Hemolytic blood disorders such as hemoglobinopathies are one of the most widespread diseases in our country. This paper reports non equilibrium thermodynamic analysis of adult normal hemoglobin subjected to variable frequency of electric fields in the range 0.1–100 MHz, comparing with homozygou...

Blood transfusions in the operating room are associated with increased morbidity and mortality as well as increased cost. The technology exists for continuous noninvasive hemoglobin monitoring (SpHb), which could allow for the rapid diagnosis and treatment of acute blood loss anemia secondary to...

After differential screening of a cDNA library corresponding to genes expressed during the early stages of somatic embryogenesis in leaf tissue from the Cichorium hybrid ‘474’ (C. intybus L., var. sativum×C. endivia L., var. latifolia) a nonsymbiotic hemoglobin cDNA was obtained. Studies of t...

Screening for sickle cell disease retinopathy in the north of FranceT.H.C. Tran, A. Mekinian, M. Godinaud, C. Rose

RésuméLe dosage de l'hémoglobine glyquée (HbA1c) s'est imposé comme le gold standard des examens biologiques, indispensable à une prise en charge optimale du patient diabétique. Dans ce cadre, un effort de standardisation a été initié par les principales sociétés savantes (...

IntroductionA growing body of evidence suggests that long-term exposure to air pollutants like nitrogen oxides (NOx) and particulate matter (PM) is associated with the prevalence and incidence of type 2 diabetes mellitus. Serum glucose and glycosylated hemoglobin (HbA1c) levels are biomarkers of...

Hb Calais [β 76 (E20) Ala → Pro] is a new human hemoglobin variant displaying a decreased oxygen affinity. The only electrophoretical difference with Hb A was a slight more acidic isoelectric point. A 2-fold decrease in the oxygen affinity was found by equilibrium measurements performed in a s...

Oxyhemoglobin dissociation curves (ODC) were performed on blood from diabetic and nondiabetic subjects with and without hypertriglyceridemia. P50 at in vivo pH was slightly lower than normal in normolipemic diabetics (25.7 versus 26.6 mmHg, p

Haemoglobin Aalborg (Gly74 (E18)β → Arg) has a reduced oxygen affinity, in both the absence and the presence of organic phosphates: it has a raised affinity for organic phosphates, and it is moderately unstable. By contrast, haemoglobin Shepherds Bush (Gly74 (E18)β → Asp) has an increased ox...

Monoamine oxidase B was previously shown to be inactivated by cis- (3) and trans-5-(aminomethyl)-3-(4-methoxyphenyl)dihydrofuran-2(3H)-one hydrochloride (4) in a time-dependent manner (Ding, Z.; Silverman, R. B. J. Med. Chem. 1992, 35, 885) and to catalyze its oxidative decarboxylation (Silverma...

Catalytic activity and oxidative stability of a series of Mn-porphyrins (Mn-pors) with pyridyl (2-, 3- or 4-), 4-sulfonatophenyl, 3-sulfonato-4-methoxyphenyl, phenyl and 4-methoxyphenyl in oxidation of olefins with tetra-n-butylammonium periodate has been investigated in a comparative study. Whi...

A series of multiple aromatic ether-linked phthalonitrile resins containing an aromatic ether phosphine oxide group in the backbone have been synthesized and characterized. The oligomeric phthalonitrile monomers were prepared from the reaction of an excess amount of either bisphenol A or resorci...

Six novel polyamides, incorporating triarylphosphine oxide groups and aliphatic bridging units, have been prepared. Of these, three were synthesised by a direct melt condensation reaction of bis(4-carboxyphenyl)phenylphosphine oxide (p-BCPPO) with a series of aliphatic diamines. A phosphorylatio...

Three phenylphosphine oxide (PPO) containing trifluorovinyl aryl ether monomers were synthesized and polymerized via thermal cyclodimerization affording perfluorocyclobutyl (PFCB) polymers containing PPO pendent groups. The new polymers exhibited moderate to high glass transition temperatures (T...

This paper reports the synthesis and characterization of a series of new semi-fluorinated sulfonated copolyimides (co-SPI) using a new trifluoromethyl and phosphine oxide containing diamine monomer, namely bis[4-(4′-aminophenoxy)-3-trifluoromethyl phenyl] phenylphosphine oxide (DFPPO). The copo...

A series of aromatic polyimides (PI-IIa–d) containing lateral phenylphosphine oxide (PPO) and trifluoromethyl (–CF3) moiety were prepared from an aromatic diamine, 2,5-bis[(4-amino-2-trifluoromethylphenoxy)phenyl]diphenyl-phosphine oxide (BATFDPO) and various aromatic dianhydrides via a two-st...

In this study, a novel hybrid copolyimide was synthesized from copolyamic acid solutions (PAAs) obtained by the reaction between bis(3-aminophenoxy-4-phenyl)phenylphosphine oxide (m-BAPPO), 3,3′-diaminodiphenyl sulfone (DDS) and 3,3′,4,4′-benzophenone tetracarboxylic dianhydride (BTDA), follo...

A novel meta-substituted aromatic diamine, [3,5-bis(3-aminophenoxy)phenyl]diphenylphosphine oxide (m-BADPO) was synthesized by the Williamson reaction of 3,5-difluorophenyldiphenylphosphine oxide (DFPPO) and meta-aminophenol. The diamine was then polymerized with several commercially available a...

A novel fluorinated aromatic diamine, bis[4-(4′-aminophenoxy)phenyl]-3,5-bis(trifluoromethyl)phenyl phosphine oxide, was synthesized. A series of new fluorinated polyimides containing phosphine oxide was prepared from the novel diamine with various commercially available aromatic dianhydrides. ...

Infection triggers the release of pro-inflammatory cytokines (TNF-alpha and IL-6). Over-production, however, cause tissue injury seen in severe asthma. The ability of enaminone E121 to reduce pro-inflammatory cytokines in our laboratory encouraged further examination of its structural scaffold. ...