IaaS cloud providers typically leverage virtualization technology (VT) to multiplex underlying physical resources among virtual machines (VMs), thereby enhancing the utilization of physical resources. However, the contention on shared physical resources brought about by VT is one of the main cau...

In this work we propose an improvement to the Wang–Landau (WL) method that allows an economy in CPU time of about 60% leading to the same results with the same accuracy. We used the 2D Ising model to show that one can initiate all WL simulations using the outputs of an advanced WL level from a ...

Hybrid multi-core processors are poised to dominate the landscape of next generation computing. By integrating several types of cores on a single chip, designers are anticipating sustained performance growth while depending less on raw circuit speed and decreasing power requirements per unit of ...

In a virtualized system, the virtual machine (VM) scheduler plays a key role to the performance promotion of the virtual machine monitor (VMM), a.k.a. hypervisor. The scheduler is responsible for assigning adequate system resources to each VM according to the demands of the VM tenants, which is ...

An experiment system for CPU cooling based on nanofluids is set up. The flow and heat transfer characteristics of TiO2-water nanofluids in CPU heat sink are experimentally investigated. The influences of rectangular groove depths (1 mm, 2 mm) and cylindrical bulge arrangement modes (aligned and ...

The small physical size of electronic equipment, space limitation for installing air-cooling systems and high heat flux produced from a single chip have attracted a great deal of interest in more efficient heat dissipation equipment such as high-performance liquid cooling systems and mini-rectan...

In this work, a technique for improving the convergence properties (speed and reliability) of a non monotonic Basin Hopping algorithm is presented. This modification of Basin Hopping happens to be highly parallelizable and therefore the parallel implementation is shown both for multi-CPU and GPU...

Software power estimation of CPUs is a central concern for energy efficiency and resource management in data centers. Over the last few years, a dozen of ad hoc power models have been proposed to cope with the wide diversity and the growing complexity of modern CPU architectures. However, most o...

An experiment set for researching the flow and heat transfer characteristics of nanofluids flowing through CPU is established and validated. The influences of groove depths (1 mm, 2 mm, 3 mm) and arrangement modes (aligned and staggered arrangements) on thermo-hydraulic performances of CPU coole...

Graphical Processing Unit provides massive parallelism due to the presence of hundreds of cores. Usage of GPUs for general purpose computation (GPGPU) has resulted in execution speedup and energy efficiency. In addition, the modern CPUs also possess multiple cores, with enormous computational po...

Efficient processing of graph applications on heterogeneous CPU–GPU systems require effectively harnessing the combined power of both the CPU and GPU devices. This paper presents HyPar, a divide-and-conquer model for processing graph applications on hybrid CPU–GPU systems. Our strategy partiti...

Although tremendous strides have been made in face detection, one of the remaining open issues is to achieve CPU real-time speed as well as maintain high performance, since effective models for face detection tend to be computationally prohibitive. To address this issue, we propose a novel face ...

Effects of the 5-hydroxytryptamine (5-HT)1A/1B/2C receptor agonist N-[3-(trifluoromethyl)phenyl] piperazine (TFMPP, 0–3.0 mg/kg s.c.) and the 5-HT2C receptor agonist 8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one (WAY 161503, 0–3.0 mg/kg s.c.) in place conditioning wer...

N′-Cyanoisonicotinamidine derivatives, linked to an arylpiperazine moiety, were prepared to identify highly selective and potent 5-HT1A ligands as potential pharmacological tools in studies of wide spread psychiatric disorders. The combination of structural elements (heterocyclic nucleus, alkyl...

In continuation of our investigation on novel stearoyl-CoA desaturase (SCD) 1 inhibitors, we have already reported on the structural modification of the benzoylpiperidines that led to a series of novel and highly potent spiropiperidine-based SCD1 inhibitors. In this report, we would like to exte...

The discovery and synthesis of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor 1-receptor (IGF-1R) are presented. Installing amine containing side chains at the 4-position of pyridone ring significantly improved the enzyme potency. SAR and biological activi...

A series of novel morpholine, thiomorpholine and N-substituted piperazine coupled 2-(thiophen-2-yl)dihydroquinolines 7a–p was designed and synthesized from 2-acetyl thiophene in six step reaction sequence involving modified Bohlmann-Rahtz and Vilsmeier-Haack-Arnold reactions as key transformati...

Oxidative stress, inflammation and fibrosis can cause irreversible damage on cell structure and function of kidney and are key pathological factors in Diabetic Nephropathy (DN). Therefore, multi-target agents are urgently need for the clinical treatment of DN. Using Pirfenidone as a lead compoun...

The synthesis of 4-isochromanones via Parham-type cyclization with Weinreb amide as the internal electrophilic group, t-BuLi as the lithium reagent was described. The reaction was efficient and could be completed in one minute. The application scope of this new protocol was investigated and the ...

5-(4-Methylpiperidino)methyl-2-thiouracil (1) has been obtained via the Mannich reaction between 2-thiouracil, paraformaldehyde, and a cyclic secondary amine such as 4-methylpiperidine (4-MP) in ethanol. New S,N(1)-di-o-(m- and p-)bromo-(nitro-) benzyl-substituted derivatives have been synthesiz...