1.1. The nature of the inhibitory effect of Bayluscide, sodium pentachlorophenate, and copper sulphate on succinate oxidation in tissue homogenates of the snail, Biomphalaria alexandrina, is investigated.2.2. Evidence indicates that the inhibition caused by sodium pentachlorophenate (5 × 10−5M)...
In this study, the adsorption kinetics of sodium pentachlorophenate (PCP-Na) onto multi-walled carbon nanotubes (MWCNTs) was determined and acute toxicity tests were performed to evaluate the toxicity of MWCNTs and PCP-Na on the earthworm Eisenia fetida in artificial soil samples, and then the t...
The radical translocation reactions in N,N-disubstituted acetamides 10a, 14a–d and trifluoroacetamides 10b, 14e–f have been studied by deuteration experiments with n-Bu3SnD. The intramolecular hydrogen atom transfer from the N-alkyl side chain to the aryl radical takes place through competing ...
A simple method has been developed for the efficient synthesis of naphtho[b]furans from allyl bromonaphthyl ethers. The approach utilizes a novel photochemical process involving sequential radical cyclization and dehydrohalogenation. Because light is a readily available, environmentally friendly...
The first successful synthesis of 1H-2,3-benzoxazine 3-oxides has been described. The efficiency of the approach is provided by the C–C-coupling of 2-(2-bromoaryl)cyclopropane-1,1-dicarboxylates with primary nitroalkanes catalyzed by Pd(dba)2/JohnPhos system followed by in situ recyclization of...
Novel 4-alkyl-3-aryl-2,6-dicyanoanilines were synthesized by a multi-component one-step reaction of aromatic aldehyde, malononitrile and aliphatic aldehyde using tris(hydroxymethyl)aminomethane (THAM) as a catalyst under microwave (MW) irradiation or conventional heating. The optimized reaction ...
A versatile and highly diastereoselective four-step approach to (4S,5R)-N-benzyl-4-benzyloxy-5-(α-hydroxyalkyl)-2-pyrrolidinones 2, which starts from readily available (S)-N,O-dibenzylmalimide (5), is reported. Substituted 2-pyrrolidinones 2 are valuable building blocks for the asymmetric synth...
Poly(5-hydroxy-trimethylene carbonate) (PHTMC) was synthesized through ring-opening polymerization of 5-benzyloxy trimethylene carbonate followed by debenzylation. The water solubility of the resulting homopolymer was measured as a function of its molecular weight, and its degradation in acidic ...
A series of novel substituted pyridyl phenyl oxazolidinone analogues were synthesized and their structure–activity relationship (SAR) was investigated based on in vitro and in vivo antibacterial activities. The minimum inhibitory concentrations (MICs) of the synthesized compounds against methic...
We report the synthesis of 5′-modified thymidines (16, 18, 21, 23) and 5,5′-bis-substituted 2′-deoxyuridine analogues (30, 47) as inhibitors of thymidine monophosphate kinase of Mycobacterium tuberculosis (TMPKmt). These analogues were evaluated for their capacity to inhibit TMPKmt and solely...
The kinetics of Ir(III)-catalyzed oxidation of d-fructose by potassium iodate was studied in an aqueous alkaline medium at 40 °C. The experimental result shows a first order dependence on iodate and [OH−] at their low concentrations, but tending towards zeroth order at their higher concentratio...
Xanthobilirubic acid and its analogs self-associate strongly through intermolecular hydrogen bonding between their carboxylic acid and dipyrrinone components, forming π-stacked dimers. In contrast, their methyl esters form planar dimers conjoined by dipyrrinone to dipyrrinone intermolecular hyd...
Synthesis of the novel selenium heterocycles 1, 2, and 3 based on the addition reaction of selenium dibromide to divinyl sulfide is described. The reaction proceeded in CCl4 at room temperature to give the thiaselenane 1. Even at low temperature in chloroform solution, the 6-membered thiaselenan...
Highly functionalized 5-bromo-2-amino-1,3-thiazoles bearing various substituents could be easily prepared by a rapid and efficient one-pot method, using simple starting materials and mild conditions while avoiding the use of metal catalysts or inconvenient reagents such as elemental halogens. Th...
Polypropylene (PP) films grafted with N-isopropylacrylamide (NIPAAm) and N-(3-aminopropyl) methacrylamide hydrochloride (APMA) were tested as components of medical devices able to load and to sustain the release of the antimicrobial agent nalidixic acid. A pre-irradiation method was applied for ...
ABSTRACTThe relationship of high and low molecular weight mannuronic acid (M)- and guluronic acid (G)-rich alginate nanoparticles as oral insulin carrier was elucidated. Nanoparticles were prepared through ionotropic gelation using Ca2 +, and then in vitro physicochemical attributes and in vivo ...
Guluronic acid oligosaccharides (GOS) with degree of polymerization (DP) ranging from 1 to 10 were prepared by a rapid microwave degradation method. Polyguluronic acid, fractionated from alginate hydrolysate, was dissolved in dilute ammonia water at a concentration of 20 mg/mL (pH 5) and then hy...
BackgroundAging is usually associated with increased levels of oxidants, and may result in damages caused by oxidative stress. There is a direct relationship between aging and increased incidence of inflammatory diseases. The present research intended to study the anti-aging and anti-inflammator...
Cancer-related inflammation (CRI) is associated with the malignant progression of several cancer types. Targeting these pathways is a novel promising strategy for cancer prevention and treatment. In this present study, we evaluated the efficacy of α-l-guluronic acid (ALG), a potent anti-inflamm...
Alginate is an anionic polysaccharide capable of forming insoluble particles with proteins. Hence, alginate has potential as a protein carrier. However, the role of physical properties of the polysaccharide, such as degree of polymerization (DPn) and mannuronic/guluronic acid ratio, remains to b...
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