A fluorinated diamine, 1,3-bis(4-amino-2-trifluoromethylphenoxy)benzene (mBATB), was synthesized through nucleophilic substitution reaction of Resorcinol and 2-chloro-5-nitrobenzotrifluoride by catalytic reduction with H2 gas and Pd/C. The synthesis and properties of a series of soluble fluorina...

3-Tert-butyl-4-hydroxyanisole (BHA), a synthetic antioxidant, is an initiator in the transformation of BALB/3T3 mouse embryo cells, when cells are treated first with the chemical and then with a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate. In the present study, BHA was examined for its ...

The mutagenicity of 3-tert-butyl-4-hydroxyanisole (BHA) and its metabolites was investigated in the reverse mutation assay using S. typhimurium strains and the chromosomal aberration test in vitro using a Chinese hamster fibroblast cell line, CHL. BHA, tert-butylhydroquinone (BHQ), tert-butylqui...

The voltammetric behaviour of the antioxidants 3-tert-butyl-4-hydroxyanisole (BHA) and tert-butylhydroquinone (TBHQ), at a polymer electrode modified with nickel phthalocyanine as electron mediator, is described, and an electroanalytical method for the determination of these antioxidants based o...

The mechanism of action of 2(3)-tert-butyl-4-hydroxyanisole (2-BHA or 3-BHA) on rat forestomach epithelium was studied by examining the metabolites of BHA in the stomach and the covalent binding of BHA to macromolecules in the forestomach epithelium. Male F344 rats 6 weeks old were given a singl...

High-resolution capillary gas chromatography-mass spectrometry with selective ion monitoring and using deuterated 3-tert-butyl-4-hydroxyanisole (BHA) as an internal standard was used to measure BHA in the plasma and urine of human volunteers after oral administration of 30 or 5 mg of the compoun...

2(3)-tert-Butyl-4-hydroxyanisole (2(3)-BHA) inhibits the action of a broad spectrum of carcinogens, mutagens and tumour promoters. This review discusses available information on four mechanisms by which 2(3)-BHA brings about these inhibitory effects. The first mechanism is induction of increased...

BHA (2(3)-tert-butyl-4-hydroxyanisole) produced inhibition of both culture growth and oxygen consumption, NAD(P) reduction and cytochrome b oxidation, on intact epimastigotes of Trypanosoma cruzi. BHA inhibited respiration and reduced NAD(P) in intact T. cruzi trypomastigotes. Oxidative phosphor...

The urinary and fecal metabolites of orally administered 2-tert-butyl-4-hydroxyanisole (2-BHA) and 3-tert-butyl-4-hydroxyanisole (3-BHA) in rats were identified. Samples of 2-day pooled urine and feces of rats given a single intragastric dose of 1 g/kg wt of tert[butyl-14C]3-BHA (∗Bu-3-BHA). ter...

The FT-IR and FT-Raman spectra of 3-tert-butyl-4-hydroxyanisole (TBHA) molecule have been recorded in the region 4000–400 cm−1 and 3500–100 cm−1, respectively. Optimized geometrical structure, harmonic vibrational frequencies has been computed by B3LYP level using 6-31G (d, p) and 6-311 + G (d...

A normal-phase high performance liquid chromatography method for the simultaneous determination of tert-butylhydroquinone, tert-butylquinone, butylated hydroxytoluene, 2-tert-butyl-4-hydroxyanisole, 3-tert-butyl-4-hydroxyanisole, α-tocopherol, γ-tocopherol, and δ-tocopherol in edible oils was...

Among the commercial ethylenediamine-N,N′-bis(2-hydroxy)phenylacetic acid/iron(III) derivatives, ethylenediamine-N,N′-bis(2-hydroxy-5-sulphophenylacetic) acid/iron(III) (EDDHSA/Fe) represents one of the promising chelates for the treatment of chlorotic plants. Industrial synthesis of EDDHSA/Fe...

GLC with electron-capture detection was applied to the assay of the carbonic anhydrase inhibitor dichlorphenamide and demonstrated a sensitivity of 10 ng in 0.5 ml of rabbit serum or whole aqueous humor (≃ 0.25 ml) from one rabbit eye. After extraction of the drug and internal standard (monochlo...

A tertiary amine derivative, 2-(2-aminoethyl)-1-methylpyrrolidine (AEMP) was successfully developed as electrochemiluminescence (ECL) probe within microfluidic chip using ECL detection in this paper. The system was characterized by the interaction between biotin and avidin. In principle, tertiar...

1-Methylpyrrolidine-2-acetic acid and related compounds were studied as precursors in the biosynthesis of the tropane alkaloids in Erythroxylum coca and Datura innoxia. (R,S)-[1′,2-13C2,2-14C,15N]-1-Methylpyrolidien-2-accetic acid, (R,S)-[1′,2′-13C2,1′-14C]-1-methylpyrrolidine-2-acetic acid,...

N,N-Bistrimethylsilylimidazolidone-2 is significantly more nucleophilic than imidazolidone itself and undergoes polycondensations with dicarboxylic-acid dichlorides in bulk. The resulting poly(N -acylimidazolidone)s are semicrystalline materials, soluble in acidic solvents. Cocondensation with s...

The results of a single-crystal X-ray diffraction study of the 1:2 adduct between dichlorodimethyltin(IV) and 2-imidazolidone are reported, together with some preliminary IR data. The complex is hexacoordinate and with a distorted cis-octahedral geometry.

As a part of the investigation of precipitants with selectivity to U(VI) in nitric acid media, a preliminary study on the precipitation ability of 1,3-dimethyl-2-imidazolidone (DMI) to U(IV), a simulant of Pu(IV), was performed. DMI is a ring compound like N-n-butyl-2-pyrrolidone (NBP) which is ...

Cyclopentanone is a promising building block in the conversion of biomass to fuels. It can be readily obtained from furanics derived from biomass and can be converted to intermediate products in the molecular weight range compatible with fuels via CC bond forming reactions. Among them, aldol con...

Hydrogenative ring-rearrangement reaction of biomass-derived furanic aldehydes to cyclopentanone compounds catalyzed by metal/support bifunctional catalysts suffers a low selectivity of target product and serious carbon loss because of the Brønsted acid catalysis. Herein, a series of pure Lewis ...