Frankincense can be obtained from various species of the genus Boswellia and, interestingly, it has been employed for medicinal, religious, and sacrificial purposes for over 5000 years. There are a number of triterpenes, such as ursanes and oleanane-type triterpenes, which are the major natural ...

Medium-chain fatty acid (MCFA) ethyl esters, as yeast secondary metabolites, significantly contribute to the fruity aroma of foods and beverages. To improve the MCFA ethyl ester content of wine, mixed fermentations with Hanseniaspora uvarum Yun268 and Saccharomyces cerevisiae were performed. Fin...

Biodiesels, composed of saturated fatty acid alkyl esters (FAAE), have relatively high cloud points (CP), which limit their commercial application. However, fatty acid ethyl esters (FAEE) have potentially advantageous properties, including those related to cold flow, compared to their methyl ana...

According to the Regulation (EU) 2016/2095, extra virgin olive oils (EVOO) must contain a maximum of 35 mg kg−1 of fatty acid ethyl esters (FAEE). The official method for FAEE quantification is time-consuming and requires the use of a large amount of toxic solvents. Thus, the aim of this work wa...

BackgroundThe Reduction of Cardiovascular Events with Icosapent Ethyl–Intervention Trial (REDUCE-IT) study demonstrated that 4 g/d of eicosapentaenoic acid (EPA) ethyl esters (icosapent ethyl [IPE]) reduced risk for major cardiovascular events by 25% in statin-treated patients with residual hyp...

New poly(arylene ether)s with pendent trifluoromethyl groups were synthesized from 2,2′-bis(trifluoromethyl)-4,4′-dinitro-1,1′-biphenyl with several bisphenols. The nitro leaving group activated by the trifluoromethyl group at meta position was quantitatively displaced with phenolate ions, re...

A two-step process for the synthesis of aryl and heteroaryl trifluoromethyl ketones from the corresponding aldehydes is described. Trifluoromethyl alcohols were prepared from aryl and heteroaryl aldehydes in excellent yields using catalytic amount of K2CO3. The trifluoromethyl alcohols were then...

A novel and efficient method for the synthesis of gem-difluoroallylboronates via copper-catalyzed defluorinative borylation of α-trifluoromethyl alkenes with B2pin2 using Xantphos as ligand and NaOtBu as base was developed.

A small library of fluoroethoxy-1,4-diphenethyl piperidine and fluoroethoxy-1,4-diphenethyl piperazine derivatives were designed, synthesized and evaluated for their ability to inhibit [3H]dopamine (DA) uptake at the vesicular monoamine transporter-2 (VMAT2) and dopamine transporter (DAT), [3H]s...

The 5-HT1AR partial agonist PET radiotracer, [11C]CUMI-101, has advantages over an antagonist radiotracer as it binds preferentially to the high affinity state of the receptor and thereby provides more functionally meaningful information. The major drawback of C-11 tracers is the lack of cyclotr...

IntroductionEstablished radiotracers for positron emission tomography (PET) myocardial perfusion study are commonly labeled with short-lived radio-isotopes that limit their widespread clinical use. Thus, we synthesized (2-(2-[18F]fluoroethoxy)ethyl)tris(4-methoxyphenyl)phosphonium salt ([18F]FET...

N-(2-Benzofuranylmethyl)-N′-[4-(2-fluoroethoxy)benzyl]piperazine (6, σ1 Ki = 2.6 nM) was radiolabeled with fluorine-18 to provide a potential σ1 receptor radioligand for use in positron emission tomography (PET). Radiofluorination of the appropriate tosylate precursor furnished [18F]6 with a ...

[18F]-labeled molecular probe for the detection of myocardial perfusion deficit is driving particular interest due to its high clinical applicability. Thus, we synthesized (2-(2-[18F]fluoroethoxy)ethyl)triphenylphosphonium salt ([18F]3) that specifically accumulates in myocardium according to mi...

A convenient remote controlled synthesis of a new tryptophan analog, l-5-(2-[18F] fluoroethoxy)-tryptophan (5-18FEHTP) was described. The radiochemical yield within 65 min was about 12–16% without decay correction, the radiochemical purity was over 98%, and 5-18FEHTP dissolved in saline was sta...

Translocator Protein (18 kDa, TSPO) is regarded as a useful biomarker for neuroinflammation imaging. TSPO PET imaging could be used to understand the role of neuroinflammation in brain diseases and as a tool for evaluating novel therapeutic effects. As a promising TSPO probe, [18F]DPA-714 is hig...

Given the ever-present demand for improved PET radiotracer in oncology imaging, we have synthesized 2-(3,4-dimethoxyphenyl)-6-(2-[18F]fluoroethoxy)benzothiazole ([18F]FEDBT), a fluorine-18-containing fluoroethylated benzothiazole to explore its utility as a PET imaging tracer. [18F]FEDBT was pre...

A series of lobelane and GZ-793A analogues that incorporate aromatic 4-hydroxy and 4-(2-fluoroethoxy) substituents were synthesized and evaluated for inhibition of [3H]dopamine (DA) uptake at the vesicular monoamine transporter-2 (VMAT2) and the dopamine transporter (DAT), and [3H]serotonin upta...

In continuation of our study on the 2-phenylquinoxaline scaffold as potential β-amyloid imaging probes, two [18F]fluoro-pegylated 2-phenylquinoxaline derivatives, 2-(4-(2-[18F]fluoroethoxy)phenyl)-N-methylquinoxalin-6-amine ([18F]4a) and 2-(4-(2-(2-(2-[18F]fluoroethoxy)ethoxy)ethoxy)phenyl)-N-m...

18F-labeled non-sulfonylurea hypoglycemic agent (S)-2-(2-[18F]fluoroethoxy)-4-((3-methyl-1-(2-piperidin-1-yl-phenyl)-butylcarbamoyl)-methyl)-benzoic acid ([18F]repaglinide), a derivative of the sulfonylurea-receptor (SUR) ligand repaglinide, was synthesized as a potential tracer for the non-inva...

In this study, the synthesis of phthalonitrile derivatives bearing fluoro-functionalized groups and their peripherally-tetra substituted zinc phthalocyanine complexes were reported. The phthalonitrile derivatives 2a–5a were prepared by nucleophilic substitution of 4-nitrophthalonitrile with 2-[...