The NRPS/PKS cluster encodes the enzymes necessary for glidobactin synthesis it is partially conserved in various members of the Burkholderia genus including B. pseudomallei. In this study we have shown that the insertional inactivation or deletion of glbC in this cluster in B. pseudomallei coul...
SummaryGlidobactins are hybrid NRPS-PKS natural products that function as irreversible proteasome inhibitors. A variety of medium chain 2(E),4(E)-diene fatty acids N-acylate the peptidolactam core and contribute significantly to the potency of proteasome inhibition. We have expressed the initiat...
Syrbactins are cyclic peptide derivatives which are known to inhibit the eukaryotic proteasome by irreversible covalent binding to its catalytic sites. The only two members of this family characterized to date, syringolin A and glidobactin A, are secreted by certain strains of Pseudomonas syring...
[Polyangium] brachysporum DSM7029 can produce glidobactin, which is a peptide-based proteasome inhibitor that shows great potential as an anticancer drug. To better understand the glidobactin biosynthesis mechanism and to aid further studies of this strain, we report the annotated complete genom...
Disseminated Nocardia caviae infection occurs only rarely. To date, two cases have been recorded in the literature. We describe a third case of systemic N. caviae infection in a compromised host and compare it with the first two cases. Postmortem, microbiologie and antibiotic sensitivity data ar...
An 11 year old child presented with extensive involvement of the right mandible due to Nocardia pelletieri. Medical treatment, consisting of sulfadiazine and alternating courses of neomycin and tetracycline, was successful with no evidence or reactivation during 5 years of posttreatment follow-u...
PurposeTo analyze the clinical presentation, microbiological profile, and treatment outcome in cases of nocardial endophthalmitis after cataract surgery.
Experimental infection of BALB/c mice with the Gram-positive bacterium Nocardia asteroides (strain GUH-2) results in life-long movement abnormalities including head shaking and spinning when held by the tail. The head shaking is temporarily inhibited by treatment with dopamine's precursor l...
We present the first case of lymphocutaneous nocardiosis caused by Nocardia transvalensis and the seventh report of infection caused by this microorganism. The patient was allergic to sulfonamides but responded to amikacin and cefotaxime and later to erythromycin. The treatment and criteria for ...
Publisher SummaryActinomyces are Gram-positive, pleiomorphic, often filamentous, rod-shaped bacteria belonging to the family Actinomycetales. Morphologically, many species resemble nocardioform actinomycetes whereas others are more coryneform. Most Actinomyces species are parasitic and represent...
Nocardia are aerobic, gram-positive, nonmotile and branching filamentous bacteria. Corneal infection by Nocardia is rare. Trauma is the most common predisposing factor. Isolated case reports of nocardial infection associated with contact lens wear and laser in situ keratomileusis (LASIK) have be...
Nocardia seriolae infection is one of the most serious bacterial diseases in Seriola species in Japanese aquaculture. In this study, the combination effect of N-acetyl-d-glucosamine (NAG) with oral oxytetracycline (OTC) treatment was evaluated with the experimental infection of artificially bred...
A rubber-degrading bacterial consortium named H2DA was obtained from an enrichment culture with natural rubber latex and rubber-processing factory waste in Vietnam. Gel permeation chromatography analysis revealed that only the strain NVL3 degraded synthetic poly(cis-1,4-isoprene) into low-molecu...
Nocardiosis is an opportunistic infectious disease caused by a ubiquitous aerobic bacterium of the genus Nocardia that can be found in the environment. These intracellular bacteria are held responsible for many infections affecting the lungs, the brain or the skin, especially in immunocompromise...
Mulundocandin (1), is an echinocandin class of lipopeptide. It has wide spectrum of antifungal activity against Candida and Aspergillus species. Semisynthetic modification at Ornithine-5-hydroxyl (hemiaminal function) of 1 was carried out to improve solution stability and hence in vivo activity....
Semisynthetic modifications at Hydroxy tyrosine (Htyr) unit of mulundocandin (1) were carried out to improve its aqueous solubility. A single step introduction of substituted aminomethyl groups at the ortho position(s) of phenolic hydroxyl of HTyr unit of mulundocandin has been achieved in 7–85...
Semisynthetic modifications at position-12 (ornithine-5-position, hemiaminal function) of mulundocandin were carried out to improve its chemical stability. New carbon–carbon (C–C) and carbon–hydrogen (C–H) linkage at hemiaminal function -12 has been achieved. Lewis acid catalyzed introductio...
Synthesis of four derivatives of symmetrical aza[7]helicenes is achieved by I2-THF mediated photocyclization of corresponding bis-styryl derivatives. The cyclization furnished the desired angularly fused aza-helicene in moderate yields. The structures are established by NMR spectroscopy and sing...
Rice is a staple food in many countries around the world and it is a source of not only the nutrients, but also toxic elements. In this study, we evaluated four degrees of polishing and determined the elemental content (P, S, K, Mn, Fe, Ni, Cu, Zn, As, Se, Mo, Cd, Hg, Pb) in brown rice, rice bra...
Brown diseases comprise disorders leading to hyperpigmentation in skin and nail. Melasma is an acquired skin disorder that is characterized by brownish macules that typically occurs on the face. Schamberg’s disease, also known as progressive pigmented purpura, is characterized by brown pigmenta...
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