A new series of chiral dicationic ionic liquids (DILs) were successfully synthesized and characterized by IR and NMR. The density of the whole family of ILs was measured and related physical properties including thermal expansion coefficient, molecular volume, standard molar entropy, and crystal...

Aqueous two-phase systems (ATPS) based on tropine type chiral ionic liquids and inorganic salt solution were designed and prepared for the enantiomeric separation of racemic phenylalanine. The phase behavior of IL-based ATPS was comprehensive investigated, and phase equilibrium data were correla...

A prodrug, tropine must undergo esterification before it displays anticholinergic activity, with both tropine base and tropic acid being devoid of such activity. The antimuscarinic agents …

A novel aqueous two-phase systems (ATPS) composed of a small molecule organic compound tropine and an organic or inorganic salt aqueous solution has been developed for the first time. The phase behavior of tropine-salt ATPS was systemically investigated and the phase equilibrium data were measur...

In this study, a series of new ionic liquids (ILs) with tropine as cationic nucleus and hexafluorophosphate as anion were synthesized. As two types of functional groups, aliphatic chains and benzyl with different substituents have been linked on the tropine nucleus in order to modulate the physi...

Emulsion liquid membrane (ELM) coupled with tropine-based ionic liquid was prepared and successfully adopted for the extraction and quantitative analysis of tropane alkaloids (TA) in Radix physochlainae. Effects of formation conditions of ELM were explored and then optimized; the ideal oil-water...

Controlled release formulations have been proven to have potential in overcoming the drawbacks of conventional plant growth regulators. Novel controlled-release formulation of β-naphthoxyacetic acid (BNOA) intercalated MgAl-layered double hydroxides (LDHs) was prepared by co-precipitation metho...

Two organic cocrystals namely, 1,10-phenanthroline-5,6-dione:2-naphthoxyacetic acid [(phendione)(2-naa)] (1) and 1,10-phenanthroline-5,6-dione:2-formylphenoxyacetic acid [(phendione)(2-fpaa)] (2) were synthesized and studied by single crystal XRD, FT-IR, NMR, thermogravimetric, and powder X-ray ...

We describe two luminescence methods based on a flow-through optical sensor. A fluorescence and a phosphorescence optosensors have been developed and compared. Both techniques are fast (response time of 150 and 90 s, respectively) and simple. The fluorescence optosensor is based on the on-line i...

Caffeine:1-naphthoxyacetic acid [(caf)(1-naa)] and caffeine:2-naphthoxyacetic acid [(caf)(2-naa)] cocrystals have been synthesized and single crystals were grown by slow evaporation technique. The structures of the grown crystals were elucidated using single crystal X-ray diffraction analysis. B...

A simple, rapid, sensitive and selective method for simultaneously determining 2-naphthoxyacetic acid (BNOA) and Indole-3-Acetic Acid (IAA) in mixtures has been developed using derivation synchronous fluorescence spectroscopy based on their synchronous fluorescence. The synchronous fluorescence ...

Mescaline, 3,4-dimethoxyphenethylamine (DMPEA) or 2,5-dimethoxy-4-methylamphetamine (DOM) was administered to male Sprague-Dawley rats, alone or in combination with para-chlorophenylalanine (PCPA), an inhibitor of serotonin (5-HT) synthesis, or methysergide, a 5-HT receptor blocker. All three co...

α-14C-Dimethoxyphenethylamine hydrochloride was administered to rats, i.p., and the metabolites were isolated and identified from the 0–2.5 hr urine. The following compounds were positively identified (percentages of urinary 14C are given in parentheses): dimethoxyphenylacetic acid (77), uncha...

The pineal hydroxyindole-O-methyl transferase (HIOMT) catalysed formation of N-acetyl-3,4-dimethoxyphenethylamine (NADMPEA) from both N-acetyl-4-hydroxy-3-methoxyphenethylamine and N-acetyl-3-hydroxy-4-methoxyphenethylamine have been demonstrated in vitro. Dimethylation was not achieved. The for...

3,4-dimethoxyphenethylamine (3,4-DMPEA), a product which was found in the urine of schizophrenic patients, was labelled with 11C from hydrogen cyanide as a precursor. The best conditions were selected, this synthesis was carried out in 45 min with a radiochemical yield of 40%. In order to study ...

Procedures for the separation and quantitative determination of 3,4-dimethoxyphenethylamine as the isothiocyanate derivative are given and the thin-layer chromatographic properties of 3,4-dimethoxyphenethylamine isothiocyanate are described. The sensitivity of this method for qualitative identif...

Antibodies to β-3,4-dimethoxyphenethylamine (DMPEA) were produced by immunizing rabbits with conjugates of N-succinyl-DMPEA coupled to poly l-lysine. N-(3′,4′-dimethoxyphenethyl)-4-hydroxyphenylacetamide was synthesized, iodinated to high specific activity, and used to develop a sensitive and...

N-acetyl-β-hydroxy-3,4-dimethoxyphenethylamine was found in the urine of rats after intraperitoneal administration of either 3,4-dimethoxyphenethylamine or N-acetyl-3,4-dimethoxyphenethylamine. Identification was made from Chromatographic, cocrystallization and mass spectral data. The monoamine...

Proton chemical shifts of the following substituted ortho-dimethoxyphenethylamine derivatives: N-2-(2-nitro-4,5-dimethoxyphenyl)ethylphthalimide (1); N-2-(2-nitro-4,5-dimethoxyphenyl)ethylmaleimide (2); 2-nitro-4,5-dimethoxyphenylethylamine (3); N-2-(2-bromo-4,5-dimethoxyphenyl)ethylphthalimide ...

The cactus alkaloid 3,4-dimethoxyphenethylamine and its naturally occurring Al-methylated homologs inhibited the deamination of tyramine and tryptamine by rat brain monoamine oxidase. In contrast, the β-hydroxylated derivatives of this series failed to inhibit the action of monoamine oxidase on...