Arg-conopressin-S and Lys-conopressin-G are cyclic disulphide-bridged nonapeptides isolated from the venom of cone snails. We performed a comprehensive conformational analysis for the cis and trans isomers of these conopeptides, in order to identify their characteristic structural and conformati...

Increased understanding of the molecular components involved in mollusc reproduction may assist in understanding the evolutionary adaptations used by animals, including hermaphrodites, to produce offspring. The neuropeptide conopressin, a member of the vasopressin/oxytocin-like peptide family, c...

Crystals of l-tyrosine and semiorganic l-tyrosine hydrochloride and l-tyrosine hydrobromide, known for their nonlinear optical properties, were studied by Raman spectroscopy in the temperature range from 298 to 453 K. Hydrogen bonding at room temperature and thermal decomposition are correlated ...

ABSTRACTGlassy states of nine acetaminophen–nifedipine compositions have been made by slowly supercooling their melts, and calorimetric Tg and the nonexponential, nonlinear relaxation parameters β and x that are used in modeling the mobility of a pharmaceutical determined. The Tg-endotherm...

BackgroundThe aims of this work were to enhance the solubility of nifedipine in acidic medium; to formulate and characterize tab-in-tab dosage form for immediate release of nifedipine and controlled release of ramipril and to avoid the mutual interactions of drugs. This combination appreciably i...

The last decade has seen continued development and refinement of guidance related to mutagenic impurities (MIs); culminating in June 2014 with the publication of ICH M7. This has seen an introduction of factors such as durationally adjusted limits and emergence of alternative approaches to demon...

Crystallization in the presence of Polysorbate-80 (T-80), a non-ionic surfactant was explored for crystal habit modification of nifedipine polymorph I (Nif). A concentration dependent reduction in aspect ratio was observed with T-80. Generation of any new solvates/polymorphs was ruled out by Fou...

The polymorphic behaviour of nifedipine was investigated using differential scanning calorimetry (DSC), modulated temperature DSC (MTDSC) and hot stage microscopy (HSM). DSC and MTDSC scans of glassy nifedipine samples revealed the presence of several heating rate-dependent events occurring prio...

Nifedipine and atenolol dugs are conjugated in several anti-hypertensive pharmaceutical formulations. Herein, a reproducible and sensitive voltammetric procedure has been developed for the simultaneous analysis of nifedipine and atenolol for the first time using MgO − nanoplatelets modified scre...

Steroid hormones that are controlled by steroidogenic acute regulatory (StAR) gene regulate sperm production. However, calcium ion is important for male fertility in vasodilation and sperm development. Calcium also serves as a second messenger to control acrosome reaction and sperm motility. Cal...

In this work, strontium cerate nanoparticles (SrCeO3 NPs, SC NPs) were developed through facile synthetic techniques (Ultrasound-Assisted (UA) and Stirring-Assisted (SA) synthesis) and utilized as an electrocatalyst for the selective and sensitive electrochemical detection of calcium channel blo...

This article introduced the work of ethylcellulose based polymeric microsphere loaded with nifedipine for reduction in frequency of administration with low solubility in aqueous medium and high rate of absorption in the stomach. The non-aqueous polymeric suspension was put dropwise into an aqueo...

In this work, various new nano-alkalinecellulose carboxylates (NACCs) were prepared by oxidative hydrolysis of microalkalinecellulose (MACp) given from prewashed cotton. After the optimization of the reaction time, temperature, oxidant system, and oxidant loading, the new flake-shape anionic NAC...

6-Azacholest-4-en-3β-ol-7-one (azacholesterol) was shown to be a specific inhibitor of cholesterol 7α-hydroxylase. It inhibited cholesterol hydroxylation by a rat liver microsomal preparation with non-competitive kinetics and a Ki of 4 μM. No evidence was found for a time-dependent inhibition...

The effects of 6,6-difluorcholestanol and 7,7-difluorocholestanol on enzymes of hepatic liver cholesterol were examined. Neither compound affected the activity of 3-hydroxy-3-methylglutaryl-CoA reductase. 7,7-Difluorocholestanol had no effect on the activity of acyl-CoA: cholesterol acyltransfer...

This paper describes the effect of thiophenol concentration on photochemical rearrangement of 2-phenylthio-3-aminocyclohexanols to the corresponding protected aminoaldehydes. The obtained aminoaldehyde is in equilibrium with its corresponding deoxyazasugar. The latter could be converted to the c...

The present review lists the papers and patents dealing with the class of polycondensed heterocycles called benzopyrroloxazines published in the last decades. The survey is limited to substances characterized by the presence of a bridgehead N atom, which means that the present N atom serves to c...

The synthesis of indolo[3,2-b]carbazole-based mono- and dihydrazones with reactive vinylbenzyl or vinyloxyethyl functional groups at the nitrogen atom of hydrazine moiety is reported. The thermal, optical, photophysical, electrochemical and photoelectrical properties of the synthesized compounds...

Four novel indolo[3,2-b]carbazole-based multi-donor–π–acceptor type organic dyes QX01–04 have been designed, synthesized, and applied for dye-sensitized solar cells. These dyes consist of an indolo[3,2-b]carbazole core acting as the main donor group, a couple of groups such as ethylbenzene, ...

A variety of hallucinogens of the lysergamide type has emerged on the drug market in recent years and one such uncontrolled derivative of lysergic acid diethylamide (LSD) is 1-propionyl-LSD (1P-LSD). Due to the high potency of LSD and some of its derivatives (common doses: 50–200 μg), sensitiv...