ResumoJustificativa e objetivosO alívio inadequado da dor após a reconstrução do ligamento cruzado anterior afeta a mobilidade, leva ao desenvolvimento de aderências, inserção do ligamento enfraquecido e atrofia muscular. O bloqueio do canal adutor para analgesia pós‐operatória preserva a ...

This paper describes the frequentist and Bayesian estimation for the scale parameter λ and shape parameter β of the inverse Weibull (IW) distribution based on adaptive type-II progressive hybrid censoring scheme (AT-II PHCS). We discuss the maximum likelihood estimators (MLEs) and the approxim...

In reliability and life testing experiments, the censoring scheme which can balance between the total time spent for the experiment, the number of units used and the efficiency of statistical inference based on the results of the experiment is desirable. An adaptive Type-II progressive censoring...

The adaptive cycle and its extension to panarchy (nested adaptive cycles) has been a useful metaphor and conceptual model for understanding long-term dynamics of change in ecological and social–ecological systems. We argue that adaptive cycles are ubiquitous in complex adaptive systems because ...

In this paper, the estimation problem (point and interval) is studied under the exponentiated exponential (EE) distribution based on an adaptive progressive type-II censoring scheme. In point estimation, the maximum likelihood estimates (MLE′s) and Bayes estimates (BE′s), based on squared erro...

Given their intrinsic features, adaptive facades are required to satisfy rigid structural performances, in addition to typical insulation, thermal and energy requirements. These include a minimum of safety and serviceability levels under ordinary design loads, durability, robustness, fire resist...

In this paper, the problem of estimating parameters of the inverted exponentiated Rayleigh distribution under adaptive Type II progressive hybrid censored sample is discussed. The maximum likelihood estimators (MLEs) are developed for estimating the unknown parameters. The asymptotic normality o...

Cadmium (Cd) can cause the deterioration of biological systems through inhibiting the enzymes activity and disturbing the microbial metabolism. Although the influence of Cd on conventional wastewater treatment process has been studied, the response of anammox to Cd exposure still remains unclear...

Intestinal epithelial cells (IECs) form a fundamental mucosal barrier and actively participate in tolerance and immunity against intestinal contents. Major histocompatibility complex class II (MHC II) and invariant chain (Ii) molecules are essential for adaptive immune response. MHC II deficienc...

SummaryPhase II clinical studies represent a critical point in determining drug costs, and phase II is a poor predictor of drug success: >30% of drugs entering phase II studies fail to progress, and >58% of drugs go on to fail in phase III. Adaptive clinical trial design has been proposed as a w...

We describe the simple and efficient synthesis of N-substituted isoquinolin-1-one derivatives. Initiating with the coupling of benzoic acids containing vinyl ethers with different amines, followed by rapid intramolecular cyclization under acidic conditions at room temperature, N-substituted isoq...

A Cu-mediated ligand-free arylation of NH-sulfoximines and sulfonamides by arylhydrazine hydrochlorides was herein demonstrated. The oxidative transformation provided an easy access towards N-aryl sulfoximines and sulfonamides in high yields (up to 93% yields) with broad functional groups tolera...

ObjectiveInvasive microorganisms and free radicals are responsible for the delayed healing of various infections. It is necessary to discovery of novel molecules that are effective against invasive microorganisms and inhibit free radicals. Therefore, a series of metal complexes of 2-amino-4-subs...

The crystal structure and spectroscopic properties of (3aR,6S,7aR)-7a-bromo-6-methyl-2-[(4-methylphenyl)sulfonyl]-1,2,3,6,7,7a-hexahydro-3a,6-epoxyisoindole were determined by X-ray diffraction, IR and 13CNMR and 1H NMR spectroscopy techniques. We investigate molecular and crystal structure of t...

1-Heteroaryl-2-aryl-1H-benzimidazole derivatives were synthesized as inhibitors of c-Jun N-terminal kinases, JNK3. Their activities were evaluated through measurement of Kd using SPR, JNK3 kinase assay, and cell-viability of human neuroblastoma cells. Most tested compounds showed high affinity (...

Considerable insights into the oxidoreduction activity of the Xanthomonas campestris bacterioferritin comigratory protein (XcBCP) have been obtained from trapped intermediate/ligand complex structures determined by X-ray crystallography. Multiple sequence alignment and enzyme assay indicate that...

Bacterioferritin comigratory protein (BCP) is a monomeric conformer acting as a putative thiol-dependent bacterial peroxidase, however molecular basis of DNA-protection via DNA-binding has not been clearly understood. In this study, we characterized the DNA binding properties of BCP using variou...

The pharmacological actions of ciguatoxin (methanol-soluble extract) have been investigated, and comparisons drawn with the reported effects of crystalline tetrodotoxin. The ciguatoxin displayed a greater toxicity to the crayfish than to the mouse. The toxin caused an extended depression in the ...

Two new ciguatoxin analogs, 2,3-dihydroxyCTX3C and 51-hydroxyCTX3C, were isolated from the moray eel Gymnothorax javanicus. Their structures including relative configurations were elucidated on the basis of 1H-NMR data.

K. Terao, E. Ito, M. Oarada, Y. Ishibashi, A.-M. Legrand and T. Yasumoto. Light and electron microscopic studies of pathologic changes induced in mice by ciguatoxin poisoning. Toxicon29, 633–643, 1991.—Acute poisoning induced by ciguatoxin or ciguatoxin-4c in male ICR mice was examined by ligh...