Bacteria remain a great threat to human health. In the present study, we examined whether sonodynamic action of chlorin e6 had antibacterial activity on gram-positive bacterial strain Staphylococcus aureus (S. aureus) and gram-negative bacterial strain Escherichia coli (E. coli). Colony forming ...

BackgroundPhotodynamic therapy (PDT) exploits the reaction between photosensitizer and irradiated light to generate potentially therapeutic reactive oxygen species such as singlet oxygen in cancer cells. We have reported several sugar-conjugated chlorins that express stronger antitumor effects i...

In order to increase the photodynamic effect of Chlorin e6, four Chlorin e6-artesunate conjugates were designed and synthesized. Among them, three conjugates (3, 6, 9) contained single artesunate side chain at 152, 173 and 131 of Chlorin e6, respectively, and one conjugate (11) contained three a...

Photodynamic therapy (PDT) is a novel and non-invasive treatment that induces apoptosis and autophagy. Autophagy could play a pro-survival role, thus inhibiting autophagic activity might be a promising method to enhance the effectiveness of PDT for tumors. In the present study, photosensitizer C...

We synthesized new hydrophilic chlorin e6 derivatives with two and four galactose fragments conjugated to the macrocycle via carbon atom in position 6 of the galactose fragment. Galactose fragments were inserted by alkylation of the amino groups of chlorin e6 amides with one and two ethylene dia...

Bacterial infections are a growing global challenge for public health as antibiotic resistance could cause the failure of anti-infective treatment eventually. So, it is urgent to develop new potential antibacterial materials. Herein, a multifunctional chitosan (CS) functionalized magnetic Chlori...

In the study we have reported the physico-chemical, photophysical and morphological properties of chlorin e6 (Ce6) decorated doxorubicin (DOX) encapsulated chitosan (CS)-tripolyphosphate (TPP) nanoparticles which prepared by ionotropic gelation method. The Ce6 physically loaded onto the nanopart...

Aedes aegypti mosquitos are widespread vectors of several diseases and their control is of primary importance for biological and environmental reasons, and novel safe insecticides are highly desirable. An eco-friendly photosensitizing magnetic nanocarrier with larvicidal effects on Aedes aegypti...

The aim of the present study is to fabricate hydrogel as a photosensitizer (PS) for photodynamic therapy. Chlorin e6 (Ce6)-fucoidan/[email protected] gum (Ce6-Fu/[email protected])-based hydrogel was fabricated and characterised in terms of morphology and functional groups. MTT assay was used to...

The thermal stability and degradation behaviour of poly(2-bromoethyl methacrylate (PBEMA), poly(2,3-dibromopropyl methacrylate) (PDBPMA), poly(methyl-α-bromoacrylate) (PMBA) and their copolymers have been investigated by thermogravimetric analysis in nitrogen and rapid pyrolysis in helium. Both...

Radical copolymerizations of methyl α-bromoacrylate, 2-bromoethyl methacrylate and 2,3-dibromopropyl methacrylate with vinyl triacetoxysilane (VTAS) were carried out in bulk at 60 ± 0.1° using azobisisobutyronitrile as initiator. The compositions of low conversion copolymers were determined b...

The products of degradation of blends of poly(2,3-dibromopropyl methacrylate) and poly(2,3-dibromopropyl acrylate) with poly(methyl methacrylate) and poly(methyl acrylate) are predominantly those to be expected from the degradation of the individual polymers. However, the appearance of methyl br...

The products of the thermal degradation of poly(2,3-dibromopropyl methacrylate) and poly(2,3-dibromopropyl acrylate) have been analysed quantitatively using thermal analysis, infra-red spectroscopy, mass spectrometry and gas-liquid chromatography. Monomer is the principal product from the former...

The products of the thermal degradation of copolymers of methyl methacrylate with 2,3-dibromopropyl methacrylate and 2,3-dibromopropyl acrylate have been analysed quantitatively using thermal analysis, infra-red spectroscopy, mass spectrometry and gas-liquid chromatography. Many of these product...

The products of the thermal degradation of copolymers of styrene (S) with 2,3-dibromopropyl methacrylate (2,3-DBPM) and 2,3-dibromopropyl acrylate (2,3-DBPA) have been analysed quantitatively using thermal analysis, infra-red spectroscopy, mass spectrometry and gas-liquid chromatography. The pro...

The products of the thermal degradation of copolymers of methyl acrylate (MA) with 2,3-dibromopropyl methacrylate (2,3-DBPM) and 2,3-dibromopropyl acrylate (2,3-DBPA) have been analysed quantitatively using thermal analysis, infra-red spectroscopy, mass spectrometry and gas-liquid chromatography...

The saturated solubilities of DL- Tyrosine, DL-Leucine, DL-Isoleucine and DL-Threonine in binary aqueous dipolar aprotic acetonitrile solvent were estimated by ‘formol titrimetry’ at nine equidistant temperatures under 0.1MPa pressure. The chemical effects of the standard transfer energetics o...

Reaction of 2-alkynylbenzaldoximes 1 with 5 equiv of iodine in EtOH at room temperature gives the corresponding iodoisoquinoline N-oxides 2 in good to excellent yields. The cyclization proceeds very smoothly and quickly without any additives such as bases under very mild reaction conditions.

The reaction of 1-(dichloromethyl)-5-nitroisoquinoline with 2-nitropropane anion which gives 1-isopropylidenemethyl-5-nitroisoquinoline as major product is shown to proceed by the consecutive SRN1 and ERC1 mechanisms. These mechanisms are confirmed by the inhibitory effects of dioxygen, p-dinitr...

A Lewis acid-catalyzed [3+1+1] cycloaddition reaction between aliphatic isocyanides and azomethine ylides generated in situ from aziridines, leading to pyrrolidine derivatives, has been developed. This reaction proceeds smoothly under mild conditions and can also be modified by employing aromati...