Electrochemiluminescence (ECL) materials using redox reactions are attracting attention owing to their remarkable advantages, such as simple structure and use of electrodes without work function limitations. In addition, ECL materials are strong in moisture and air atmosphere and independent of ...

Platelet-derived growth factor-BB (PGDF-BB) loaded gelatin microspheres with an average size of about 2 μm was incorporated into chitosan/silk fibroin/glycerophosphate (GP) solutions to prepare composites. The formulated composite solutions were able to form into hydrogels in a temperature rang...

PurposeHyperglycemia is the high risk factor of vascular remodeling induced by angioplasty, and neointimal hyperplasia is strongly implicated in the pathogenesis of vascular remodeling caused by carotid artery balloon injury. Studies have shown that MicroRNA 24 (miR-24) plays an important role i...

In an effort to improve the regenerative nature of corneal repair, this study reports the use of an in vitro human corneal fibroblasts (HCFs) wound model after treatment with three of the main growth factors (GFs) involved in corneal healing: transforming growth factor beta 1 (TGFβ1), platelet-...

SummaryIsoperoxidases can be detected by Fast Blue BB (FBBB: 4′amino-2′,5′-dimethoxybenzanilide) in the presence of hydrogen peroxide at small quantity. It is not possible, however, to use FBBB, as proposed by other investigators to test IAA-oxidase isoenzymes, if hydrogen peroxide is present...

Aptamer-silver decahedral nanoparticles (Ag10NPs-aptamer) based detection was developed for protein. Ag10NPs were synthesized by photochemical method. The advantage of Ag10NPs was its tolerance of NaCl which facilitates the functionalization of silver nanoparticles with all kinds of ssDNA. Attac...

Accurate, fast and sensitive detection of disease-specific protein biomarkers, especially in blood, urine, or other bodily fluids, is an important approach to achieve early disease diagnosis. Platelet-derived growth factor-BB (PDGF-BB), a widely used biomarker, is involved in a substantial numbe...

A fluorescence aptasensor has been designed for sensitive and recyclable detection and extraction of platelet-derived growth factor BB (PDGF-BB) based on nanogel, Thioflavin T (ThT), hairpin DNA containing PDGF-BB aptamer (0.56–2.98 μM), G-quadruplex and its partially complementary strand, and...

The ionization constants of acetarsone (pK1 = 3.73, pK2 = 7.9, pK3 = 9.3) and arsthinol (9.5 ± 0.1) have been determined potentiometrically in aqueous solution and the UV spectra of the individual conjugate species have been deduced. Assignment of the second ionization step of acetarsone to the...

In this paper, we examined arsthinol–cyclodextrin complexes, which display an anticancer activity. The association constants were 17,502 ± 522 M−1 for hydroxypropyl-β-cyclodextrin and 12,038 ± 10,168 M−1 for randomized methylated β-cyclodextrin. 1H NMR experiments in solution also confirmed...

Melarsoprol and arsthinol have been shown to be effective on various leukaemia cell lines. Nevertheless, the tissue distribution of these compounds remains a key point since the bone marrow is considered as the site of action and the central nervous system as the site of the main toxicity. In th...

The N-alkylation of 2-(N-arylamino)ethyl trimethylammonium salts with allyl chloride, benzyl chloride, epichlorohydrin, ethylene chlorohydrin and acrylonitrile was studied and the preparation of 2-(N-allyl-, -benzyl-, -2-hydroxyethyl-, 3-chloro-2-hydroxypropyl-and 2-cyanoethyl-N-arylamino)-ethyl...

Alkylating agents occur in the environment and are formed endogenously. Tobacco smoke contains a variety of alkylating agents or precursors including, among others, N-nitrosodimethylamine (NDMA), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), acrylonitrile and ethylene oxide. We developed...

Sphingolipid derivatives cause diverse effects towards the regulation of intracellular free Ca2+ concentrations ([Ca2+]i) in a multitude of nonexcitable cells. In the present investigation, the effect of C-8 ceramide-1-(2-cyanoethyl) phosphate (C1CP) on store-operated Ca2+ (SOC) entry was invest...

2-Substituted-2H-1,2,3-triazolo-nucleosides with 3-phosphonopropyl, 2-hydroxyethyl, 2-cyanoethyl, carbamoylmethyl, or 1-deoxy-2,5-anhydro-d-mannitol-1-yl on the triazole N-2 nitrogen atom were obtained via the DBU-promoted N-alkylation of 3-(pivaloyloxymethyl)-1-[(NH-1,2,3-triazol-4-yl)methyl]th...

The adsorption behaviors of 2,2′-biquinoline (BiQu) and 8-hydroxyquinoline (8HQu) on gold and silver nanoparticle surfaces have been investigated by means of surface-enhanced Raman scattering (SERS) with the detailed vibrational assignment. The aromatic ring of BiQu and 8HQu appeared to assume ...

The fac-[Re(CO)3(2,2′-biquinoline)Cl] complex has been obtained in reaction of Re(CO)5Cl with 2,2′-biquinoline. The compound has been studied by IR, UV–Vis spectroscopy and X-ray crystallography. The molecular orbital diagram of the tricarbonyl has been calculated with the density functional ...

The molecular structure, vibrational frequencies and the corresponding vibrational assignment of Zn(biq)X2 (X = Cl and Br; biq = 2,2′-biquinoline) have been studied by employing the hybrid density functional theory (B3LYP) method and the complete basis set (DFT) method together with the 6-31G(d...

A new ruthenium complex series of type Ru(NBD)Cl2L (with L = 2,2′-biquinoline derivative) was prepared. Their spectroscopic properties were analysed by RMN 1H, UV–Vis and Infrared and their electrochemical potentials were obtained by cyclic voltammetry technique. The structure for a complex of...

2,2′-biquinoline-4,4′-dicarboxylic acid (BQCOOH) exhibits interesting photoluminescence and electroluminescence properties, which have motivated the development of BQCOOH films. Electrophoretic deposition method (EPD) has been developed for anodic deposition of BQCOOH. The film microstructure ...