This study was performed to compare the exposure effects of N-methyl-N-nitrosourea (MNU), a cytocidal agent of proliferating cells, on rat hippocampal neurogenesis between developmental and postpubertal periods. Developmental exposure through maternal drinking water from gestational day 6 to day...

ObjectiveWe ex vivo cultured primary tumor cells from N-methyl-N-nitrosourea (MNU)-induced bladder tumors in rats and established an immortalized cell line from them.

Aim and main methodThe medicinal properties of fermented papaya preparation (FPP) derived from Carica papaya fruit was investigated in order to determine its ability to modulate the progression of N-methyl-N-nitrosourea induced hepatocellular carcinoma in Balb/c mice.

N-methyl-N-nitrosourea (MNU) possesses peripheral nervous system carcinogenic activity in rats and induces benign and malignant schwannomas in systemic organs. In this retrospective study, we compared the characteristics of various immunohistochemical markers in MNU-induced schwannomas in male C...

BackgroundIn the East Asia, the genus Acer (Aceraceae) is a herbal medicine that is used to treat various diseases, including hemostasis, hepatic disorders, traumatic bleeding and poor eyesight. However, the effects of Acer palmatum thumb. on retinal degeneration are unknown.

Nitrosourea plays an important role in the treatment of cancer. N-ethyl-N-nitrosourea, also known as ENU, (chemical formula C3H7N3O2), is a highly potent mutagen. The chemical is an alkylating agent and acts by transferring the ethyl group of ENU to nucleobases (usually thymine) in nucleic acids...

Ethnopharmacological relevanceCalliandra portoricensis (CP) is a herb widely used in Nigeria for the treatment of breast engorgement. However, the scientific evidence of this use and its mechanisms of action is not clearly understood.

Silane coupling agents have been widely used for immobilizing proteins onto inorganic surfaces. However, the immobilization method using silane coupling agents requires several treatment steps, and its application is limited to only surfaces containing hydroxyl groups. The aim of this study was ...

Many nitrosamines are potent mutagens. The rate-limiting step in their in vitro metabolism to mutagens is usually a single enzymatic reaction catalyzed by one or more of the many cytochrome P-450-dependent mixed-function oxidases present in the microsomal cell fraction. Current evidence indicate...

The impact of topical antimicrobial agents on improving the survival of patients with major thermal injuries is significant. However, the effects of these agents on cells responsible for wound healing has only recently received attention. Fresh human basal keratinocytes were grown in serum-free ...

Mafenide acetate (Sulfamylon) is an antibacterial agent used to prevent and treat burn wound sepsis. No LC method is currently available for the analysis of this drug. A simple LC method was developed and validated for the analysis of sulfamylon. The chromatographic separation was achieved on a ...

Infrequently reported, serious allergic reactions to topical antimicrobial agents used in the treatment of burn injuries are a potential source of confusion. To avoid misdirected therapy, an understanding of the manifestations of such reactions is important. Two recent cases of serious allergic ...

Mafenide is a short acting, broad-spectrum, topical …

Publisher SummaryThis chapter discusses the synthesis, methods of analysis, and physical properties of mafenide acetate. Mafenide is a synthetic anti-infective agent that is closely related to sulfonamides in its chemical composition; it differs structurally from sulfonamides in that it contains...

ObjectiveTo determine if patients receiving topical amphotericin B in combination with 5% mafenide acetate solution will acquire systemically detectable levels of amphotericin B.

The auricle is a frequently injured part of the head and neck during thermal injury leading to ear deformity. The burned ear represents one of the most difficult problems for reconstructive surgeons. Mafenide acetate is a topical agent used routinely for these patients, but it has some disadvant...

ObjectiveFungal infections remain a major cause of mortality in the burned population. Mafenide acetate/amphotericin B solution (SMAT) has been used topically for prophylaxis and treatment of these infections. Current manufacturer guidelines only guarantee the stability of mafenide solution and ...

Wound healing is an important issue in the modern world. In this research, wound healing properties of silver nanoparticles embedded in electrospun nanofibers containing polyvinylalcohol (PVA), polyvinylpyrrolidone (PVP), pectin (PEC) and Mafenide acetate (MF) was studied. Reduction of Ag+ ions ...

KB cells growing exponentially in suspension were infected with type 2 adenovirus at high input multiplicities. An increase in intracellular virus was first detected at 14 hours after infection and reached levels of 4000–10,000 PFU per cell at 36–48 hours after infection. Uninfected cells mult...

It has been possible to obtain wide-angle X-ray diffraction photographs of dilute solutions of the acid form of polyriboadenylic acid in the form of sharp powder diagrams. The spacings so measured indicate a marked degree of similarity between the structure of the polymer in solution and in the ...