In our search for natural human carboxylesterase 2 (hCE 2) inhibitors from natural products, we investigated inhibitory effects and mechanisms of flavonoids (1–16) against hCE 2. The results demonstrated that kurarinone (1), baicalein (2), 2-[(2′-(1-hydroxy-1-methylethyl)-7′-(3-methyl-2-buten...

Hybrid films composed of electropolymerized luminol–flavin adenine dinucleotide (FAD) adsorbed film modified electrodes have been prepared in aqueous acidic solutions. These films are stable and electrochemically active, and can be produced on glassy carbon, platinum, gold, and transparent semi...

Flavin adenine dinucleotide (FAD)-modified zinc oxide self-assembly films were prepared using repeated cyclic voltammetry. The electrochemical reaction of the hemoglobin with the FAD/ZnO self-assembly film-modified electrodes and their electrocatalytic properties were investigated. This paper de...

Six FAD-dependent glucose dehydrogenase (FAD-GDH) genes, for blood glucose sensors, from the genomic DNAs of Aspergillus species were identified by degenerated PCR screening. The enzymatic properties of the gene products expressed by Pichia pastoris were characterized. Investigation of substrate...

The flavin adenine dinucleotide (FAD) modified zinc oxide films have been prepared using repeated cyclic voltammetry to investigate both the deposition process and the films’ electrocatalytic properties. This paper describes the successful loading of electrochemically active molecules into ZnO ...

Various nutritional signals are transduced by two epigenetic pathways: NAD-dependent sirtuin Sirt1 (NAD+-Sirt1) deacetylase and flavin adenine dinucleotide–dependent lysine-specific demethylase 1 (FAD-LSD1). These pathways are controlled by dietary vitamins and nutrient-responsive hormones such...

There is growing evidence of reciprocal interactions between the endogenous circadian clock and subcellular redox pathways. Recently, researchers at the University of California unearthed another possible link between redox metabolism and the mammalian circadian clock: the redox cofactor FAD sta...

FAD-dependent glucose dehydrogenase (FAD-GDH, EC 1.1.5.9) is an enzyme utilized industrially in glucose sensors. Previously, FAD-GDH isolated from Mucor prainii (MpGDH) was demonstrated to have high substrate specificity for glucose. However, MpGDH displays poor thermostability and is inactivate...

It is very meaningful and useful to select specific aptamers with capacity to distinguish small structural analogues, but it is difficult to carry out by traditional affinity chromatography-SELEX (systematic evolution of ligands by exponential enrichment) based on immobilized target molecules. I...

Fish aggregating devices (FADs) have over recent decades, become an integral tool in commercial tuna fisheries due to their increased efficiency over free school catches. Technological development has further aided in their increased usage and reliance by many fleets. The negative consequences o...

The photodecomposition of new 1,4-dihydropyridine, furnidipine (CRE-319); 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropy-ridine-3,5-dicarboxylic acid 3-tetrahydrofurfuryl (5-methyl diester) was studied by voltammetric, UV-vis spectrophotometric, and HPLC technique with three different light condit...

The four stereoisomers of methyl tetrahydrofuran-2-ylmethyl 2,6-dimethyl-4-(o-nitrophenyl)-1,4-dihydro-pyridine-3,5-dicarboxilate (furnidipine), have been synthesized and separated by chiral chromatography using D-phenylglycine as chiral stationary phase. Enantiomeric purity of stereoisomers is ...

Inclusion complexation between furnidipine (2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-tetrahydrofurfuryl 5-methyl diester), a calcium-channel antagonist, and β-cyclodextrin (β-CyD) was studied in aqueous solution by using both spectrophotometric and electrochem...

Protective effects of acute oral or intravenous doses of furnidipine against ischemia and re-perfusion-induced arrhythmias and creatine kinase release were studied in a rat model for cardiac ischemia and re-perfusion. Transient cardiac ischemia was induced by occluding the left coronary descendi...

1,4,-dihydropyridines, belonging to the class of “privileged structures”, are known to protect the heart from stunning, ischemia and ventricular arrhythmias and mainly used in hypertension. The aim of this study was to compare the continuous infusion of parent drug, furnidipine, with its two a...

Hydrogels were prepared by photoinduced polymerization of poly(ethylene glycol)monoacrylate (PEGMA) and poly(ethylene glycol)diacrylate (n = 200 and 700) (PEGDA) with Type I, 1-[4-(2-hydroxyethoxy)-phenyl]-2-hydroxy-2-methyl-1-propane-1-one (I-2959) and one-component Type II initiators: (9-oxo-9...

Thioxanthonation of diphenyl units of diphenyl disulfide was achieved successfully. The photoreduction and photostabilization ability of 2, 2′-disulfanediylbis (9H-thioxanthen-9-one) was used for in-situ preparation of Au nanoparticles either in solution or in poly(ethylene glycol) methyl ether...

A new chromium carbon paste electrode sensor based on a carbon paste electrode containing 1-[(2-hydroxy ethyl) amino]-4-methyl-9H-thioxanthen-9-one (AMTX) as new carrier has been prepared. The influence of carbon paste ingredients including sodium tetraphenylborate (NaTPB), ionophore, Nujol and ...

Camellia-oil based oleogels were structured at a constant tea polyphenol-palmitate (Tp-palmitate) particles concentration of 2.5% (m/v) and varying citrus pectin concentration of 1.5, 2.5, 3.5 and 4.5% (m/v) using emulsion-templated method. Optical and laser confocal microscope were used to obse...

Metabolic profiling studies have highlighted increases in the plasma free fatty acid (FFA) and branched-chain amino acid (BCAA) concentrations, which are hallmarks of the obese and insulin-resistant phenotype. However, little is known about how the increase of the BCAA concentration modifies the...