduction of L(—)-methionine sulfoxide consists of three separate enzymes designated I, II, and III. All three are essential for reaction that can be measured spectrophotomet...
N-Acetylethionine sulfoxide contained about 90% of the radioactivity excreted in the urine of control rats injected with [Et-1-14C]-ethionine. N-Acetylethionine sulfoxide was identified on the basis of its chromatography on paper with the chemically synthesized compound, its deacetylation to eth...
Two three week feeding trials tested the effects of dietary soybean trypsin inhibitors (SBTI) and/or DL-ethionine (methionine antagonist) on growth, protein digestibility, and clinical parameters in young male and female Sprague Dawley and Wistar rats. SBTI-fed rats had decreased weight gain, fe...
Ethionine is an S-ethyl analog of methionine (Met) having a small change in structure. But it is a chemical carcinogen and an antagonist of Met, thus displaying a disparate biological profile. The oxidations of ethionine by biologically important oxidants have not been exploited. Oxidations of d...
The gas-phase proton affinities (PA) and gas-phase acidities (GA) for the non-protein amino acids 1-aminocyclopropane-1-carboxylic acid (1), 1-amino-1-cyclobutane-carboxylic acid (2), cycloleucine (3) and 1-amino-1-cyclohexane (4) have been determined using the extended kinetic method in ESI-tan...
In the present paper we describe the optimization and the application of a chromatographic method suitable to get all four diastereoisomers of C24–C25 cyclopropyl dafachronic acid derivatives in sufficient amount for their biological appraisal towards the nuclear hormone receptor transcription ...
Here we report on novel and potent pyridyl-cycloalkyl-carboxylic acid inhibitors of microsomal prostaglandin E synthase-1 (PTGES). PTGES produces, as part of the prostaglandin pathway, prostaglandin E2 which is a well-known driver for pain and inflammation. This fact together with the observed u...
The Michael addition of optically active 3, 4-diphenyloxazolidinone 5 to 2′-substituted 2-chloro-2-cyclopropylideneacetates yields 2′-substituted 2-cyclopropyl-1′-(2-oxo-3, 4-diphenyloxazolidin-3-yl)acetates 6-R with excellent trans-selectivity, which upon reductive dehalogenation and subsequ...
Several lines of evidence have demonstrated the potential biomedical applications of fumaric acid (FA) and its ester derivatives against many human disease conditions. Fumaric acid esters (FAEs) have been licensed for the systemic treatment of the immune-mediated disease psoriasis. Biogen Idec I...
The synthesis of spiro[cyclopropane-1,3′-oxindole]-2-carboxylic acid, including novel 3-(2- and 3-pyridyl)-substituted analogues and the novel cyclopropa[c]quinoline-7b-carboxylic acid and their ester and amide derivatives is described. These syntheses involve diastereoselective cyclopropanatio...
An organic-salt of H4SiW12O40, (C10H7NO2)4H4SiW12O40, was prepared through the combination of H4SiW12O40 and quinaldic acid. The organic-salt was characterized by element analysis, FT-IR, UV–vis, XRD, SEM, TG, potentiometric titration and NH3-TPD. And its catalytic activity was tested in the sy...
In this study, we report for the first time the efficiency of pentafluorobenzyl bromide (PFBBr) for naphthenic acid (NA) mixtures derivatization, and the comparison in the optimal conditions to the most common NAs derivatization reagents, BF3/MeOH and N-(t-butyldimethylsilyl)-N-methyltrifluoroac...
Maleic anhydride (MAH), trans cinnamic acid (AcCin) and ethyl cinnamate (EtCin) were radically graft onto poly(butylene succinate-co-adipate) (PBSA). Samples were prepared in Brabender at 175 °C by addition of increasing amounts of MAH, AcCin, EtCin and their combinations, i.e. MAH/AcCin and MA...
Methods for the preparation of various 1-hydroxy-1,1-bisphosphonate partial esters were developed. They were obtained from (alkyl or phenyl) bis(trimethylsilyl) phosphite and aromatic or aliphatic acid chlorides, followed by methanolysis.
The synthesis of a new series of bolaform- and gemini-type phosphorus acid surfactants is described. The Pudovik addition reaction of P–H bond tetraoxyspirophosphoranes to symmetrical, prochiral bis-imines bearing different more or less long and rigid linkers occurs instantaneously at room temp...
A library of exo-cyclic carbohydrate enones 2–13 were prepared via a base-catalyzed, highly stereoselective aldol condensation of dihydrolevoglucosenone 1 (cyrene) with various aromatic aldehydes. In the case of 4-chlorobenzaldehyde as a reactant, under conditions of the aldol condensation, exo...
The hydrogen absorption of sodium intercalated fullerenes (NaxC60) was determined and compared to pure fullerenes (C60). Up to 3.5 mass% hydrogen can reversibly be absorbed in NaxC60 at 200 °C and a hydrogen pressure of 200 bar. The absorbed amount of hydrogen is significantly higher than for t...
The crystal structure of the deuteride of Ti0.85Mo0.15 alloy Ti0.85Mo0.15D1.47 is determined by neutron powder diffraction to be a tetragonally distorted fluorite-type structure similar to that of ɛ-phase in Ti–H system. The D concentration and c/a axial ratio of this phase are significantly lo...
The reliability of a recently derived potential model is tested by studying the various defect properties, such as the intrinsic defect energies (Schottky, Frenkel and antisite-pair defect energies), activation and Arrhenius energies of migration for hydrides and deutendes of lithium and sodium....
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