Amino acids are simple organic compounds that contain one or more amino groups and one or more carboxyl groups. They are the building blocks of peptides, proteins, and components of other complex polymers like the cell wall. There are 20 protein-forming amino acids, all of which, except glycine,...
Face-selective 1,6-addition of lithiated Schöllkopf's bislactime ether 5 to 4-substituted, 1,4- or 3,4-disubstituted 1E,3E-butadienylphosphonates6a-d allows a direct and stereocontrolled access to semi-rigid AP6 analogues, the 2,3-anti-4E 2-amino-6-phosphono-4-hexenoic acid derivatives 4a-c...
In this study we explored, for the first time, the lactic acid fermentation of elderberry juice (EJ). A total of 15 strains isolated from dairy and plant matrices, belonging to L. plantarum, L. rhamnosus and L. casei, were used for fermentations. The volatile profile of started and unstarted EJ ...
The human immunodeficiency virus-type 1 (HIV-1) reverse transcriptase (RT) is a multifunctional enzyme which displays DNA polymerase activity, which recognizes RNA and DNA templates, and a degradative ribonuclease H (RNase H) activity. While both RT functions are required for retroviral replicat...
In search of new immunosuppressants we synthesized 11 amino acids derivatives of MPA as methyl esters 10a–k using EDCI/DMAP and their corresponding amino acid derivatives in free acid form 11a–k by hydrolysis of ester group with LiOH/MeOH. New analogs were evaluated as growth inhibitors of lym...
SummaryPlastics, used in countless consumer products that our daily lives depend on, have become indispensable materials essential for modern life and the global economy. At the same time, currently unsustainable practices in the production and disposal of plastics continue to deplete our finite...
Asymmetric hydrogenation of prochiral keto groups with (S,S) and (R,R)- SkewphosRuBr2 prepared in situ is described. Good enantiomeric excesses up to 95% were obtained.
The influence of functional group Q on course and rate of the reaction of 3-B, 3-C, 3-Si, 3-Sn, 3-N, 3-P, 3-O, 3-S, 3-Se, 3-Cl, 3-Br, and 3-I substituted allylic systems of type Q–CH2CHCH2 with hydride ruthenium complexes (primarily [RuClH(CO)(PPh3)3]) has been researched. It has been proved th...
A simplified procedure of enantioselective ruthenium-catalyzed hydrogenation of functionalized ketones using commercially available [RuCl2(COD)]n, (COD = cis,cis-cycloocta-1,5 diene) mixed with the chiral diphosphines (BINAP, MeO-BIPHEP, DuPHOS) is reported. Under these conditions, C-O groups we...
2-chloro-3-keto esters were quantitatively hydrogenated to syn and anti 2-chloro-3-hydroxyester by asymmetric hydrogenation with chiral ruthenium (II) catalysis prepared in-situ from (COD)Ru(2-Methylallyl)2 in presence of atropisomeric ligands such as MeO-Biphep and Binap, giving enantioselectiv...
New chiral oxazoline-based ruthenium(II) complexes have been synthetized and fully characterised. The corresponding grafted catalysts were prepared by anchoring the complexes onto SiO2 or Pd/SiO2 supports. 13C CP-MAS NMR and XPS spectroscopies showed that the organometallic complexes remained un...
Two amino-acids derived from pipecolic acid have been isolated from leaves of Derris elliptica. Their structure was confirmed by synthesis. They are: 2S-carboxy-4R,5S-dihydroxypiperidine and 2S-carboxy-4S,5S-dihydroxypiperidine.
In this present work, first time interaction between new synthesized derivative of the 4-((E)-((4-((E)-phenyldiazenyl)phenyl)imino)methyl)benzoic acid (E-PABA) and the BN(6,6-7) Nanotube for medical applications were studied. The geometries of the compounds E-PABA, the BN(6,6-7) Nanotube and the...
A series of aryl azo derivatives of naphthols (1–3) were studied by means of UV–Vis and NMR spectroscopy in different solvents as well as by quantum chemical calculations and X-ray analysis. Previous studies have shown that Sudan I (1) exists as a tautomeric mixture. The effect of the solvents...
The Schiff base compounds 2-((4-amino-1,2,5-oxadiazol-3-ylimino)methyl)-4-(phenyldiazenyl) phenol (2a–e) were prepared from the reaction of 3,4-diamino-1,2,5-oxadiazole with 2-hydroxy-5-[(E)-(aryldiazenyl)]benzaldehyde (1a–e) in methanol. The structures of all compounds were then characterized...
The crystal and molecular structures of 6-methyl-3,5-dinitro-2-[(E)-phenyldiazenyl]pyridine have been determined by X-ray diffraction and quantum chemical DFT calculations. The crystal is monoclinic, space group Cc (No. 9) with Z = 4 with the unit cell parameters: a = 12.083(7), b = 12.881(6), c...
In situ spectroelectrochemical detection of reaction intermediates was used as a decisive method for elucidation of a rather complex redox mechanism of azoquinoline dye 2-methyl-5-[(E)-phenyldiazenyl]quinolin-8-ol (R-N=N-Ph; where Ph = phenyl, R = 2-methyl-8-hydroxyquinoline fragment). Electroch...
The solubility of levamisole hydrochloride (LH) in binary {methanol (MT) + ethanol (EA), methanol (MT) + 2-propanol (IPA)} solvent mixtures from 283.15 K to 323.15 K and dimethyl sulfoxide (DMSO) + ethanol (EA) from 293.15 K to 333.15 K were obtained under the pressure of 0.1MPa by using a dynam...
Carbamazepine (CBZ) is one of the most frequently detected pharmaceuticals in the aquatic environment. In the human body, CBZ is metabolized and transformed into a variety of metabolites. Among metabolites, CBZ N-glucuronide (CBZ-Glu, Phase II metabolite) was discharged into sewage system togeth...
A kinetic model is proposed for modeling the time-course conversions of lipase-catalyzed hydrolytic resolution of (R,S)-N-Cbz-proline 1,2,4-triazolide (1) and (R,S)-N-Cbz-pipecolic 1,2,4-triazolide (2) in water-saturated MTBE at 45 °C, in which effects of non-enantioselective hydrolysis from ac...
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