The effect of different concentrations of the supporting electrolyte tetraethylammonium perchlorate on the standard electrode reaction rate constants for the one-electron reduction of Eu(CF3SO3)3 on mercury in dimethylsulfoxide has been measured. Two techniques: (i) ac polarography on the droppi...
The influence of the concentration of the sodium perchlorate supporting electrolyte on the standard electrode reaction rate constants for the one-electron reduction of Eu(CF3SO3)3 on mercury in dimethylsulfoxide has been studied. The ksapp-values were derived from both ac polarography on the dro...
Potentiometric electrodes based on the incorporation of surfactant-modified zeolite Y (SMZ) particles into poly vinyl chloride (PVC) membranes were described. The electrode characteristics were evaluated regarding the response towards perchlorate ions. PVC membranes plasticized with dioctyl phth...
The densities of ammonium perchlorate, tetraalkylammonium perchlorates, R4NClO4 (R = methyl, ethyl, propyl, and butyl) and tetrabutylammonium tetraphenylborate solutions in N,N-dimethylformamide have been measured over the whole composition range at the temperatures from 283.15 K to 333.15 K. Fr...
Polymer electrolytes (PEs) have attracted attention in the last two decades due to their applications in electrochemical devices. At low temperatures, the conductivity of PEs is poor due to the presence of crystalline PEO regions. Low molecular weight liquid plasticizers and ceramic fillers are ...
2-Methoxyestradiol (2ME2) is an investigational anticancer drug. In the present study, 2-alkoxyesters/acid and 2-benzyloxy analogues of estradiol have been synthesized as analogues of 2ME2. Three of the derivatives exhibited significant anticancer activity against human breast cancer cell lines....
Herein we report the intramolecular alkylation of nitronates of methyl-5-O-benzyl-3,6-deoxy-6-nitro-β-d-glucofuranoside and methyl-5-O-benzyl-3,6-deoxy-6-nitro-α-d-glucofuranoside into the corresponding 2-oxabicyclo[2.2.1]heptane derivatives. Similarly, methyl-3-O-benzyl-5-deoxy-5-nitromethyl-...
A ring transformation of 6-methyl-7H[1], [2], [4]triazolo [4,3-b][1,2,4] triazepine-8(9H)-ones (thiones) in the presence of acetic anhydride give rise to a new series of 17 condensed 1,2,4-triazole derivatives (1-17). Plausible mechanisms are proposed and show the formation of a beta fused β-la...
A number of 1H-1,2,4-triazole alcohols containing N-(halobenzyl)piperazine carbodithioate moiety have been designed and synthesized as potent antifungal agents. In vitro bioassays against different Candida species including C. albicans, C. glabrata, C. parapsilosis, C. krusei, and C. tropicalis ...
The halogenated 1H-1,2,4-triazole glycosides 6–10 were synthesized by BF3-activated glycosylation of 3(5)-chloro-1,2,4-triazole (2), 3,5-dichloro-1,2,4-triazole (3), 3,5-dibromo-1,2,4-triazole (4), and 3(5)-bromo-5(3)-chloro-1,2,4-triazole (5) with 1,2,3,4-tetra-O-pivaloyl-β-d-xylopyranose (1)...
Some new 1H-1,2,4-triazole derivatives containing ferrocenyl moiety were synthesized in various yields by the condensation of ferrocenecarboxaldehyde with 1-(1H-1,2,4-triazol-1-yl)-3-aryl-2-one in toluene. Their structures of all these new compounds have been confirmed with 1H NMR, IR, MS and el...
A general and efficient method for the synthesis of 1-substituted 3-amino-1H-1,2,4-triazoles has been developed. The desired 3-amino-1H-1,2,4-triazoles (3) were prepared in good to excellent yields from ethyl N-(5-phenyl-1,2,4-oxadiazol-3-yl)formimidate (1a) and anilines or amines (2) via a one-...
A series of 1,3,4-thiadiazol-2-amide derivatives (5a–5y) have been designed and synthesized, and their biological activities were also evaluated as potential antiproliferation and FAK inhibitors. Among all the compounds, 5h showed the most potent activity in vitro, which inhibited the growth of...
In order to optimize the antileishmanial activity of piperazinyl-linked 5-(5-nitrofuran-2-yl)-1,3,4-thiadiazoles, we synthesized a series of 5-(5-nitrofuran-2-y1)-1,3,4-thiadiazoles with piperazinyl-linked benzamidine substituent as scaffold found in pentamidine related antiprotozoals. The struc...
Protoporphyrinogen oxidase (Protox, EC 1.3.3.4) has attracted great interest during the last decades due to its unique biochemical characteristics and biomedical significance. As a continuation of our research work on the development of new PPO inhibitors, 23 new 1,3,4-thiadiazol-2(3H)-ones bear...
The toxicity of tebuthiuron (1-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-1,3-dimethylurea) has been studied in several animal species. The acute oral LD50s in mice, rats and rabbits were 579, 644 and 286 mg/kg, respectively. In cats, oral doses of 200 mg/kg were not lethal, while 500 mg/kg given oral...
A synthesis of a novel zinc phthalocyanine with four 3-[(2-diethylamino)ethyl]-7-oxo-4-methylcoumarin dye groups at the non-peripheral positions was performed and characterized. The photophysical and photochemical properties of the peripherally (p) and non-peripherally (np) tetra-3-[(2-diethylam...
Five-membered ring systems containing two nitrogen atoms adjacent to each other are called pyrazoles. This chapter serves to cover the extensive literature on pyrazoles during the 10 year period, 1996–2006. The previous two chapters of this series, on pyrazoles, dealt more with the theoretical,...
Widespread use of commercially available palladium precatalysts is limited by high costs and their synthetic challenges. In this report, series of synthetically affordable, phosphine-free ligands were examined as supports for palladium active centers. 2-(2-Aminoethylamino)ethanol, diethylenetria...
Sulfonyloxyl radicals, readily generated upon UV irradiation of p-pyridine sulfonyl ethanone oxime derivatives, effectively cleave DNA, in a pH independent manner, and under either aerobic or anaerobic conditions. p-Pyridine sulfonyl ethanone oxime derivatives were synthesized from the reaction ...
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